AVP dependent and independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid mediated vasopressin suppression.

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AVP dependent and independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid mediated vasopressin suppression. / Ufer, Friederike; Diederich, Sven; Pedersen, Erling B; Spranger, Joachim; Pfeiffer, Andreas Fh; Bähr, Volker; Mai, Knut.

in: CLIN ENDOCRINOL, 2012.

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@article{ebae319659fc4e08af88e9e62b8d4e95,
title = "AVP dependent and independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid mediated vasopressin suppression.",
abstract = "OBJECTIVE: Glucocorticoids seem to modify the release and effects of plasma vasopressin (pAVP). However, underlying processes are not well understood. This study aimed to evaluate the mechanism of the modulating effects of glucocorticoids on pAVP and renal water reabsorption. DESIGN: Fluid deprivation tests were performed without (d0) and after one (d1) and five days (d5) of oral prednisolone (Pred) pretreatment in a dosage relevant to drug therapy (30 mg/day). PATIENTS: Twelve healthy male volunteers participated in this trial. MEASUREMENTS: Plasma and urinary osmolality, pAVP, renin, aldosterone, plasma atrial natriuretic peptide (ANP) as well as urinary secretion of aquaporine-2 (AQP2) and prostaglandin E(2) (PGE2) were analysed. RESULTS: An appropriate rise of pAVP was observable during thirsting (p",
author = "Friederike Ufer and Sven Diederich and Pedersen, {Erling B} and Joachim Spranger and Pfeiffer, {Andreas Fh} and Volker B{\"a}hr and Knut Mai",
year = "2012",
language = "English",
journal = "CLIN ENDOCRINOL",
issn = "0300-0664",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - AVP dependent and independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid mediated vasopressin suppression.

AU - Ufer, Friederike

AU - Diederich, Sven

AU - Pedersen, Erling B

AU - Spranger, Joachim

AU - Pfeiffer, Andreas Fh

AU - Bähr, Volker

AU - Mai, Knut

PY - 2012

Y1 - 2012

N2 - OBJECTIVE: Glucocorticoids seem to modify the release and effects of plasma vasopressin (pAVP). However, underlying processes are not well understood. This study aimed to evaluate the mechanism of the modulating effects of glucocorticoids on pAVP and renal water reabsorption. DESIGN: Fluid deprivation tests were performed without (d0) and after one (d1) and five days (d5) of oral prednisolone (Pred) pretreatment in a dosage relevant to drug therapy (30 mg/day). PATIENTS: Twelve healthy male volunteers participated in this trial. MEASUREMENTS: Plasma and urinary osmolality, pAVP, renin, aldosterone, plasma atrial natriuretic peptide (ANP) as well as urinary secretion of aquaporine-2 (AQP2) and prostaglandin E(2) (PGE2) were analysed. RESULTS: An appropriate rise of pAVP was observable during thirsting (p

AB - OBJECTIVE: Glucocorticoids seem to modify the release and effects of plasma vasopressin (pAVP). However, underlying processes are not well understood. This study aimed to evaluate the mechanism of the modulating effects of glucocorticoids on pAVP and renal water reabsorption. DESIGN: Fluid deprivation tests were performed without (d0) and after one (d1) and five days (d5) of oral prednisolone (Pred) pretreatment in a dosage relevant to drug therapy (30 mg/day). PATIENTS: Twelve healthy male volunteers participated in this trial. MEASUREMENTS: Plasma and urinary osmolality, pAVP, renin, aldosterone, plasma atrial natriuretic peptide (ANP) as well as urinary secretion of aquaporine-2 (AQP2) and prostaglandin E(2) (PGE2) were analysed. RESULTS: An appropriate rise of pAVP was observable during thirsting (p

M3 - SCORING: Journal article

JO - CLIN ENDOCRINOL

JF - CLIN ENDOCRINOL

SN - 0300-0664

ER -