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Atrial fibrillation ablation strategies and outcome in patients with heart failure: insights from the German ablation registry

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Atrial fibrillation ablation strategies and outcome in patients with heart failure: insights from the German ablation registry. / Eitel, Charlotte; Ince, Hueseyin; Brachmann, Johannes; Kuck, Karl-Heinz; Willems, Stephan; Gerds-Li, Jin-Hong; Tebbenjohanns, Juergen; Richardt, Gert; Hochadel, Matthias; Senges, Jochen; Tilz, Roland R.

in: CLIN RES CARDIOL, Jahrgang 108, Nr. 7, 07.2019, S. 815-823.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Eitel, C, Ince, H, Brachmann, J, Kuck, K-H, Willems, S, Gerds-Li, J-H, Tebbenjohanns, J, Richardt, G, Hochadel, M, Senges, J & Tilz, RR 2019, 'Atrial fibrillation ablation strategies and outcome in patients with heart failure: insights from the German ablation registry', CLIN RES CARDIOL, Jg. 108, Nr. 7, S. 815-823. https://doi.org/10.1007/s00392-019-01411-3

APA

Eitel, C., Ince, H., Brachmann, J., Kuck, K-H., Willems, S., Gerds-Li, J-H., Tebbenjohanns, J., Richardt, G., Hochadel, M., Senges, J., & Tilz, R. R. (2019). Atrial fibrillation ablation strategies and outcome in patients with heart failure: insights from the German ablation registry. CLIN RES CARDIOL, 108(7), 815-823. https://doi.org/10.1007/s00392-019-01411-3

Vancouver

Eitel C, Ince H, Brachmann J, Kuck K-H, Willems S, Gerds-Li J-H et al. Atrial fibrillation ablation strategies and outcome in patients with heart failure: insights from the German ablation registry. CLIN RES CARDIOL. 2019 Jul;108(7):815-823. https://doi.org/10.1007/s00392-019-01411-3

Bibtex

@article{c782e1136dac42dbac0ea3ba2f925548,
title = "Atrial fibrillation ablation strategies and outcome in patients with heart failure: insights from the German ablation registry",
abstract = "BACKGROUND: Heart failure (HF) and atrial fibrillation (AF) often coexist, but data on the prognostic value of differing ablation strategies according to left ventricular ejection fraction (LVEF) are rare.METHODS AND RESULTS: From January 2007 until January 2010, 728 patients with HF were enrolled in the multi-center German ablation registry prior to AF catheter ablation. Patients were divided into three groups according to LVEF: HF with preserved LVEF (≥ 50%, HFpEF, n = 333), mid-range LVEF (40-49%, HFmrEF, n = 207), and reduced LVEF (< 40%, HFrEF, n = 188). Ablation strategies differed significantly between the three groups with the majority of patients with HFpEF (83.4%) and HFmrEF (78.4%) undergoing circumferential pulmonary vein isolation vs. 48.9% of patients with HFrEF. The latter underwent ablation of the atrioventricular (AV) node in 47.3%. Major complications did not differ between the groups. Kaplan-Meier survival analysis demonstrated a significant mortality increase in patients with HFrEF (6.1% in HFrEF vs. 1.5% in HFmrEF vs. 1.9% in HFpEF, p = 0.009) that was limited to patients undergoing ablation of the AV node.CONCLUSIONS: Catheter ablation strategies differ significantly in patients with HFpEF, HFmrEF, and HFrEF. In almost 50% of patients with HFrEF AV-node ablation was performed, going along with a significant increase in mortality rate. These results should raise efforts to further evaluate the prognostic effect of ablation strategies in HF patients.",
keywords = "Aged, Atrial Fibrillation/mortality, Atrioventricular Node/physiopathology, Catheter Ablation/standards, Female, Follow-Up Studies, Germany/epidemiology, Heart Failure/mortality, Humans, Male, Practice Guidelines as Topic, Prospective Studies, Registries, Stroke Volume/physiology, Survival Rate/trends, Treatment Outcome, Ventricular Function, Left/physiology",
author = "Charlotte Eitel and Hueseyin Ince and Johannes Brachmann and Karl-Heinz Kuck and Stephan Willems and Jin-Hong Gerds-Li and Juergen Tebbenjohanns and Gert Richardt and Matthias Hochadel and Jochen Senges and Tilz, {Roland R}",
year = "2019",
month = jul,
doi = "10.1007/s00392-019-01411-3",
language = "English",
volume = "108",
pages = "815--823",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "7",

