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Augmentation index and the evolution of aortic disease in marfan-like syndromes.

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Augmentation index and the evolution of aortic disease in marfan-like syndromes. / Mortensen, Kai; Baulmann, Johannes; Rybczynski, Meike; Sheikhzadeh, Sara; Aydin, Muhammet Ali; Treede, Hendrik; Dombrowski, Ellen; Kühne, Kristin; Peitsmeyer, Philipp; Habermann, Christian; Robinson, Peter N; Stuhrmann, Manfred; Berger, Jürgen; Meinertz, Thomas; Von Kodolitsch, Yskert.

in: AM J HYPERTENS, Jahrgang 23, Nr. 7, 7, 15.04.2010, S. 716-724.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mortensen, K, Baulmann, J, Rybczynski, M, Sheikhzadeh, S, Aydin, MA, Treede, H, Dombrowski, E, Kühne, K, Peitsmeyer, P, Habermann, C, Robinson, PN, Stuhrmann, M, Berger, J, Meinertz, T & Von Kodolitsch, Y 2010, 'Augmentation index and the evolution of aortic disease in marfan-like syndromes.', AM J HYPERTENS, Jg. 23, Nr. 7, 7, S. 716-724. <http://www.ncbi.nlm.nih.gov/pubmed/20395939>

APA

Mortensen, K., Baulmann, J., Rybczynski, M., Sheikhzadeh, S., Aydin, M. A., Treede, H., Dombrowski, E., Kühne, K., Peitsmeyer, P., Habermann, C., Robinson, P. N., Stuhrmann, M., Berger, J., Meinertz, T., & Von Kodolitsch, Y. (2010). Augmentation index and the evolution of aortic disease in marfan-like syndromes. AM J HYPERTENS, 23(7), 716-724. [7]. http://www.ncbi.nlm.nih.gov/pubmed/20395939

Vancouver

Mortensen K, Baulmann J, Rybczynski M, Sheikhzadeh S, Aydin MA, Treede H et al. Augmentation index and the evolution of aortic disease in marfan-like syndromes. AM J HYPERTENS. 2010 Apr 15;23(7):716-724. 7.

Bibtex

@article{b657ae04d9cc4112a10ef99877227852,
title = "Augmentation index and the evolution of aortic disease in marfan-like syndromes.",
abstract = "BACKGROUND:The augmentation index at a heart rate of 75 beats/min (AIx@HR75) and central pulse pressure (CPP) can be measured noninvasively with applanation tonometry (APT). In this observational study, we investigated the relationship between AIx@HR75, CPP and aortic disease in patients with Marfan-like syndromes.METHODS:We performed APT in 78 consecutive patients in whom classic Marfan syndrome (MFS) had been excluded (46 men and 32 women aged 34 +/- 13 years). These patients comprised 9 persons with MFS-like habitus, 6 with a bicuspid aortic valve (BAV), 5 with MASS phenotype, 3 with vascular type of Ehlers-Danlos syndrome (EDS), 3 with familial thoracic aortic aneurysm, 2 with Loeys-Dietz syndrome (LDS), 1 with mitral valve prolapse syndrome, 1 with familial ectopia lentis, and 48 persons with Marfan-like features but no defined syndrome. During 20 +/- 18 months after APT, we observed progression of aortic diameters in 15 patients, and aortic surgery or aortic dissection in 3 individuals.RESULTS:All 11 patients with Marfan-like syndromes and progression of aortic disease exhibited AIx@HR75 > or =11%, including 8 individuals with aortic diameters < or =95th percentile of normal at baseline. Similarly, all 7 individuals without any defined syndrome but progression of aortic diameters exhibited AIx@HR75 >11%, including 6 individuals with aortic diameters < or =95th percentile at the time of APT. Aortic disease did not evolve at AIx@HR75 <11%. CPP is also related to aortic disease progression.CONCLUSIONS:Aortic disease evolution relates to AIx@HR75 and CPP in Marfan like syndromes. Larger studies with comprehensive clinical and echocardiographic follow-up over long time intervals will be required to establish APT for prediction of aortic disease evolution in Marfan-like syndromes.",
author = "Kai Mortensen and Johannes Baulmann and Meike Rybczynski and Sara Sheikhzadeh and Aydin, {Muhammet Ali} and Hendrik Treede and Ellen Dombrowski and Kristin K{\"u}hne and Philipp Peitsmeyer and Christian Habermann and Robinson, {Peter N} and Manfred Stuhrmann and J{\"u}rgen Berger and Thomas Meinertz and {Von Kodolitsch}, Yskert",
year = "2010",
month = apr,
day = "15",
language = "Deutsch",
volume = "23",
pages = "716--724",
journal = "AM J HYPERTENS",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Augmentation index and the evolution of aortic disease in marfan-like syndromes.

