Aymptomatic CMV viremia is associated with increased levels of serum amyloid A in patients with advanced HIV-infection.
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Aymptomatic CMV viremia is associated with increased levels of serum amyloid A in patients with advanced HIV-infection. / Steininger, Christoph; Graninger, W; Zoufaly, Alexander; Zöllner, B; Feucht, Heinz Hubert; Kundi, M; Stahmer, I; Stellbrink, H-J; van Lunzen, Jan.
in: EUR J MED RES, Jahrgang 13, Nr. 6, 6, 2008, S. 304-308.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Aymptomatic CMV viremia is associated with increased levels of serum amyloid A in patients with advanced HIV-infection.
AU - Steininger, Christoph
AU - Graninger, W
AU - Zoufaly, Alexander
AU - Zöllner, B
AU - Feucht, Heinz Hubert
AU - Kundi, M
AU - Stahmer, I
AU - Stellbrink, H-J
AU - van Lunzen, Jan
PY - 2008
Y1 - 2008
N2 - OBJECTIVE: We evaluated assays for the measurement of acute phase protein levels in plasma for their usefulness to identify sensitively an inflammatory response to active cytomegalovirus CMV infection in HIV-infected patients. METHODS: Plasma samples were collected from 28 CMV-seropositive patients with advanced HIV-infection (CD4-cell count 3 mg/L discriminated with 100% sensitivity and 40% specificity between HIV-infected patients with and without active CMV infection. Sensitivity of fibronectin was 100% and specificity 15% at a threshold-value corresponding with the lower limit of normal values as defined by the manufacturer of the assay (>29 mg/dL). Levels of the other acute phase proteins evaluated did not correlate with detection of CMV-DNA in plasma. CONCLUSION: Increased levels of SAA indicate sensitively an inflammatory response to active CMV infection. Use of a CMV-specific virological assay is required to confirm the specificity of a high SAA-level but may be limited to samples with high SAA-levels. Hence, screening for increased levels of SAA in patients with advanced HIV-infection may allow early identification of active CMV infection.
AB - OBJECTIVE: We evaluated assays for the measurement of acute phase protein levels in plasma for their usefulness to identify sensitively an inflammatory response to active cytomegalovirus CMV infection in HIV-infected patients. METHODS: Plasma samples were collected from 28 CMV-seropositive patients with advanced HIV-infection (CD4-cell count 3 mg/L discriminated with 100% sensitivity and 40% specificity between HIV-infected patients with and without active CMV infection. Sensitivity of fibronectin was 100% and specificity 15% at a threshold-value corresponding with the lower limit of normal values as defined by the manufacturer of the assay (>29 mg/dL). Levels of the other acute phase proteins evaluated did not correlate with detection of CMV-DNA in plasma. CONCLUSION: Increased levels of SAA indicate sensitively an inflammatory response to active CMV infection. Use of a CMV-specific virological assay is required to confirm the specificity of a high SAA-level but may be limited to samples with high SAA-levels. Hence, screening for increased levels of SAA in patients with advanced HIV-infection may allow early identification of active CMV infection.
M3 - SCORING: Zeitschriftenaufsatz
VL - 13
SP - 304
EP - 308
JO - EUR J MED RES
JF - EUR J MED RES
SN - 0949-2321
IS - 6
M1 - 6
ER -
