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Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease

Standard

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease. / Roe, James M; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M; Düzel, Sandra; Gonzalez, Hector A; Kievit, Rogier A; Knights, Ethan; Kühn, Simone; Lindenberger, Ulman; Mowinckel, Athanasia M; Nyberg, Lars; Park, Denise C; Pudas, Sara; Rundle, Melissa M; Walhovd, Kristine B; Fjell, Anders M; Westerhausen, René; Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing.

in: NAT COMMUN, Jahrgang 12, Nr. 1, 721, 01.02.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Roe, JM, Vidal-Piñeiro, D, Sørensen, Ø, Brandmaier, AM, Düzel, S, Gonzalez, HA, Kievit, RA, Knights, E, Kühn, S, Lindenberger, U, Mowinckel, AM, Nyberg, L, Park, DC, Pudas, S, Rundle, MM, Walhovd, KB, Fjell, AM, Westerhausen, R & Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing 2021, 'Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease', NAT COMMUN, Jg. 12, Nr. 1, 721. https://doi.org/10.1038/s41467-021-21057-y

APA

Roe, J. M., Vidal-Piñeiro, D., Sørensen, Ø., Brandmaier, A. M., Düzel, S., Gonzalez, H. A., Kievit, R. A., Knights, E., Kühn, S., Lindenberger, U., Mowinckel, A. M., Nyberg, L., Park, D. C., Pudas, S., Rundle, M. M., Walhovd, K. B., Fjell, A. M., Westerhausen, R., & Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing (2021). Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease. NAT COMMUN, 12(1), [721]. https://doi.org/10.1038/s41467-021-21057-y

Vancouver

Roe JM, Vidal-Piñeiro D, Sørensen Ø, Brandmaier AM, Düzel S, Gonzalez HA et al. Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease. NAT COMMUN. 2021 Feb 1;12(1). 721. https://doi.org/10.1038/s41467-021-21057-y

Bibtex

@article{9ca3edba92dc4eb18f72a517479e4b66,
title = "Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease",
abstract = "Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.",
keywords = "Adult, Aged, Aged, 80 and over, Aging/physiology, Alzheimer Disease/pathology, Cerebral Cortex/diagnostic imaging, Female, Healthy Volunteers, Humans, Longitudinal Studies, Magnetic Resonance Imaging/statistics & numerical data, Male, Middle Aged, Organ Size/physiology, Time Factors, Young Adult",
author = "Roe, {James M} and Didac Vidal-Pi{\~n}eiro and {\O}ystein S{\o}rensen and Brandmaier, {Andreas M} and Sandra D{\"u}zel and Gonzalez, {Hector A} and Kievit, {Rogier A} and Ethan Knights and Simone K{\"u}hn and Ulman Lindenberger and Mowinckel, {Athanasia M} and Lars Nyberg and Park, {Denise C} and Sara Pudas and Rundle, {Melissa M} and Walhovd, {Kristine B} and Fjell, {Anders M} and Ren{\'e} Westerhausen and {Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing}",
year = "2021",
month = feb,
day = "1",
doi = "10.1038/s41467-021-21057-y",
language = "English",
volume = "12",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease

AU - Roe, James M

AU - Vidal-Piñeiro, Didac

AU - Sørensen, Øystein

AU - Brandmaier, Andreas M

AU - Düzel, Sandra

AU - Gonzalez, Hector A

AU - Kievit, Rogier A

AU - Knights, Ethan

AU - Kühn, Simone

AU - Lindenberger, Ulman

AU - Mowinckel, Athanasia M

AU - Nyberg, Lars

AU - Park, Denise C

AU - Pudas, Sara

AU - Rundle, Melissa M

AU - Walhovd, Kristine B

AU - Fjell, Anders M

AU - Westerhausen, René

AU - Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing

PY - 2021/2/1

Y1 - 2021/2/1

N2 - Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.

AB - Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging/physiology

KW - Alzheimer Disease/pathology

KW - Cerebral Cortex/diagnostic imaging

KW - Female

KW - Healthy Volunteers

KW - Humans

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging/statistics & numerical data

KW - Male

KW - Middle Aged

KW - Organ Size/physiology

KW - Time Factors

KW - Young Adult

U2 - 10.1038/s41467-021-21057-y

DO - 10.1038/s41467-021-21057-y

M3 - SCORING: Journal article

C2 - 33526780

VL - 12

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

M1 - 721

ER -