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Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.

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Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. / McGill, Gaël G; Horstmann, Martin; Widlund, Hans R; Du, Jinyan; Motyckova, Gabriela; Nishimura, Emi K; Lin, Yi-Ling; Ramaswamy, Sridhar; Avery, William; Ding, Han-Fei; Jordan, Siobhán A; Jackson, Ian J; Korsmeyer, Stanley J; Golub, Todd R; Fisher, David E.

in: CELL, Jahrgang 109, Nr. 6, 6, 2002, S. 707-718.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

McGill, GG, Horstmann, M, Widlund, HR, Du, J, Motyckova, G, Nishimura, EK, Lin, Y-L, Ramaswamy, S, Avery, W, Ding, H-F, Jordan, SA, Jackson, IJ, Korsmeyer, SJ, Golub, TR & Fisher, DE 2002, 'Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.', CELL, Jg. 109, Nr. 6, 6, S. 707-718. <http://www.ncbi.nlm.nih.gov/pubmed/12086670?dopt=Citation>

APA

McGill, G. G., Horstmann, M., Widlund, H. R., Du, J., Motyckova, G., Nishimura, E. K., Lin, Y-L., Ramaswamy, S., Avery, W., Ding, H-F., Jordan, S. A., Jackson, I. J., Korsmeyer, S. J., Golub, T. R., & Fisher, D. E. (2002). Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. CELL, 109(6), 707-718. [6]. http://www.ncbi.nlm.nih.gov/pubmed/12086670?dopt=Citation

Vancouver

McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK et al. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. CELL. 2002;109(6):707-718. 6.

Bibtex

@article{a2aaef8d059843b7bc3794afc62f9756,
title = "Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.",
abstract = "Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and which exhibited phenotypic synergy with Mitf in mice. BCL2's regulation by Mitf was verified in melanocytes and melanoma cells and by chromatin immunoprecipitation of the BCL2 promoter. Mitf also regulates BCL2 in osteoclasts, and both Mitf(mi/mi) and Bcl2(-/-) mice exhibit severe osteopetrosis. Disruption of Mitf in melanocytes or melanoma triggered profound apoptosis susceptible to rescue by BCL2 overexpression. Clinically, primary human melanoma expression microarrays revealed tight nearest neighbor linkage for MITF and BCL2. This linkage helps explain the vital roles of both Mitf and Bcl2 in the melanocyte lineage and the well-known treatment resistance of melanoma.",
author = "McGill, {Ga{\"e}l G} and Martin Horstmann and Widlund, {Hans R} and Jinyan Du and Gabriela Motyckova and Nishimura, {Emi K} and Yi-Ling Lin and Sridhar Ramaswamy and William Avery and Han-Fei Ding and Jordan, {Siobh{\'a}n A} and Jackson, {Ian J} and Korsmeyer, {Stanley J} and Golub, {Todd R} and Fisher, {David E}",
year = "2002",
language = "Deutsch",
volume = "109",
pages = "707--718",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.

AU - McGill, Gaël G

AU - Horstmann, Martin

AU - Widlund, Hans R

AU - Du, Jinyan

AU - Motyckova, Gabriela

AU - Nishimura, Emi K

AU - Lin, Yi-Ling

AU - Ramaswamy, Sridhar

AU - Avery, William

AU - Ding, Han-Fei

AU - Jordan, Siobhán A

AU - Jackson, Ian J

AU - Korsmeyer, Stanley J

AU - Golub, Todd R

AU - Fisher, David E

PY - 2002

Y1 - 2002

N2 - Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and which exhibited phenotypic synergy with Mitf in mice. BCL2's regulation by Mitf was verified in melanocytes and melanoma cells and by chromatin immunoprecipitation of the BCL2 promoter. Mitf also regulates BCL2 in osteoclasts, and both Mitf(mi/mi) and Bcl2(-/-) mice exhibit severe osteopetrosis. Disruption of Mitf in melanocytes or melanoma triggered profound apoptosis susceptible to rescue by BCL2 overexpression. Clinically, primary human melanoma expression microarrays revealed tight nearest neighbor linkage for MITF and BCL2. This linkage helps explain the vital roles of both Mitf and Bcl2 in the melanocyte lineage and the well-known treatment resistance of melanoma.

AB - Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and which exhibited phenotypic synergy with Mitf in mice. BCL2's regulation by Mitf was verified in melanocytes and melanoma cells and by chromatin immunoprecipitation of the BCL2 promoter. Mitf also regulates BCL2 in osteoclasts, and both Mitf(mi/mi) and Bcl2(-/-) mice exhibit severe osteopetrosis. Disruption of Mitf in melanocytes or melanoma triggered profound apoptosis susceptible to rescue by BCL2 overexpression. Clinically, primary human melanoma expression microarrays revealed tight nearest neighbor linkage for MITF and BCL2. This linkage helps explain the vital roles of both Mitf and Bcl2 in the melanocyte lineage and the well-known treatment resistance of melanoma.

M3 - SCORING: Zeitschriftenaufsatz

VL - 109

SP - 707

EP - 718

JO - CELL

JF - CELL

SN - 0092-8674

IS - 6

M1 - 6

ER -