Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-Study

TY - JOUR

T1 - Associations of Depressive Symptoms with Subjective Cognitive Decline in Elderly People—A Cross-Sectional Analysis from the AgeWell.de-Study

AU - Zöllinger, Isabel

AU - Bauer, Alexander

AU - Blotenberg, Iris

AU - Brettschneider, Christian

AU - Buchholz, Maresa

AU - Czock, David

AU - Döhring, Juliane

AU - Escales, Catharina

AU - Fankhaenel, Thomas

AU - Frese, Thomas

AU - Hoffmann, Wolfgang

AU - Kaduszkiewicz, Hanna

AU - König, Hans-Helmut

AU - Luppa, Melanie

AU - Oey, Anke

AU - Pabst, Alexander

AU - Sanftenberg, Linda

AU - Thyrian, Jochen René

AU - Weiss, Julian

AU - Wendel, Flora

AU - Wiese, Birgitt

AU - Riedel-Heller, Steffi G.

AU - Gensichen, Jochen

PY - 2023/8/10

Y1 - 2023/8/10

N2 - To develop effective dementia prevention strategies, it is necessary to understand risk factors, associated factors and early signs of dementia. Subjective cognitive decline (SCD) is the earliest form of dementia. The aim of this study is to assess depression as a factor that is significantly associated with SCD. The data of 1030 general practitioner patients from the AgeWell.de-study (60-77 years; CAIDE dementia risk score ≥ 9) were analysed. A descriptive analysis was conducted using validated instruments like the Geriatric depression scale (GDS), Lubben social network scale (LSNS-6) and education classes according to CASMIN (Comparative Analysis of Social Mobility in Industrial Nations). A multivariate regression model with the dependent variable SCD was calculated. Of the 1030 participants, 5.9% had depressive symptoms and 31.3% SCD. The group with depressive symptoms showed significantly higher body-mass-index (p = 0.005), lower education class (p = 0.022), lower LSNS-6 score (p < 0.001), higher sports activity (p < 0.001), and more sleeping problems (p = 0.026). In the regression model a higher GDS-score [Odds ratio (OR): 1.219 (p < 0.001)], more sleeping problems [OR: 1.550 (p = 0.017)] and higher education class [middle/high: OR: 1.474/1.875 (p = 0.037/0.004)] were significantly associated with SCD. This study identified depressive symptoms, sleeping problems, and higher education classes as factors associated with SCD, which can represent an early form of dementia.

AB - To develop effective dementia prevention strategies, it is necessary to understand risk factors, associated factors and early signs of dementia. Subjective cognitive decline (SCD) is the earliest form of dementia. The aim of this study is to assess depression as a factor that is significantly associated with SCD. The data of 1030 general practitioner patients from the AgeWell.de-study (60-77 years; CAIDE dementia risk score ≥ 9) were analysed. A descriptive analysis was conducted using validated instruments like the Geriatric depression scale (GDS), Lubben social network scale (LSNS-6) and education classes according to CASMIN (Comparative Analysis of Social Mobility in Industrial Nations). A multivariate regression model with the dependent variable SCD was calculated. Of the 1030 participants, 5.9% had depressive symptoms and 31.3% SCD. The group with depressive symptoms showed significantly higher body-mass-index (p = 0.005), lower education class (p = 0.022), lower LSNS-6 score (p < 0.001), higher sports activity (p < 0.001), and more sleeping problems (p = 0.026). In the regression model a higher GDS-score [Odds ratio (OR): 1.219 (p < 0.001)], more sleeping problems [OR: 1.550 (p = 0.017)] and higher education class [middle/high: OR: 1.474/1.875 (p = 0.037/0.004)] were significantly associated with SCD. This study identified depressive symptoms, sleeping problems, and higher education classes as factors associated with SCD, which can represent an early form of dementia.

U2 - 10.3390/jcm12165205

DO - 10.3390/jcm12165205

M3 - SCORING: Journal article

VL - 12

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 16

M1 - 5205

ER -