Atomic force microscopy as an innovative tool for nanoanalysis of native stratum corneum

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Atomic force microscopy as an innovative tool for nanoanalysis of native stratum corneum. / Gorzelanny, Christian; Goerge, Tobias; Schnaeker, Eva-Maria; Thomas, Kai; Luger, Thomas A; Schneider, Stefan W.

in: EXP DERMATOL, Jahrgang 15, Nr. 5, 05.2006, S. 387-91.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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Bibtex

@article{8042248393884520aabaca80a06f671e,
title = "Atomic force microscopy as an innovative tool for nanoanalysis of native stratum corneum",
abstract = "This study demonstrates an innovative application of atomic force microscopy (AFM). The combination of high-resolution AFM technology and tape stripping is presented as a tool for the structure analysis of human stratum corneum (SC) at a nanometer scale. Topographic images with a vertical resolution of about 10 nm of the SC are presented. Topographical and structural differences between aged and young skin can be observed. Aged skin SC is characterized by an increased single-cell surface area, prominent intercellular gaps and enhanced cell surface roughness. The use of AFM in combination with other already established methods, e.g. tape stripping in the field of dermatological research will give new insights to the structure, function and morphodynamics of SC.",
keywords = "Adult, Aged, Epidermis, Humans, Male, Microscopy, Atomic Force, Nanotechnology, Skin Aging, Specimen Handling, Journal Article, Research Support, Non-U.S. Gov't",
author = "Christian Gorzelanny and Tobias Goerge and Eva-Maria Schnaeker and Kai Thomas and Luger, {Thomas A} and Schneider, {Stefan W}",
year = "2006",
month = may,
doi = "10.1111/j.0906-6705.2006.00424.x",
language = "English",
volume = "15",
pages = "387--91",
journal = "EXP DERMATOL",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Atomic force microscopy as an innovative tool for nanoanalysis of native stratum corneum

AU - Gorzelanny, Christian

AU - Goerge, Tobias

AU - Schnaeker, Eva-Maria

AU - Thomas, Kai

AU - Luger, Thomas A

AU - Schneider, Stefan W

PY - 2006/5

Y1 - 2006/5

N2 - This study demonstrates an innovative application of atomic force microscopy (AFM). The combination of high-resolution AFM technology and tape stripping is presented as a tool for the structure analysis of human stratum corneum (SC) at a nanometer scale. Topographic images with a vertical resolution of about 10 nm of the SC are presented. Topographical and structural differences between aged and young skin can be observed. Aged skin SC is characterized by an increased single-cell surface area, prominent intercellular gaps and enhanced cell surface roughness. The use of AFM in combination with other already established methods, e.g. tape stripping in the field of dermatological research will give new insights to the structure, function and morphodynamics of SC.

AB - This study demonstrates an innovative application of atomic force microscopy (AFM). The combination of high-resolution AFM technology and tape stripping is presented as a tool for the structure analysis of human stratum corneum (SC) at a nanometer scale. Topographic images with a vertical resolution of about 10 nm of the SC are presented. Topographical and structural differences between aged and young skin can be observed. Aged skin SC is characterized by an increased single-cell surface area, prominent intercellular gaps and enhanced cell surface roughness. The use of AFM in combination with other already established methods, e.g. tape stripping in the field of dermatological research will give new insights to the structure, function and morphodynamics of SC.

KW - Adult

KW - Aged

KW - Epidermis

KW - Humans

KW - Male

KW - Microscopy, Atomic Force

KW - Nanotechnology

KW - Skin Aging

KW - Specimen Handling

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/j.0906-6705.2006.00424.x

DO - 10.1111/j.0906-6705.2006.00424.x

M3 - SCORING: Journal article

C2 - 16630080

VL - 15

SP - 387

EP - 391

JO - EXP DERMATOL

JF - EXP DERMATOL

SN - 0906-6705

IS - 5

ER -