AVP dependent and independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid mediated vasopressin suppression.
Standard
AVP dependent and independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid mediated vasopressin suppression. / Ufer, Friederike; Diederich, Sven; Pedersen, Erling B; Spranger, Joachim; Pfeiffer, Andreas Fh; Bähr, Volker; Mai, Knut.
in: CLIN ENDOCRINOL, 2012.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - AVP dependent and independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid mediated vasopressin suppression.
AU - Ufer, Friederike
AU - Diederich, Sven
AU - Pedersen, Erling B
AU - Spranger, Joachim
AU - Pfeiffer, Andreas Fh
AU - Bähr, Volker
AU - Mai, Knut
PY - 2012
Y1 - 2012
N2 - OBJECTIVE: Glucocorticoids seem to modify the release and effects of plasma vasopressin (pAVP). However, underlying processes are not well understood. This study aimed to evaluate the mechanism of the modulating effects of glucocorticoids on pAVP and renal water reabsorption. DESIGN: Fluid deprivation tests were performed without (d0) and after one (d1) and five days (d5) of oral prednisolone (Pred) pretreatment in a dosage relevant to drug therapy (30 mg/day). PATIENTS: Twelve healthy male volunteers participated in this trial. MEASUREMENTS: Plasma and urinary osmolality, pAVP, renin, aldosterone, plasma atrial natriuretic peptide (ANP) as well as urinary secretion of aquaporine-2 (AQP2) and prostaglandin E(2) (PGE2) were analysed. RESULTS: An appropriate rise of pAVP was observable during thirsting (p
AB - OBJECTIVE: Glucocorticoids seem to modify the release and effects of plasma vasopressin (pAVP). However, underlying processes are not well understood. This study aimed to evaluate the mechanism of the modulating effects of glucocorticoids on pAVP and renal water reabsorption. DESIGN: Fluid deprivation tests were performed without (d0) and after one (d1) and five days (d5) of oral prednisolone (Pred) pretreatment in a dosage relevant to drug therapy (30 mg/day). PATIENTS: Twelve healthy male volunteers participated in this trial. MEASUREMENTS: Plasma and urinary osmolality, pAVP, renin, aldosterone, plasma atrial natriuretic peptide (ANP) as well as urinary secretion of aquaporine-2 (AQP2) and prostaglandin E(2) (PGE2) were analysed. RESULTS: An appropriate rise of pAVP was observable during thirsting (p
M3 - SCORING: Journal article
JO - CLIN ENDOCRINOL
JF - CLIN ENDOCRINOL
SN - 0300-0664
ER -