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Barriers and more: functions of tight junction proteins in the skin.

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Barriers and more: functions of tight junction proteins in the skin. / Kirschner, Nina; Brandner, Johanna.

in: ANN NY ACAD SCI, Jahrgang 1257, 2012, S. 158-166.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kirschner, N & Brandner, J 2012, 'Barriers and more: functions of tight junction proteins in the skin.', ANN NY ACAD SCI, Jg. 1257, S. 158-166. <http://www.ncbi.nlm.nih.gov/pubmed/22671602?dopt=Citation>

APA

Kirschner, N., & Brandner, J. (2012). Barriers and more: functions of tight junction proteins in the skin. ANN NY ACAD SCI, 1257, 158-166. http://www.ncbi.nlm.nih.gov/pubmed/22671602?dopt=Citation

Vancouver

Kirschner N, Brandner J. Barriers and more: functions of tight junction proteins in the skin. ANN NY ACAD SCI. 2012;1257:158-166.

Bibtex

@article{1186f4fdca9a43e4b5ce297d69135461,
title = "Barriers and more: functions of tight junction proteins in the skin.",
abstract = "Although the existence of tight junction (TJ) structures (or a secondary epidermal barrier) was postulated for a long time, the first description of TJ proteins in the epidermis (occludin, ZO-1, and ZO-2) was only fairly recent. Since then, a wealth of new insights concerning TJs and TJ proteins, including their functional role in the skin, have been gathered. Of special interest is that the epidermis as a multilayered epithelium exhibits a very complex localization pattern of TJ proteins, which results in different compositions of TJ protein complexes in different layers. In this review, we summarize our current knowledge about the role of TJ proteins in the epidermis in barrier function, cell polarity, vesicle trafficking, differentiation, and proliferation. We hypothesize that TJ proteins fulfill TJ structure-dependent and structure-independent functions and that the specific function of a TJ protein may depend on the epidermal layer where it is expressed.",
keywords = "Animals, Humans, Protein Transport, Claudins/physiology, Epidermis/*physiology, Epithelium/physiology, Occludin/physiology, Tight Junction Proteins/*physiology, Tight Junctions/*physiology, Zonula Occludens-1 Protein/physiology, Zonula Occludens-2 Protein/physiology, Animals, Humans, Protein Transport, Claudins/physiology, Epidermis/*physiology, Epithelium/physiology, Occludin/physiology, Tight Junction Proteins/*physiology, Tight Junctions/*physiology, Zonula Occludens-1 Protein/physiology, Zonula Occludens-2 Protein/physiology",
author = "Nina Kirschner and Johanna Brandner",
year = "2012",
language = "English",
volume = "1257",
pages = "158--166",
journal = "ANN NY ACAD SCI",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Barriers and more: functions of tight junction proteins in the skin.

AU - Kirschner, Nina

AU - Brandner, Johanna

PY - 2012

Y1 - 2012

N2 - Although the existence of tight junction (TJ) structures (or a secondary epidermal barrier) was postulated for a long time, the first description of TJ proteins in the epidermis (occludin, ZO-1, and ZO-2) was only fairly recent. Since then, a wealth of new insights concerning TJs and TJ proteins, including their functional role in the skin, have been gathered. Of special interest is that the epidermis as a multilayered epithelium exhibits a very complex localization pattern of TJ proteins, which results in different compositions of TJ protein complexes in different layers. In this review, we summarize our current knowledge about the role of TJ proteins in the epidermis in barrier function, cell polarity, vesicle trafficking, differentiation, and proliferation. We hypothesize that TJ proteins fulfill TJ structure-dependent and structure-independent functions and that the specific function of a TJ protein may depend on the epidermal layer where it is expressed.

AB - Although the existence of tight junction (TJ) structures (or a secondary epidermal barrier) was postulated for a long time, the first description of TJ proteins in the epidermis (occludin, ZO-1, and ZO-2) was only fairly recent. Since then, a wealth of new insights concerning TJs and TJ proteins, including their functional role in the skin, have been gathered. Of special interest is that the epidermis as a multilayered epithelium exhibits a very complex localization pattern of TJ proteins, which results in different compositions of TJ protein complexes in different layers. In this review, we summarize our current knowledge about the role of TJ proteins in the epidermis in barrier function, cell polarity, vesicle trafficking, differentiation, and proliferation. We hypothesize that TJ proteins fulfill TJ structure-dependent and structure-independent functions and that the specific function of a TJ protein may depend on the epidermal layer where it is expressed.

KW - Animals

KW - Humans

KW - Protein Transport

KW - Claudins/physiology

KW - Epidermis/physiology

KW - Epithelium/physiology

KW - Occludin/physiology

KW - Tight Junction Proteins/physiology

KW - Tight Junctions/physiology

KW - Zonula Occludens-1 Protein/physiology

KW - Zonula Occludens-2 Protein/physiology

KW - Animals

KW - Humans

KW - Protein Transport

KW - Claudins/physiology

KW - Epidermis/physiology

KW - Epithelium/physiology

KW - Occludin/physiology

KW - Tight Junction Proteins/physiology

KW - Tight Junctions/physiology

KW - Zonula Occludens-1 Protein/physiology

KW - Zonula Occludens-2 Protein/physiology

M3 - SCORING: Journal article

VL - 1257

SP - 158

EP - 166

JO - ANN NY ACAD SCI

JF - ANN NY ACAD SCI

SN - 0077-8923

ER -