Auditory evoked bursts in mouse visual cortex during isoflurane anesthesia.
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Auditory evoked bursts in mouse visual cortex during isoflurane anesthesia. / Land, Rüdiger; Engler, Gerhard; Král, Andrej; Engel, Andreas K.
in: PLOS ONE, Jahrgang 7, Nr. 11, 11, 2012, S. 49855.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Auditory evoked bursts in mouse visual cortex during isoflurane anesthesia.
AU - Land, Rüdiger
AU - Engler, Gerhard
AU - Král, Andrej
AU - Engel, Andreas K.
PY - 2012
Y1 - 2012
N2 - General anesthesia is not a uniform state of the brain. Ongoing activity differs between light and deep anesthesia and cortical response properties are modulated in dependence of anesthetic dosage. We investigated how anesthesia level affects cross-modal interactions in primary sensory cortex. To examine this, we continuously measured the effects of visual and auditory stimulation during increasing and decreasing isoflurane level in the mouse visual cortex and the subiculum (from baseline at 0.7 to 2.5 vol % and reverse). Auditory evoked burst activity occurred in visual cortex after a transition during increase of anesthesia level. At the same time, auditory and visual evoked bursts occurred in the subiculum, even though the subiculum was unresponsive to both stimuli previous to the transition. This altered sensory excitability was linked to the presence of burst suppression activity in cortex, and to a regular slow burst suppression rhythm (~0.2 Hz) in the subiculum. The effect disappeared during return to light anesthesia. The results show that pseudo-heteromodal sensory burst responses can appear in brain structures as an effect of an anesthesia induced state change.
AB - General anesthesia is not a uniform state of the brain. Ongoing activity differs between light and deep anesthesia and cortical response properties are modulated in dependence of anesthetic dosage. We investigated how anesthesia level affects cross-modal interactions in primary sensory cortex. To examine this, we continuously measured the effects of visual and auditory stimulation during increasing and decreasing isoflurane level in the mouse visual cortex and the subiculum (from baseline at 0.7 to 2.5 vol % and reverse). Auditory evoked burst activity occurred in visual cortex after a transition during increase of anesthesia level. At the same time, auditory and visual evoked bursts occurred in the subiculum, even though the subiculum was unresponsive to both stimuli previous to the transition. This altered sensory excitability was linked to the presence of burst suppression activity in cortex, and to a regular slow burst suppression rhythm (~0.2 Hz) in the subiculum. The effect disappeared during return to light anesthesia. The results show that pseudo-heteromodal sensory burst responses can appear in brain structures as an effect of an anesthesia induced state change.
KW - Animals
KW - Photic Stimulation
KW - Mice
KW - Electroencephalography
KW - Acoustic Stimulation
KW - Anesthesia, General
KW - Evoked Potentials, Auditory/drug effects
KW - Isoflurane/administration & dosage
KW - Respiratory Burst/drug effects
KW - Visual Cortex/drug effects/physiology
KW - Animals
KW - Photic Stimulation
KW - Mice
KW - Electroencephalography
KW - Acoustic Stimulation
KW - Anesthesia, General
KW - Evoked Potentials, Auditory/drug effects
KW - Isoflurane/administration & dosage
KW - Respiratory Burst/drug effects
KW - Visual Cortex/drug effects/physiology
U2 - 10.1371/journal.pone.0049855
DO - 10.1371/journal.pone.0049855
M3 - SCORING: Journal article
VL - 7
SP - 49855
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 11
M1 - 11
ER -
