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Atrial fibrillation patterns and risks of subsequent stroke, heart failure, or death in the community

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Atrial fibrillation patterns and risks of subsequent stroke, heart failure, or death in the community. / Lubitz, Steven A; Moser, Carlee; Sullivan, Lisa; Rienstra, Michiel; Fontes, João D; Villalon, Mark L; Pai, Manju; McManus, David D; Schnabel, Renate B; Magnani, Jared W; Yin, Xiaoyan; Levy, Daniel; Pencina, Michael J; Larson, Martin G; Ellinor, Patrick T; Benjamin, Emelia J.

in: J AM HEART ASSOC, Jahrgang 2, Nr. 5, 03.09.2013, S. e000126.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lubitz, SA, Moser, C, Sullivan, L, Rienstra, M, Fontes, JD, Villalon, ML, Pai, M, McManus, DD, Schnabel, RB, Magnani, JW, Yin, X, Levy, D, Pencina, MJ, Larson, MG, Ellinor, PT & Benjamin, EJ 2013, 'Atrial fibrillation patterns and risks of subsequent stroke, heart failure, or death in the community', J AM HEART ASSOC, Jg. 2, Nr. 5, S. e000126. https://doi.org/10.1161/JAHA.113.000126

APA

Lubitz, S. A., Moser, C., Sullivan, L., Rienstra, M., Fontes, J. D., Villalon, M. L., Pai, M., McManus, D. D., Schnabel, R. B., Magnani, J. W., Yin, X., Levy, D., Pencina, M. J., Larson, M. G., Ellinor, P. T., & Benjamin, E. J. (2013). Atrial fibrillation patterns and risks of subsequent stroke, heart failure, or death in the community. J AM HEART ASSOC, 2(5), e000126. https://doi.org/10.1161/JAHA.113.000126

Vancouver

Lubitz SA, Moser C, Sullivan L, Rienstra M, Fontes JD, Villalon ML et al. Atrial fibrillation patterns and risks of subsequent stroke, heart failure, or death in the community. J AM HEART ASSOC. 2013 Sep 3;2(5):e000126. https://doi.org/10.1161/JAHA.113.000126

Bibtex

@article{aa3c39c25d8a48368fe8585b532427ee,
title = "Atrial fibrillation patterns and risks of subsequent stroke, heart failure, or death in the community",
abstract = "BACKGROUND: Atrial fibrillation (AF) patterns and their relations with long-term prognosis are uncertain, partly because pattern definitions are challenging to implement in longitudinal data sets. We developed a novel AF classification algorithm and examined AF patterns and outcomes in the community.METHODS AND RESULTS: We characterized AF patterns between 1980 and 2005 among Framingham Heart Study participants who survived ≥ 1 year after diagnosis. We classified participants based on their pattern within the first 2 years after detection as having AF without recurrence, recurrent AF, or sustained AF. We examined associations between AF patterns and 10-year survival using proportional hazards regression. Among 612 individuals with AF, mean age was 72.5 ± 10.8 years, and 53% were men. Of these, 478 participants had ≥ 2 electrocardiograms (median, 3; limits 2 to 23) within 2 years after initial AF and were classified as having AF without 2-year recurrence (n = 63, 10%), recurrent AF (n = 162, 26%) or sustained AF (n = 207, 34%), although some (n = 46, 8%) were indeterminate. Of 432 classified participants, 363 died, 75 had strokes, and 110 were diagnosed with heart failure during the next 10 years. Relative to individuals without AF recurrence, the multivariable-adjusted mortality was higher among people with recurrent AF (hazard ratio [HR], 2.04; 95% confidence interval [CI], 1.26 to 3.29) and sustained AF (HR, 2.36; 95% CI, 1.49 to 3.75).CONCLUSIONS: In our community-based AF sample, only 10% had AF without early-term (2-year) recurrence. Compared with individuals without 2-year AF recurrences, the 10-year prognosis was worse for individuals with either sustained or recurrent AF. Our proposed AF classification algorithm may be applicable in longitudinal data sets.",
keywords = "Aged, Atrial Fibrillation/complications, Female, Heart Failure/etiology, Humans, Male, Prognosis, Stroke/etiology",
author = "Lubitz, {Steven A} and Carlee Moser and Lisa Sullivan and Michiel Rienstra and Fontes, {Jo{\~a}o D} and Villalon, {Mark L} and Manju Pai and McManus, {David D} and Schnabel, {Renate B} and Magnani, {Jared W} and Xiaoyan Yin and Daniel Levy and Pencina, {Michael J} and Larson, {Martin G} and Ellinor, {Patrick T} and Benjamin, {Emelia J}",
year = "2013",
month = sep,
day = "3",
doi = "10.1161/JAHA.113.000126",
language = "English",
volume = "2",
pages = "e000126",
journal = "J AM HEART ASSOC",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Atrial fibrillation patterns and risks of subsequent stroke, heart failure, or death in the community

