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Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study)

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Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study). / Magnussen, Christina; Ojeda, Francisco M; Wild, Philipp S; Sörensen, Nils; Rostock, Thomas; Hoffmann, Boris A; Prochaska, Jürgen; Lackner, Karl J; Beutel, Manfred E; Blettner, Maria; Pfeiffer, Norbert; Rzayeva, Nargiz; Sinning, Christoph R; Blankenberg, Stefan; Münzel, Thomas; Zeller, Tanja; Schnabel, Renate B.

in: AM J CARDIOL, Jahrgang 122, Nr. 1, 01.07.2018, S. 76-82.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung

Harvard

Magnussen, C, Ojeda, FM, Wild, PS, Sörensen, N, Rostock, T, Hoffmann, BA, Prochaska, J, Lackner, KJ, Beutel, ME, Blettner, M, Pfeiffer, N, Rzayeva, N, Sinning, CR, Blankenberg, S, Münzel, T, Zeller, T & Schnabel, RB 2018, 'Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study)', AM J CARDIOL, Jg. 122, Nr. 1, S. 76-82. https://doi.org/10.1016/j.amjcard.2018.03.028

APA

Magnussen, C., Ojeda, F. M., Wild, P. S., Sörensen, N., Rostock, T., Hoffmann, B. A., Prochaska, J., Lackner, K. J., Beutel, M. E., Blettner, M., Pfeiffer, N., Rzayeva, N., Sinning, C. R., Blankenberg, S., Münzel, T., Zeller, T., & Schnabel, R. B. (2018). Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study). AM J CARDIOL, 122(1), 76-82. https://doi.org/10.1016/j.amjcard.2018.03.028

Vancouver

Magnussen C, Ojeda FM, Wild PS, Sörensen N, Rostock T, Hoffmann BA et al. Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study). AM J CARDIOL. 2018 Jul 1;122(1):76-82. https://doi.org/10.1016/j.amjcard.2018.03.028

Bibtex

@article{6f29c0532e414909a85675c29fb3aeb1,
title = "Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study)",
abstract = "Sex differences in cardiovascular risk factors, cardiac structure and function, and disease and symptom burden in the common arrhythmia atrial fibrillation (AF) have not been investigated systematically at the population level. Cross-sectional data of 14,796 subjects (age range 35 to 74 years, 50.5% men) from the population-based Gutenberg Health Study were examined to show the distribution of cardiovascular risk factors by AF status and sex, and to determine sex-specific predictors for AF. The prevalence of AF was higher in men (4.3%) than in women (1.9%). Men had a worse cardiovascular risk factor profile, a higher prevalence of cardiovascular disease, but fewer symptoms than women. Age-adjusted Cox regressions showed sex interactions in the association of high-density lipoprotein-cholesterol, triglycerides, diabetes mellitus, coronary artery disease, myocardial infarction, generalized anxiety disorder, and heart rate with AF. After multivariable adjustment, sex interactions were seen for thickness of interventricular end-diastolic septum, odds ratio (OR) per standard deviation (SD), 95% confidence interval women: 0.9 (0.8, 1.1), men: 1.2 (1.1, 1.4), interaction p value = 0.02; left atrial diameter index, OR per SD women: 1.5 (1.3, 1.8), men: 1.9 (1.7, 2.1), interaction p value = 0.03; and myocardial infarction, OR women: 2.7 (1.3, 5.6), men: 0.7 (0.5, 1.1), interaction p value = 0.002. In conclusion, in our large cohort, we observed substantial sex differences in AF distribution and clinical characteristics including comorbidities, symptom burden, and structural cardiac changes.",
keywords = "Adult, Aged, Atrial Fibrillation/diagnosis, Cross-Sectional Studies, Echocardiography, Electrocardiography, Female, Follow-Up Studies, Germany/epidemiology, Heart Ventricles/diagnostic imaging, Humans, Incidence, Male, Middle Aged, Population Surveillance, Prevalence, Retrospective Studies, Risk Assessment/methods, Risk Factors, Sex Factors, Survival Rate/trends, Ventricular Function, Left/physiology",
author = "Christina Magnussen and Ojeda, {Francisco M} and Wild, {Philipp S} and Nils S{\"o}rensen and Thomas Rostock and Hoffmann, {Boris A} and J{\"u}rgen Prochaska and Lackner, {Karl J} and Beutel, {Manfred E} and Maria Blettner and Norbert Pfeiffer and Nargiz Rzayeva and Sinning, {Christoph R} and Stefan Blankenberg and Thomas M{\"u}nzel and Tanja Zeller and Schnabel, {Renate B}",
note = "Copyright {\textcopyright} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = jul,
day = "1",
doi = "10.1016/j.amjcard.2018.03.028",
language = "English",
volume = "122",
pages = "76--82",
journal = "AM J CARDIOL",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study)