}

RIS

TY - JOUR

T1 - Atrial fibrillation ablation strategies and outcome in patients with heart failure: insights from the German ablation registry

AU - Eitel, Charlotte

AU - Ince, Hueseyin

AU - Brachmann, Johannes

AU - Kuck, Karl-Heinz

AU - Willems, Stephan

AU - Gerds-Li, Jin-Hong

AU - Tebbenjohanns, Juergen

AU - Richardt, Gert

AU - Hochadel, Matthias

AU - Senges, Jochen

AU - Tilz, Roland R

PY - 2019/7

Y1 - 2019/7

N2 - BACKGROUND: Heart failure (HF) and atrial fibrillation (AF) often coexist, but data on the prognostic value of differing ablation strategies according to left ventricular ejection fraction (LVEF) are rare.METHODS AND RESULTS: From January 2007 until January 2010, 728 patients with HF were enrolled in the multi-center German ablation registry prior to AF catheter ablation. Patients were divided into three groups according to LVEF: HF with preserved LVEF (≥ 50%, HFpEF, n = 333), mid-range LVEF (40-49%, HFmrEF, n = 207), and reduced LVEF (< 40%, HFrEF, n = 188). Ablation strategies differed significantly between the three groups with the majority of patients with HFpEF (83.4%) and HFmrEF (78.4%) undergoing circumferential pulmonary vein isolation vs. 48.9% of patients with HFrEF. The latter underwent ablation of the atrioventricular (AV) node in 47.3%. Major complications did not differ between the groups. Kaplan-Meier survival analysis demonstrated a significant mortality increase in patients with HFrEF (6.1% in HFrEF vs. 1.5% in HFmrEF vs. 1.9% in HFpEF, p = 0.009) that was limited to patients undergoing ablation of the AV node.CONCLUSIONS: Catheter ablation strategies differ significantly in patients with HFpEF, HFmrEF, and HFrEF. In almost 50% of patients with HFrEF AV-node ablation was performed, going along with a significant increase in mortality rate. These results should raise efforts to further evaluate the prognostic effect of ablation strategies in HF patients.

AB - BACKGROUND: Heart failure (HF) and atrial fibrillation (AF) often coexist, but data on the prognostic value of differing ablation strategies according to left ventricular ejection fraction (LVEF) are rare.METHODS AND RESULTS: From January 2007 until January 2010, 728 patients with HF were enrolled in the multi-center German ablation registry prior to AF catheter ablation. Patients were divided into three groups according to LVEF: HF with preserved LVEF (≥ 50%, HFpEF, n = 333), mid-range LVEF (40-49%, HFmrEF, n = 207), and reduced LVEF (< 40%, HFrEF, n = 188). Ablation strategies differed significantly between the three groups with the majority of patients with HFpEF (83.4%) and HFmrEF (78.4%) undergoing circumferential pulmonary vein isolation vs. 48.9% of patients with HFrEF. The latter underwent ablation of the atrioventricular (AV) node in 47.3%. Major complications did not differ between the groups. Kaplan-Meier survival analysis demonstrated a significant mortality increase in patients with HFrEF (6.1% in HFrEF vs. 1.5% in HFmrEF vs. 1.9% in HFpEF, p = 0.009) that was limited to patients undergoing ablation of the AV node.CONCLUSIONS: Catheter ablation strategies differ significantly in patients with HFpEF, HFmrEF, and HFrEF. In almost 50% of patients with HFrEF AV-node ablation was performed, going along with a significant increase in mortality rate. These results should raise efforts to further evaluate the prognostic effect of ablation strategies in HF patients.

KW - Aged

KW - Atrial Fibrillation/mortality

KW - Atrioventricular Node/physiopathology

KW - Catheter Ablation/standards

KW - Female

KW - Follow-Up Studies

KW - Germany/epidemiology

KW - Heart Failure/mortality

KW - Humans

KW - Male

KW - Practice Guidelines as Topic

KW - Prospective Studies

KW - Registries

KW - Stroke Volume/physiology

KW - Survival Rate/trends

KW - Treatment Outcome

KW - Ventricular Function, Left/physiology

U2 - 10.1007/s00392-019-01411-3

DO - 10.1007/s00392-019-01411-3

M3 - SCORING: Journal article

C2 - 30788620

VL - 108

SP - 815

EP - 823

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 7

ER -