AU - Lubitz, Steven A

AU - Moser, Carlee

AU - Sullivan, Lisa

AU - Rienstra, Michiel

AU - Fontes, João D

AU - Villalon, Mark L

AU - Pai, Manju

AU - McManus, David D

AU - Schnabel, Renate B

AU - Magnani, Jared W

AU - Yin, Xiaoyan

AU - Levy, Daniel

AU - Pencina, Michael J

AU - Larson, Martin G

AU - Ellinor, Patrick T

AU - Benjamin, Emelia J

PY - 2013/9/3

Y1 - 2013/9/3

N2 - BACKGROUND: Atrial fibrillation (AF) patterns and their relations with long-term prognosis are uncertain, partly because pattern definitions are challenging to implement in longitudinal data sets. We developed a novel AF classification algorithm and examined AF patterns and outcomes in the community.METHODS AND RESULTS: We characterized AF patterns between 1980 and 2005 among Framingham Heart Study participants who survived ≥ 1 year after diagnosis. We classified participants based on their pattern within the first 2 years after detection as having AF without recurrence, recurrent AF, or sustained AF. We examined associations between AF patterns and 10-year survival using proportional hazards regression. Among 612 individuals with AF, mean age was 72.5 ± 10.8 years, and 53% were men. Of these, 478 participants had ≥ 2 electrocardiograms (median, 3; limits 2 to 23) within 2 years after initial AF and were classified as having AF without 2-year recurrence (n = 63, 10%), recurrent AF (n = 162, 26%) or sustained AF (n = 207, 34%), although some (n = 46, 8%) were indeterminate. Of 432 classified participants, 363 died, 75 had strokes, and 110 were diagnosed with heart failure during the next 10 years. Relative to individuals without AF recurrence, the multivariable-adjusted mortality was higher among people with recurrent AF (hazard ratio [HR], 2.04; 95% confidence interval [CI], 1.26 to 3.29) and sustained AF (HR, 2.36; 95% CI, 1.49 to 3.75).CONCLUSIONS: In our community-based AF sample, only 10% had AF without early-term (2-year) recurrence. Compared with individuals without 2-year AF recurrences, the 10-year prognosis was worse for individuals with either sustained or recurrent AF. Our proposed AF classification algorithm may be applicable in longitudinal data sets.

AB - BACKGROUND: Atrial fibrillation (AF) patterns and their relations with long-term prognosis are uncertain, partly because pattern definitions are challenging to implement in longitudinal data sets. We developed a novel AF classification algorithm and examined AF patterns and outcomes in the community.METHODS AND RESULTS: We characterized AF patterns between 1980 and 2005 among Framingham Heart Study participants who survived ≥ 1 year after diagnosis. We classified participants based on their pattern within the first 2 years after detection as having AF without recurrence, recurrent AF, or sustained AF. We examined associations between AF patterns and 10-year survival using proportional hazards regression. Among 612 individuals with AF, mean age was 72.5 ± 10.8 years, and 53% were men. Of these, 478 participants had ≥ 2 electrocardiograms (median, 3; limits 2 to 23) within 2 years after initial AF and were classified as having AF without 2-year recurrence (n = 63, 10%), recurrent AF (n = 162, 26%) or sustained AF (n = 207, 34%), although some (n = 46, 8%) were indeterminate. Of 432 classified participants, 363 died, 75 had strokes, and 110 were diagnosed with heart failure during the next 10 years. Relative to individuals without AF recurrence, the multivariable-adjusted mortality was higher among people with recurrent AF (hazard ratio [HR], 2.04; 95% confidence interval [CI], 1.26 to 3.29) and sustained AF (HR, 2.36; 95% CI, 1.49 to 3.75).CONCLUSIONS: In our community-based AF sample, only 10% had AF without early-term (2-year) recurrence. Compared with individuals without 2-year AF recurrences, the 10-year prognosis was worse for individuals with either sustained or recurrent AF. Our proposed AF classification algorithm may be applicable in longitudinal data sets.

KW - Aged

KW - Atrial Fibrillation/complications

KW - Female

KW - Heart Failure/etiology

KW - Humans

KW - Male

KW - Prognosis

KW - Stroke/etiology

U2 - 10.1161/JAHA.113.000126

DO - 10.1161/JAHA.113.000126

M3 - SCORING: Journal article

C2 - 24002369

VL - 2

SP - e000126

JO - J AM HEART ASSOC

JF - J AM HEART ASSOC

SN - 2047-9980

IS - 5

ER -