Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study.
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Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study. / Schulze, Friedrich; Lenzen, Henrike; Hanefeld, Christoph; Bartling, Asja; Osterziel, Karl J; Goudeva, Lilia; Schmidt-Lucke, Caroline; Kusus, Magda; Maas, Renke; Schwedhelm, Edzard; Strödter, Dietrich; Simon, Bernd C; Mügge, Andreas; Daniel, Werner G; Tillmanns, Harald; Maisch, Bernhard; Streichert, Thomas; Böger, Rainer H.
in: AM HEART J, Jahrgang 152, Nr. 3, 3, 2006, S. 1-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study.
AU - Schulze, Friedrich
AU - Lenzen, Henrike
AU - Hanefeld, Christoph
AU - Bartling, Asja
AU - Osterziel, Karl J
AU - Goudeva, Lilia
AU - Schmidt-Lucke, Caroline
AU - Kusus, Magda
AU - Maas, Renke
AU - Schwedhelm, Edzard
AU - Strödter, Dietrich
AU - Simon, Bernd C
AU - Mügge, Andreas
AU - Daniel, Werner G
AU - Tillmanns, Harald
AU - Maisch, Bernhard
AU - Streichert, Thomas
AU - Böger, Rainer H
PY - 2006
Y1 - 2006
N2 - BACKGROUND: Asymmetric dimethylarginine (ADMA) plasma levels have been shown to be elevated in diseases related to endothelial dysfunction such as hypertension, hyperlipidemia, diabetes mellitus, and others. It has been shown that ADMA predicts cardiovascular mortality in patients who have coronary heart disease (CHD). However, the question whether ADMA is an independent risk factor for CHD still remains unresolved. METHODS: The CARDIAC study is a multicenter case-control study, designed to detect differences in ADMA plasma levels between patients with CHD and controls from the general population. We included in our analysis 131 cases and 131 controls, matched for age, sex, and body mass index. RESULTS: We found that cases had higher ADMA plasma levels than controls (0.70 micromol/L [0.59-0.87 micromol/L] vs 0.60 micromol/L [0.54-0.69 micromol/L], P <.001). To evaluate the predictive power of ADMA regarding CHD, we calculated 2 multivariate logistic regression models including laboratory parameters and traditional risk factors. The odds ratio for ADMA in the multivariate model including the laboratory characteristics was 2.59 (1.61-4.17; P <.001); the odds ratio for the multivariate model including other risk factors was 6.04 (2.56-14.25; P <.001) for the third tertile (>0.72 micromol/L) versus the first (
AB - BACKGROUND: Asymmetric dimethylarginine (ADMA) plasma levels have been shown to be elevated in diseases related to endothelial dysfunction such as hypertension, hyperlipidemia, diabetes mellitus, and others. It has been shown that ADMA predicts cardiovascular mortality in patients who have coronary heart disease (CHD). However, the question whether ADMA is an independent risk factor for CHD still remains unresolved. METHODS: The CARDIAC study is a multicenter case-control study, designed to detect differences in ADMA plasma levels between patients with CHD and controls from the general population. We included in our analysis 131 cases and 131 controls, matched for age, sex, and body mass index. RESULTS: We found that cases had higher ADMA plasma levels than controls (0.70 micromol/L [0.59-0.87 micromol/L] vs 0.60 micromol/L [0.54-0.69 micromol/L], P <.001). To evaluate the predictive power of ADMA regarding CHD, we calculated 2 multivariate logistic regression models including laboratory parameters and traditional risk factors. The odds ratio for ADMA in the multivariate model including the laboratory characteristics was 2.59 (1.61-4.17; P <.001); the odds ratio for the multivariate model including other risk factors was 6.04 (2.56-14.25; P <.001) for the third tertile (>0.72 micromol/L) versus the first (
M3 - SCORING: Zeitschriftenaufsatz
VL - 152
SP - 1
EP - 8
JO - AM HEART J
JF - AM HEART J
SN - 0002-8703
IS - 3
M1 - 3
ER -