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Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype

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Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype. / Cascalheira, José F; Gonçalves, Mónica; Barroso, Madalena; Castro, Rita; Palmeira, Manuela; Serpa, André; Dias-Cabral, Ana C; Domingues, Fernanda C; Almeida, Sofia.

in: ANN CLIN BIOCHEM, Jahrgang 52, Nr. Pt 4, 07.2015, S. 448-55.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Cascalheira, JF, Gonçalves, M, Barroso, M, Castro, R, Palmeira, M, Serpa, A, Dias-Cabral, AC, Domingues, FC & Almeida, S 2015, 'Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype', ANN CLIN BIOCHEM, Jg. 52, Nr. Pt 4, S. 448-55. https://doi.org/10.1177/0004563214561770

APA

Cascalheira, J. F., Gonçalves, M., Barroso, M., Castro, R., Palmeira, M., Serpa, A., Dias-Cabral, A. C., Domingues, F. C., & Almeida, S. (2015). Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype. ANN CLIN BIOCHEM, 52(Pt 4), 448-55. https://doi.org/10.1177/0004563214561770

Vancouver

Cascalheira JF, Gonçalves M, Barroso M, Castro R, Palmeira M, Serpa A et al. Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype. ANN CLIN BIOCHEM. 2015 Jul;52(Pt 4):448-55. https://doi.org/10.1177/0004563214561770

Bibtex

@article{07026fae4a3e4aa0a30f11781c30e142,
title = "Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype",
abstract = "BACKGROUND: Decreased serum concentrations of vitamin B12 are associated with Alzheimer's type dementia. The transcobalamin II gene (TCN2) 776C → G polymorphism affects transcobalamin II function as a carrier of vitamin B12 and might modify its availability. The association of the TCN2 776C → G polymorphism with Alzheimer's type dementia is unclear and was investigated in the present study.METHODS: Case-control study including 27 individuals diagnosed with Alzheimer's type dementia and 28 healthy controls. Serum concentrations of vitamin B12, homocysteine and other analytes were determined and the presence of TCN2 776C → G and 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphisms genotypes was ascertained by polymerase chain reaction-restriction fragment length polymorphism.RESULTS: Serum concentrations of vitamin B12 were lower while those of homocysteine were higher in patients than in controls (P < 0.05). The frequency of individuals carrying at least one 5, 10-methylenetetrahydrofolate reductase 1298C allele was higher (59% versus 32%) while frequency of individuals harbouring at least one TCN2 776G allele was lower (58% versus 86%) in patients than in controls (P < 0.05). Univariate logistic regression showed negative association of TCN2 776CG genotype with Alzheimer's type dementia (OR = 0.17 versus CC genotype, P < 0.02). Multivariate logistic regression identified TCN2 776C → G polymorphism as independent predictor of Alzheimer's type dementia together with higher concentrations of homocysteine, cholesterol and uric acid and lower concentrations of oestradiol. Association of TCN2 776C → G polymorphism with Alzheimer's type dementia was observed for individuals carrying the 5,10-methylenetetrahydrofolate reductase 1298AA genotype but not the AC or CC genotypes, indicating interaction between the two polymorphisms.CONCLUSIONS: The TCN2 776C → G polymorphism is negatively associated with Alzheimer's type dementia, suggesting a protective role against the disease in subjects with the 5, 10-methylenetetrahydrofolate reductase 1298AA genotype.",
keywords = "Aged, Alleles, Alzheimer Disease, Biomarkers, Case-Control Studies, Female, Gene Frequency, Genotype, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2), Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Prognosis, Tetrahydrofolates, Transcobalamins, Vitamin B 12, Journal Article, Research Support, Non-U.S. Gov't",
author = "Cascalheira, {Jos{\'e} F} and M{\'o}nica Gon{\c c}alves and Madalena Barroso and Rita Castro and Manuela Palmeira and Andr{\'e} Serpa and Dias-Cabral, {Ana C} and Domingues, {Fernanda C} and Sofia Almeida",
note = "{\textcopyright} The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.",
year = "2015",
month = jul,
doi = "10.1177/0004563214561770",
language = "English",
volume = "52",
pages = "448--55",
journal = "ANN CLIN BIOCHEM",
issn = "0004-5632",
publisher = "SAGE Publications",
number = "Pt 4",