AU - Mortensen, Kai

AU - Baulmann, Johannes

AU - Rybczynski, Meike

AU - Sheikhzadeh, Sara

AU - Aydin, Muhammet Ali

AU - Treede, Hendrik

AU - Dombrowski, Ellen

AU - Kühne, Kristin

AU - Peitsmeyer, Philipp

AU - Habermann, Christian

AU - Robinson, Peter N

AU - Stuhrmann, Manfred

AU - Berger, Jürgen

AU - Meinertz, Thomas

AU - Von Kodolitsch, Yskert

PY - 2010/4/15

Y1 - 2010/4/15

N2 - BACKGROUND:The augmentation index at a heart rate of 75 beats/min (AIx@HR75) and central pulse pressure (CPP) can be measured noninvasively with applanation tonometry (APT). In this observational study, we investigated the relationship between AIx@HR75, CPP and aortic disease in patients with Marfan-like syndromes.METHODS:We performed APT in 78 consecutive patients in whom classic Marfan syndrome (MFS) had been excluded (46 men and 32 women aged 34 +/- 13 years). These patients comprised 9 persons with MFS-like habitus, 6 with a bicuspid aortic valve (BAV), 5 with MASS phenotype, 3 with vascular type of Ehlers-Danlos syndrome (EDS), 3 with familial thoracic aortic aneurysm, 2 with Loeys-Dietz syndrome (LDS), 1 with mitral valve prolapse syndrome, 1 with familial ectopia lentis, and 48 persons with Marfan-like features but no defined syndrome. During 20 +/- 18 months after APT, we observed progression of aortic diameters in 15 patients, and aortic surgery or aortic dissection in 3 individuals.RESULTS:All 11 patients with Marfan-like syndromes and progression of aortic disease exhibited AIx@HR75 > or =11%, including 8 individuals with aortic diameters < or =95th percentile of normal at baseline. Similarly, all 7 individuals without any defined syndrome but progression of aortic diameters exhibited AIx@HR75 >11%, including 6 individuals with aortic diameters < or =95th percentile at the time of APT. Aortic disease did not evolve at AIx@HR75 <11%. CPP is also related to aortic disease progression.CONCLUSIONS:Aortic disease evolution relates to AIx@HR75 and CPP in Marfan like syndromes. Larger studies with comprehensive clinical and echocardiographic follow-up over long time intervals will be required to establish APT for prediction of aortic disease evolution in Marfan-like syndromes.

AB - BACKGROUND:The augmentation index at a heart rate of 75 beats/min (AIx@HR75) and central pulse pressure (CPP) can be measured noninvasively with applanation tonometry (APT). In this observational study, we investigated the relationship between AIx@HR75, CPP and aortic disease in patients with Marfan-like syndromes.METHODS:We performed APT in 78 consecutive patients in whom classic Marfan syndrome (MFS) had been excluded (46 men and 32 women aged 34 +/- 13 years). These patients comprised 9 persons with MFS-like habitus, 6 with a bicuspid aortic valve (BAV), 5 with MASS phenotype, 3 with vascular type of Ehlers-Danlos syndrome (EDS), 3 with familial thoracic aortic aneurysm, 2 with Loeys-Dietz syndrome (LDS), 1 with mitral valve prolapse syndrome, 1 with familial ectopia lentis, and 48 persons with Marfan-like features but no defined syndrome. During 20 +/- 18 months after APT, we observed progression of aortic diameters in 15 patients, and aortic surgery or aortic dissection in 3 individuals.RESULTS:All 11 patients with Marfan-like syndromes and progression of aortic disease exhibited AIx@HR75 > or =11%, including 8 individuals with aortic diameters < or =95th percentile of normal at baseline. Similarly, all 7 individuals without any defined syndrome but progression of aortic diameters exhibited AIx@HR75 >11%, including 6 individuals with aortic diameters < or =95th percentile at the time of APT. Aortic disease did not evolve at AIx@HR75 <11%. CPP is also related to aortic disease progression.CONCLUSIONS:Aortic disease evolution relates to AIx@HR75 and CPP in Marfan like syndromes. Larger studies with comprehensive clinical and echocardiographic follow-up over long time intervals will be required to establish APT for prediction of aortic disease evolution in Marfan-like syndromes.

UR - http://ajh.oxfordjournals.org/content/23/7/716.long

M3 - SCORING: Zeitschriftenaufsatz

VL - 23

SP - 716

EP - 724

JO - AM J HYPERTENS

JF - AM J HYPERTENS

SN - 0895-7061

IS - 7

M1 - 7

ER -