Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism.
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Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism. / Funk, Anneke; Mouna, Mhamdi; Will, Hans; Sirma, Hüseyin.
in: WORLD J GASTROENTERO, Jahrgang 13, Nr. 1, 1, 2007, S. 91-103.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism.
AU - Funk, Anneke
AU - Mouna, Mhamdi
AU - Will, Hans
AU - Sirma, Hüseyin
PY - 2007
Y1 - 2007
N2 - The human hepatitis B virus (HBV) and the duck hepatitis B virus (DHBV) share several fundamental features. Both viruses have a partially double-stranded DNA genome that is replicated via a RNA intermediate and the coding open reading frames (ORFs) overlap extensively. In addition, the genomic and structural organization, as well as replication and biological characteristics, are very similar in both viruses. Most of the key features of hepadnaviral infection were first discovered in the DHBV model system and subsequently confirmed for HBV. There are, however, several differences between human HBV and DHBV. This review will focus on the molecular and cellular biology, evolution, and host adaptation of the avian hepatitis B viruses with particular emphasis on DHBV as a model system.
AB - The human hepatitis B virus (HBV) and the duck hepatitis B virus (DHBV) share several fundamental features. Both viruses have a partially double-stranded DNA genome that is replicated via a RNA intermediate and the coding open reading frames (ORFs) overlap extensively. In addition, the genomic and structural organization, as well as replication and biological characteristics, are very similar in both viruses. Most of the key features of hepadnaviral infection were first discovered in the DHBV model system and subsequently confirmed for HBV. There are, however, several differences between human HBV and DHBV. This review will focus on the molecular and cellular biology, evolution, and host adaptation of the avian hepatitis B viruses with particular emphasis on DHBV as a model system.
M3 - SCORING: Zeitschriftenaufsatz
VL - 13
SP - 91
EP - 103
JO - WORLD J GASTROENTERO
JF - WORLD J GASTROENTERO
SN - 1007-9327
IS - 1
M1 - 1
ER -