}

RIS

TY - JOUR

T1 - Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype

AU - Cascalheira, José F

AU - Gonçalves, Mónica

AU - Barroso, Madalena

AU - Castro, Rita

AU - Palmeira, Manuela

AU - Serpa, André

AU - Dias-Cabral, Ana C

AU - Domingues, Fernanda C

AU - Almeida, Sofia

N1 - © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

PY - 2015/7

Y1 - 2015/7

N2 - BACKGROUND: Decreased serum concentrations of vitamin B12 are associated with Alzheimer's type dementia. The transcobalamin II gene (TCN2) 776C → G polymorphism affects transcobalamin II function as a carrier of vitamin B12 and might modify its availability. The association of the TCN2 776C → G polymorphism with Alzheimer's type dementia is unclear and was investigated in the present study.METHODS: Case-control study including 27 individuals diagnosed with Alzheimer's type dementia and 28 healthy controls. Serum concentrations of vitamin B12, homocysteine and other analytes were determined and the presence of TCN2 776C → G and 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphisms genotypes was ascertained by polymerase chain reaction-restriction fragment length polymorphism.RESULTS: Serum concentrations of vitamin B12 were lower while those of homocysteine were higher in patients than in controls (P < 0.05). The frequency of individuals carrying at least one 5, 10-methylenetetrahydrofolate reductase 1298C allele was higher (59% versus 32%) while frequency of individuals harbouring at least one TCN2 776G allele was lower (58% versus 86%) in patients than in controls (P < 0.05). Univariate logistic regression showed negative association of TCN2 776CG genotype with Alzheimer's type dementia (OR = 0.17 versus CC genotype, P < 0.02). Multivariate logistic regression identified TCN2 776C → G polymorphism as independent predictor of Alzheimer's type dementia together with higher concentrations of homocysteine, cholesterol and uric acid and lower concentrations of oestradiol. Association of TCN2 776C → G polymorphism with Alzheimer's type dementia was observed for individuals carrying the 5,10-methylenetetrahydrofolate reductase 1298AA genotype but not the AC or CC genotypes, indicating interaction between the two polymorphisms.CONCLUSIONS: The TCN2 776C → G polymorphism is negatively associated with Alzheimer's type dementia, suggesting a protective role against the disease in subjects with the 5, 10-methylenetetrahydrofolate reductase 1298AA genotype.

AB - BACKGROUND: Decreased serum concentrations of vitamin B12 are associated with Alzheimer's type dementia. The transcobalamin II gene (TCN2) 776C → G polymorphism affects transcobalamin II function as a carrier of vitamin B12 and might modify its availability. The association of the TCN2 776C → G polymorphism with Alzheimer's type dementia is unclear and was investigated in the present study.METHODS: Case-control study including 27 individuals diagnosed with Alzheimer's type dementia and 28 healthy controls. Serum concentrations of vitamin B12, homocysteine and other analytes were determined and the presence of TCN2 776C → G and 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphisms genotypes was ascertained by polymerase chain reaction-restriction fragment length polymorphism.RESULTS: Serum concentrations of vitamin B12 were lower while those of homocysteine were higher in patients than in controls (P < 0.05). The frequency of individuals carrying at least one 5, 10-methylenetetrahydrofolate reductase 1298C allele was higher (59% versus 32%) while frequency of individuals harbouring at least one TCN2 776G allele was lower (58% versus 86%) in patients than in controls (P < 0.05). Univariate logistic regression showed negative association of TCN2 776CG genotype with Alzheimer's type dementia (OR = 0.17 versus CC genotype, P < 0.02). Multivariate logistic regression identified TCN2 776C → G polymorphism as independent predictor of Alzheimer's type dementia together with higher concentrations of homocysteine, cholesterol and uric acid and lower concentrations of oestradiol. Association of TCN2 776C → G polymorphism with Alzheimer's type dementia was observed for individuals carrying the 5,10-methylenetetrahydrofolate reductase 1298AA genotype but not the AC or CC genotypes, indicating interaction between the two polymorphisms.CONCLUSIONS: The TCN2 776C → G polymorphism is negatively associated with Alzheimer's type dementia, suggesting a protective role against the disease in subjects with the 5, 10-methylenetetrahydrofolate reductase 1298AA genotype.

KW - Aged

KW - Alleles

KW - Alzheimer Disease

KW - Biomarkers

KW - Case-Control Studies

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Male

KW - Methylenetetrahydrofolate Reductase (NADPH2)

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Prognosis

KW - Tetrahydrofolates

KW - Transcobalamins

KW - Vitamin B 12

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1177/0004563214561770

DO - 10.1177/0004563214561770

M3 - SCORING: Journal article

C2 - 25395544

VL - 52

SP - 448

EP - 455

JO - ANN CLIN BIOCHEM

JF - ANN CLIN BIOCHEM

SN - 0004-5632

IS - Pt 4

ER -