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Bedeutung molekular-zytogenetischer Befunde bei Speicheldrüsentumoren am Beispiel des Mukoepidermoidkarzinoms

Standard

Bedeutung molekular-zytogenetischer Befunde bei Speicheldrüsentumoren am Beispiel des Mukoepidermoidkarzinoms. / Röser, K; Jäkel, K T; Bullerdiek, J; Löning, T.

in: PATHOLOGE, Jahrgang 26, Nr. 5, 09.2005, S. 359-66.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Röser, K, Jäkel, KT, Bullerdiek, J & Löning, T 2005, 'Bedeutung molekular-zytogenetischer Befunde bei Speicheldrüsentumoren am Beispiel des Mukoepidermoidkarzinoms', PATHOLOGE, Jg. 26, Nr. 5, S. 359-66. https://doi.org/10.1007/s00292-005-0778-x

APA

Röser, K., Jäkel, K. T., Bullerdiek, J., & Löning, T. (2005). Bedeutung molekular-zytogenetischer Befunde bei Speicheldrüsentumoren am Beispiel des Mukoepidermoidkarzinoms. PATHOLOGE, 26(5), 359-66. https://doi.org/10.1007/s00292-005-0778-x

Vancouver

Röser K, Jäkel KT, Bullerdiek J, Löning T. Bedeutung molekular-zytogenetischer Befunde bei Speicheldrüsentumoren am Beispiel des Mukoepidermoidkarzinoms. PATHOLOGE. 2005 Sep;26(5):359-66. https://doi.org/10.1007/s00292-005-0778-x

Bibtex

@article{b7bb5b24e2d549d9888bb5d27c90aa75,
title = "Bedeutung molekular-zytogenetischer Befunde bei Speicheldr{\"u}sentumoren am Beispiel des Mukoepidermoidkarzinoms",
abstract = "Chromosome translocations in tumors frequently give rise to fusion genes encoding proteins with oncogenic activities. Mucoepidermoid carcinomas (MEC) are characterized by a t(11;19)(q21-22;p13) translocation found in approximately 60% of the tumors. This t(11;19) translocation results in a fusion gene consisting of exon 1 of the MECT 1 gene and exons 2-5 of the MAML 2 gene. As a result of the t(11;19) a fusion protein is generated which, independent of NOTCH-ligands, activates the transcription of the NOTCH target gene HES 1. The altered function of MAML 2 causes a disruption of NOTCH signalling which suggests a novel mechanism of tumorigenesis. Pending the elucidation of the t(11;19) at the molecular level of an apparently identical chromosomal translocation in Warthin's tumor, the identification of the translocation in MEC by FISH- and/or RT-PCR-analyses may become important in diagnosis and might have prognostic relevance. Warthin's tumors are benign salivary gland neoplasms with a distinctive histomorphology and histogenesis completely different from MEC.",
keywords = "Carcinoma, Mucoepidermoid, Chromosome Aberrations, Exons, Humans, Oncogene Proteins, Fusion, Polymerase Chain Reaction, Salivary Gland Neoplasms, Translocation, Genetic, English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "K R{\"o}ser and J{\"a}kel, {K T} and J Bullerdiek and T L{\"o}ning",
year = "2005",
month = sep,
doi = "10.1007/s00292-005-0778-x",
language = "Deutsch",
volume = "26",
pages = "359--66",
journal = "PATHOLOGE",
issn = "0172-8113",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Bedeutung molekular-zytogenetischer Befunde bei Speicheldrüsentumoren am Beispiel des Mukoepidermoidkarzinoms

AU - Röser, K

AU - Jäkel, K T

AU - Bullerdiek, J

AU - Löning, T

PY - 2005/9

Y1 - 2005/9

N2 - Chromosome translocations in tumors frequently give rise to fusion genes encoding proteins with oncogenic activities. Mucoepidermoid carcinomas (MEC) are characterized by a t(11;19)(q21-22;p13) translocation found in approximately 60% of the tumors. This t(11;19) translocation results in a fusion gene consisting of exon 1 of the MECT 1 gene and exons 2-5 of the MAML 2 gene. As a result of the t(11;19) a fusion protein is generated which, independent of NOTCH-ligands, activates the transcription of the NOTCH target gene HES 1. The altered function of MAML 2 causes a disruption of NOTCH signalling which suggests a novel mechanism of tumorigenesis. Pending the elucidation of the t(11;19) at the molecular level of an apparently identical chromosomal translocation in Warthin's tumor, the identification of the translocation in MEC by FISH- and/or RT-PCR-analyses may become important in diagnosis and might have prognostic relevance. Warthin's tumors are benign salivary gland neoplasms with a distinctive histomorphology and histogenesis completely different from MEC.

AB - Chromosome translocations in tumors frequently give rise to fusion genes encoding proteins with oncogenic activities. Mucoepidermoid carcinomas (MEC) are characterized by a t(11;19)(q21-22;p13) translocation found in approximately 60% of the tumors. This t(11;19) translocation results in a fusion gene consisting of exon 1 of the MECT 1 gene and exons 2-5 of the MAML 2 gene. As a result of the t(11;19) a fusion protein is generated which, independent of NOTCH-ligands, activates the transcription of the NOTCH target gene HES 1. The altered function of MAML 2 causes a disruption of NOTCH signalling which suggests a novel mechanism of tumorigenesis. Pending the elucidation of the t(11;19) at the molecular level of an apparently identical chromosomal translocation in Warthin's tumor, the identification of the translocation in MEC by FISH- and/or RT-PCR-analyses may become important in diagnosis and might have prognostic relevance. Warthin's tumors are benign salivary gland neoplasms with a distinctive histomorphology and histogenesis completely different from MEC.

KW - Carcinoma, Mucoepidermoid

KW - Chromosome Aberrations

KW - Exons

KW - Humans

KW - Oncogene Proteins, Fusion

KW - Polymerase Chain Reaction

KW - Salivary Gland Neoplasms

KW - Translocation, Genetic

KW - English Abstract

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1007/s00292-005-0778-x

DO - 10.1007/s00292-005-0778-x

M3 - SCORING: Zeitschriftenaufsatz

C2 - 16075259

VL - 26

SP - 359

EP - 366

JO - PATHOLOGE

JF - PATHOLOGE

SN - 0172-8113

IS - 5

ER -