Astrocyte-neuron interaction at tripartite synapses
Standard
Astrocyte-neuron interaction at tripartite synapses. / Araque, Alfonso; Perez-Alvarez, Alberto.
in: CURR DRUG TARGETS, Jahrgang 14, Nr. 11, 01.10.2013, S. 1220-1224.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Astrocyte-neuron interaction at tripartite synapses
AU - Araque, Alfonso
AU - Perez-Alvarez, Alberto
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Astrocytes, classically considered as supportive cells for neurons without a direct role in brain information processing, are emerging as relevant elements in brain physiology through their ability to regulate neuronal activity and synaptic transmission and plasticity. In relation to the key role of astrocyte-neuron interactions in synaptic physiology, accumulating evidence suggests that dysfunctions of neuron-astrocyte signaling may be linked to the pathology of various neurological and neurodegenerative diseases. In this article, we summarize the evidence supporting the importance of astrocyte-neuron communication in synaptic physiology, which have led to reveal astrocytes as integral elements of synaptic function. We also discuss how this novel view of astrocytic functions on brain physiology is prompting us to reconsider the possible astrocytic roles in brain diseases, and specifically in depression.
AB - Astrocytes, classically considered as supportive cells for neurons without a direct role in brain information processing, are emerging as relevant elements in brain physiology through their ability to regulate neuronal activity and synaptic transmission and plasticity. In relation to the key role of astrocyte-neuron interactions in synaptic physiology, accumulating evidence suggests that dysfunctions of neuron-astrocyte signaling may be linked to the pathology of various neurological and neurodegenerative diseases. In this article, we summarize the evidence supporting the importance of astrocyte-neuron communication in synaptic physiology, which have led to reveal astrocytes as integral elements of synaptic function. We also discuss how this novel view of astrocytic functions on brain physiology is prompting us to reconsider the possible astrocytic roles in brain diseases, and specifically in depression.
KW - Animals
KW - Astrocytes
KW - Brain
KW - Cell Communication
KW - Humans
KW - Mood Disorders
KW - Neurons
KW - Neurotransmitter Agents
KW - Synapses
KW - Synaptic Transmission
U2 - 10.2174/13894501113149990203
DO - 10.2174/13894501113149990203
M3 - SCORING: Journal article
C2 - 23621508
VL - 14
SP - 1220
EP - 1224
JO - CURR DRUG TARGETS
JF - CURR DRUG TARGETS
SN - 1389-4501
IS - 11
ER -