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Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage

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Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage. / Lehnerer, Sophie Mirabell; Scheibe, Franziska ; Buchert, Ralph; Kliesch, Stefan; Meisel, Andreas.

in: BMJ CASE REP, Jahrgang 2017, 24.07.2017.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lehnerer, SM, Scheibe, F, Buchert, R, Kliesch, S & Meisel, A 2017, 'Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage', BMJ CASE REP, Jg. 2017. https://doi.org/10.1136/bcr-2017-220305

APA

Lehnerer, S. M., Scheibe, F., Buchert, R., Kliesch, S., & Meisel, A. (2017). Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage. BMJ CASE REP, 2017. https://doi.org/10.1136/bcr-2017-220305

Vancouver

Lehnerer SM, Scheibe F, Buchert R, Kliesch S, Meisel A. Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage. BMJ CASE REP. 2017 Jul 24;2017. https://doi.org/10.1136/bcr-2017-220305

Bibtex

@article{426c0c136faf4068b9b3f9f0afb862e6,
title = "Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage",
abstract = "We report the case of a 36-year-old woman with a subarachnoid haemorrhage (SAH) caused by a rupture of a right-sided middle cerebral artery aneurysm and subsequent malignant infarction of the right hemisphere leading to a persistent vegetative state and severe spastic tetraparesis with recurrent myocloni. Nine months after disease onset, the patient was transferred to our department for diagnostic and therapeutic re-evaluation. The poor clinical condition could not be explained by the brain lesion caused by the SAH or infarction. Moreover, glucose metabolism was normal in brain regions not affected by SAH and infarction as shown by positron emission tomography with (18)F-fluorodeoxyglucose. We terminated baclofen and reduced antiepileptics known to impair vigilance and cognitive functions. However, only after starting amantadine treatment we observed a stunning awakening of the patient fully orientated within days. Our findings warrant trials to investigate amantadine in the treatment of unresponsive wakefulness syndromes due to acute central nervous system diseases.",
keywords = "Journal Article",
author = "Lehnerer, {Sophie Mirabell} and Franziska Scheibe and Ralph Buchert and Stefan Kliesch and Andreas Meisel",
note = "{\textcopyright} BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",
year = "2017",
month = jul,
day = "24",
doi = "10.1136/bcr-2017-220305",
language = "English",
volume = "2017",
journal = "BMJ CASE REP",
issn = "1757-790X",
publisher = "BMJ PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage

AU - Lehnerer, Sophie Mirabell

AU - Scheibe, Franziska

AU - Buchert, Ralph

AU - Kliesch, Stefan

AU - Meisel, Andreas

N1 - © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2017/7/24

Y1 - 2017/7/24

N2 - We report the case of a 36-year-old woman with a subarachnoid haemorrhage (SAH) caused by a rupture of a right-sided middle cerebral artery aneurysm and subsequent malignant infarction of the right hemisphere leading to a persistent vegetative state and severe spastic tetraparesis with recurrent myocloni. Nine months after disease onset, the patient was transferred to our department for diagnostic and therapeutic re-evaluation. The poor clinical condition could not be explained by the brain lesion caused by the SAH or infarction. Moreover, glucose metabolism was normal in brain regions not affected by SAH and infarction as shown by positron emission tomography with (18)F-fluorodeoxyglucose. We terminated baclofen and reduced antiepileptics known to impair vigilance and cognitive functions. However, only after starting amantadine treatment we observed a stunning awakening of the patient fully orientated within days. Our findings warrant trials to investigate amantadine in the treatment of unresponsive wakefulness syndromes due to acute central nervous system diseases.

AB - We report the case of a 36-year-old woman with a subarachnoid haemorrhage (SAH) caused by a rupture of a right-sided middle cerebral artery aneurysm and subsequent malignant infarction of the right hemisphere leading to a persistent vegetative state and severe spastic tetraparesis with recurrent myocloni. Nine months after disease onset, the patient was transferred to our department for diagnostic and therapeutic re-evaluation. The poor clinical condition could not be explained by the brain lesion caused by the SAH or infarction. Moreover, glucose metabolism was normal in brain regions not affected by SAH and infarction as shown by positron emission tomography with (18)F-fluorodeoxyglucose. We terminated baclofen and reduced antiepileptics known to impair vigilance and cognitive functions. However, only after starting amantadine treatment we observed a stunning awakening of the patient fully orientated within days. Our findings warrant trials to investigate amantadine in the treatment of unresponsive wakefulness syndromes due to acute central nervous system diseases.

KW - Journal Article

U2 - 10.1136/bcr-2017-220305

DO - 10.1136/bcr-2017-220305

M3 - SCORING: Journal article

C2 - 28739616

VL - 2017

JO - BMJ CASE REP

JF - BMJ CASE REP

SN - 1757-790X

ER -