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Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women.

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Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women. / Aberle, Jens; Hopfer, Inga; Beil, Frank Ulrich; Seedorf, Udo.

in: INT J MED SCI, Jahrgang 3, Nr. 3, 3, 2006, S. 108-111.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Aberle, J, Hopfer, I, Beil, FU & Seedorf, U 2006, 'Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women.', INT J MED SCI, Jg. 3, Nr. 3, 3, S. 108-111. https://doi.org/10.7150/ijms.3.108

APA

Aberle, J., Hopfer, I., Beil, F. U., & Seedorf, U. (2006). Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women. INT J MED SCI, 3(3), 108-111. [3]. https://doi.org/10.7150/ijms.3.108

Vancouver

Aberle J, Hopfer I, Beil FU, Seedorf U. Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women. INT J MED SCI. 2006;3(3):108-111. 3. https://doi.org/10.7150/ijms.3.108

Bibtex

@article{38631668c4f8401f8d9281673eb9d1c0,
title = "Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women.",
abstract = "BACKGROUND: The +T294C polymorphism in PPARdelta represents a functional SNP affecting transcriptional activity of the PPARdelta gene. To address whether this polymorphism is associated with the risk for coronary heart disease and/or plasma lipid levels in women, we studied a group of 967 female patients with hyperlipidaemia in the presence (n=453) or absence (n=514) of coronary heart disease. METHODS: 967 female patients with or without coronary heart disease were genotyped using mutagenically separated polymerase chain reaction (MS-PCR). Statistical analysis was performed according to genotype with parameters of lipid metabolism as dependant variables. RESULTS: A highly significant association between the rare C allele and lower plasma HDL concentrations was found in female subjects. The effect remained significant after correcting for multiparametric testing according to Bonferoni and was seen only in subjects with a BMI below the median. Moreover, a significant association of the C-allele with coronary heart disease and BMI was obtained. Regarding the entire group, trends towards higher VLDL and LDL levels were observed. CONCLUSIONS: Our data show for the first time that the PPARdelta +T294C polymorphism is associated with lipid levels and coronary heart disease in women. However, the molecular mechanism of action remains to be elucidated.",
author = "Jens Aberle and Inga Hopfer and Beil, {Frank Ulrich} and Udo Seedorf",
year = "2006",
doi = "10.7150/ijms.3.108",
language = "Deutsch",
volume = "3",
pages = "108--111",
number = "3",

}

RIS

TY - JOUR

T1 - Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women.

AU - Aberle, Jens

AU - Hopfer, Inga

AU - Beil, Frank Ulrich

AU - Seedorf, Udo

PY - 2006

Y1 - 2006

N2 - BACKGROUND: The +T294C polymorphism in PPARdelta represents a functional SNP affecting transcriptional activity of the PPARdelta gene. To address whether this polymorphism is associated with the risk for coronary heart disease and/or plasma lipid levels in women, we studied a group of 967 female patients with hyperlipidaemia in the presence (n=453) or absence (n=514) of coronary heart disease. METHODS: 967 female patients with or without coronary heart disease were genotyped using mutagenically separated polymerase chain reaction (MS-PCR). Statistical analysis was performed according to genotype with parameters of lipid metabolism as dependant variables. RESULTS: A highly significant association between the rare C allele and lower plasma HDL concentrations was found in female subjects. The effect remained significant after correcting for multiparametric testing according to Bonferoni and was seen only in subjects with a BMI below the median. Moreover, a significant association of the C-allele with coronary heart disease and BMI was obtained. Regarding the entire group, trends towards higher VLDL and LDL levels were observed. CONCLUSIONS: Our data show for the first time that the PPARdelta +T294C polymorphism is associated with lipid levels and coronary heart disease in women. However, the molecular mechanism of action remains to be elucidated.

AB - BACKGROUND: The +T294C polymorphism in PPARdelta represents a functional SNP affecting transcriptional activity of the PPARdelta gene. To address whether this polymorphism is associated with the risk for coronary heart disease and/or plasma lipid levels in women, we studied a group of 967 female patients with hyperlipidaemia in the presence (n=453) or absence (n=514) of coronary heart disease. METHODS: 967 female patients with or without coronary heart disease were genotyped using mutagenically separated polymerase chain reaction (MS-PCR). Statistical analysis was performed according to genotype with parameters of lipid metabolism as dependant variables. RESULTS: A highly significant association between the rare C allele and lower plasma HDL concentrations was found in female subjects. The effect remained significant after correcting for multiparametric testing according to Bonferoni and was seen only in subjects with a BMI below the median. Moreover, a significant association of the C-allele with coronary heart disease and BMI was obtained. Regarding the entire group, trends towards higher VLDL and LDL levels were observed. CONCLUSIONS: Our data show for the first time that the PPARdelta +T294C polymorphism is associated with lipid levels and coronary heart disease in women. However, the molecular mechanism of action remains to be elucidated.

U2 - 10.7150/ijms.3.108

DO - 10.7150/ijms.3.108

M3 - SCORING: Zeitschriftenaufsatz

VL - 3

SP - 108

EP - 111

IS - 3

M1 - 3

ER -