Aversive learning in adolescents: modulation by amygdala-prefrontal and amygdala-hippocampal connectivity and neuroticism
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Aversive learning in adolescents: modulation by amygdala-prefrontal and amygdala-hippocampal connectivity and neuroticism. / Tzschoppe, Jelka; Nees, Frauke; Banaschewski, Tobias; Barker, Gareth J; Büchel, Christian; Conrod, Patricia J; Garavan, Hugh; Heinz, Andreas; Loth, Eva; Mann, Karl; Martinot, Jean-Luc; Smolka, Michael N; Gallinat, Jürgen; Ströhle, Aandreas; Struve, Maren; Rietschel, Marcella; Schumann, Gunter; Flor, Herta; IMAGEN Consortium.
in: NEUROPSYCHOPHARMACOL, Jahrgang 39, Nr. 4, 2014, S. 875-84.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Aversive learning in adolescents: modulation by amygdala-prefrontal and amygdala-hippocampal connectivity and neuroticism
AU - Tzschoppe, Jelka
AU - Nees, Frauke
AU - Banaschewski, Tobias
AU - Barker, Gareth J
AU - Büchel, Christian
AU - Conrod, Patricia J
AU - Garavan, Hugh
AU - Heinz, Andreas
AU - Loth, Eva
AU - Mann, Karl
AU - Martinot, Jean-Luc
AU - Smolka, Michael N
AU - Gallinat, Jürgen
AU - Ströhle, Aandreas
AU - Struve, Maren
AU - Rietschel, Marcella
AU - Schumann, Gunter
AU - Flor, Herta
AU - IMAGEN Consortium
PY - 2014
Y1 - 2014
N2 - Neuroticism involves a tendency for enhanced emotional and cognitive processing of negative affective stimuli and a propensity to worry and be anxious. It is known that this trait modulates fear learning and the activation of brain regions involved in it such as the amygdala, hippocampus, and prefrontal cortex and their connectivity. Thirty-nine (21 female) 14-year-old healthy adolescents participated in functional magnetic resonance imaging (fMRI) of aversive pavlovian differential delay conditioning. An unpleasant sound served as unconditioned stimulus (US) and pictures of neutral male faces as conditioned stimuli (CS+ followed by the US in 50% of the cases; CS- never followed by the US). During acquisition (CS+/- differentiation), higher levels of neuroticism were associated with a stronger interaction between the right amygdala and the right hippocampus as well as the right amygdala and prefrontal cortical regions, specifically ventromedial prefrontal cortex, dorsolateral prefrontal cortex, and anterior cingulate cortex. The association of stronger conditionability of fear and connectivity of brain regions related to consolidation of fear associations and neuroticism points to underlying mechanisms of the enhanced propensity for anxiety disorders in highly neurotic participants. This is especially important in adolescence, a vulnerable time for the onset of mental disorders such as anxiety disorders.
AB - Neuroticism involves a tendency for enhanced emotional and cognitive processing of negative affective stimuli and a propensity to worry and be anxious. It is known that this trait modulates fear learning and the activation of brain regions involved in it such as the amygdala, hippocampus, and prefrontal cortex and their connectivity. Thirty-nine (21 female) 14-year-old healthy adolescents participated in functional magnetic resonance imaging (fMRI) of aversive pavlovian differential delay conditioning. An unpleasant sound served as unconditioned stimulus (US) and pictures of neutral male faces as conditioned stimuli (CS+ followed by the US in 50% of the cases; CS- never followed by the US). During acquisition (CS+/- differentiation), higher levels of neuroticism were associated with a stronger interaction between the right amygdala and the right hippocampus as well as the right amygdala and prefrontal cortical regions, specifically ventromedial prefrontal cortex, dorsolateral prefrontal cortex, and anterior cingulate cortex. The association of stronger conditionability of fear and connectivity of brain regions related to consolidation of fear associations and neuroticism points to underlying mechanisms of the enhanced propensity for anxiety disorders in highly neurotic participants. This is especially important in adolescence, a vulnerable time for the onset of mental disorders such as anxiety disorders.
U2 - 10.1038/npp.2013.287
DO - 10.1038/npp.2013.287
M3 - SCORING: Journal article
C2 - 24126454
VL - 39
SP - 875
EP - 884
JO - NEUROPSYCHOPHARMACOL
JF - NEUROPSYCHOPHARMACOL
SN - 0893-133X
IS - 4
ER -