Atomic force microscopy as an innovative tool for nanoanalysis of native stratum corneum
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Atomic force microscopy as an innovative tool for nanoanalysis of native stratum corneum. / Gorzelanny, Christian; Goerge, Tobias; Schnaeker, Eva-Maria; Thomas, Kai; Luger, Thomas A; Schneider, Stefan W.
in: EXP DERMATOL, Jahrgang 15, Nr. 5, 05.2006, S. 387-91.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Atomic force microscopy as an innovative tool for nanoanalysis of native stratum corneum
AU - Gorzelanny, Christian
AU - Goerge, Tobias
AU - Schnaeker, Eva-Maria
AU - Thomas, Kai
AU - Luger, Thomas A
AU - Schneider, Stefan W
PY - 2006/5
Y1 - 2006/5
N2 - This study demonstrates an innovative application of atomic force microscopy (AFM). The combination of high-resolution AFM technology and tape stripping is presented as a tool for the structure analysis of human stratum corneum (SC) at a nanometer scale. Topographic images with a vertical resolution of about 10 nm of the SC are presented. Topographical and structural differences between aged and young skin can be observed. Aged skin SC is characterized by an increased single-cell surface area, prominent intercellular gaps and enhanced cell surface roughness. The use of AFM in combination with other already established methods, e.g. tape stripping in the field of dermatological research will give new insights to the structure, function and morphodynamics of SC.
AB - This study demonstrates an innovative application of atomic force microscopy (AFM). The combination of high-resolution AFM technology and tape stripping is presented as a tool for the structure analysis of human stratum corneum (SC) at a nanometer scale. Topographic images with a vertical resolution of about 10 nm of the SC are presented. Topographical and structural differences between aged and young skin can be observed. Aged skin SC is characterized by an increased single-cell surface area, prominent intercellular gaps and enhanced cell surface roughness. The use of AFM in combination with other already established methods, e.g. tape stripping in the field of dermatological research will give new insights to the structure, function and morphodynamics of SC.
KW - Adult
KW - Aged
KW - Epidermis
KW - Humans
KW - Male
KW - Microscopy, Atomic Force
KW - Nanotechnology
KW - Skin Aging
KW - Specimen Handling
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1111/j.0906-6705.2006.00424.x
DO - 10.1111/j.0906-6705.2006.00424.x
M3 - SCORING: Journal article
C2 - 16630080
VL - 15
SP - 387
EP - 391
JO - EXP DERMATOL
JF - EXP DERMATOL
SN - 0906-6705
IS - 5
ER -