AU - Magnussen, Christina

AU - Ojeda, Francisco M

AU - Wild, Philipp S

AU - Sörensen, Nils

AU - Rostock, Thomas

AU - Hoffmann, Boris A

AU - Prochaska, Jürgen

AU - Lackner, Karl J

AU - Beutel, Manfred E

AU - Blettner, Maria

AU - Pfeiffer, Norbert

AU - Rzayeva, Nargiz

AU - Sinning, Christoph R

AU - Blankenberg, Stefan

AU - Münzel, Thomas

AU - Zeller, Tanja

AU - Schnabel, Renate B

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Sex differences in cardiovascular risk factors, cardiac structure and function, and disease and symptom burden in the common arrhythmia atrial fibrillation (AF) have not been investigated systematically at the population level. Cross-sectional data of 14,796 subjects (age range 35 to 74 years, 50.5% men) from the population-based Gutenberg Health Study were examined to show the distribution of cardiovascular risk factors by AF status and sex, and to determine sex-specific predictors for AF. The prevalence of AF was higher in men (4.3%) than in women (1.9%). Men had a worse cardiovascular risk factor profile, a higher prevalence of cardiovascular disease, but fewer symptoms than women. Age-adjusted Cox regressions showed sex interactions in the association of high-density lipoprotein-cholesterol, triglycerides, diabetes mellitus, coronary artery disease, myocardial infarction, generalized anxiety disorder, and heart rate with AF. After multivariable adjustment, sex interactions were seen for thickness of interventricular end-diastolic septum, odds ratio (OR) per standard deviation (SD), 95% confidence interval women: 0.9 (0.8, 1.1), men: 1.2 (1.1, 1.4), interaction p value = 0.02; left atrial diameter index, OR per SD women: 1.5 (1.3, 1.8), men: 1.9 (1.7, 2.1), interaction p value = 0.03; and myocardial infarction, OR women: 2.7 (1.3, 5.6), men: 0.7 (0.5, 1.1), interaction p value = 0.002. In conclusion, in our large cohort, we observed substantial sex differences in AF distribution and clinical characteristics including comorbidities, symptom burden, and structural cardiac changes.

AB - Sex differences in cardiovascular risk factors, cardiac structure and function, and disease and symptom burden in the common arrhythmia atrial fibrillation (AF) have not been investigated systematically at the population level. Cross-sectional data of 14,796 subjects (age range 35 to 74 years, 50.5% men) from the population-based Gutenberg Health Study were examined to show the distribution of cardiovascular risk factors by AF status and sex, and to determine sex-specific predictors for AF. The prevalence of AF was higher in men (4.3%) than in women (1.9%). Men had a worse cardiovascular risk factor profile, a higher prevalence of cardiovascular disease, but fewer symptoms than women. Age-adjusted Cox regressions showed sex interactions in the association of high-density lipoprotein-cholesterol, triglycerides, diabetes mellitus, coronary artery disease, myocardial infarction, generalized anxiety disorder, and heart rate with AF. After multivariable adjustment, sex interactions were seen for thickness of interventricular end-diastolic septum, odds ratio (OR) per standard deviation (SD), 95% confidence interval women: 0.9 (0.8, 1.1), men: 1.2 (1.1, 1.4), interaction p value = 0.02; left atrial diameter index, OR per SD women: 1.5 (1.3, 1.8), men: 1.9 (1.7, 2.1), interaction p value = 0.03; and myocardial infarction, OR women: 2.7 (1.3, 5.6), men: 0.7 (0.5, 1.1), interaction p value = 0.002. In conclusion, in our large cohort, we observed substantial sex differences in AF distribution and clinical characteristics including comorbidities, symptom burden, and structural cardiac changes.

KW - Adult

KW - Aged

KW - Atrial Fibrillation/diagnosis

KW - Cross-Sectional Studies

KW - Echocardiography

KW - Electrocardiography

KW - Female

KW - Follow-Up Studies

KW - Germany/epidemiology

KW - Heart Ventricles/diagnostic imaging

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Population Surveillance

KW - Prevalence

KW - Retrospective Studies

KW - Risk Assessment/methods

KW - Risk Factors

KW - Sex Factors

KW - Survival Rate/trends

KW - Ventricular Function, Left/physiology

U2 - 10.1016/j.amjcard.2018.03.028

DO - 10.1016/j.amjcard.2018.03.028

M3 - SCORING: Journal article

C2 - 29706202

VL - 122

SP - 76

EP - 82

JO - AM J CARDIOL

JF - AM J CARDIOL

SN - 0002-9149

IS - 1

ER -