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Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.

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Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration. / Schürmann, Britta; Wiese, Birgitt; Bickel, Horst; Weyerer, Siegfried; Riedel-Heller, Steffi G; Pentzek, Michael; Bachmann, Cadja; Williams, Julie; Bussche van den, Hendrik; Maier, Wolfgang; Jessen, Frank.

in: J ALZHEIMERS DIS, Jahrgang 25, Nr. 3, 3, 2011, S. 421-424.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schürmann, B, Wiese, B, Bickel, H, Weyerer, S, Riedel-Heller, SG, Pentzek, M, Bachmann, C, Williams, J, Bussche van den, H, Maier, W & Jessen, F 2011, 'Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.', J ALZHEIMERS DIS, Jg. 25, Nr. 3, 3, S. 421-424. <http://www.ncbi.nlm.nih.gov/pubmed/21422520?dopt=Citation>

APA

Schürmann, B., Wiese, B., Bickel, H., Weyerer, S., Riedel-Heller, S. G., Pentzek, M., Bachmann, C., Williams, J., Bussche van den, H., Maier, W., & Jessen, F. (2011). Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration. J ALZHEIMERS DIS, 25(3), 421-424. [3]. http://www.ncbi.nlm.nih.gov/pubmed/21422520?dopt=Citation

Vancouver

Schürmann B, Wiese B, Bickel H, Weyerer S, Riedel-Heller SG, Pentzek M et al. Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration. J ALZHEIMERS DIS. 2011;25(3):421-424. 3.

Bibtex

@article{68d7679020ca40388ba7c405127ff6c2,
title = "Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.",
abstract = "A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels.",
keywords = "Humans, Male, Female, Aged, 80 and over, Risk Factors, Longitudinal Studies, Enzyme-Linked Immunosorbent Assay, Analysis of Variance, Alzheimer Disease/*blood/*genetics, Clusterin/*blood/*genetics, Genetic Predisposition to Disease/*genetics, Genetic Variation/*genetics, Genome-Wide Association Study/methods, Humans, Male, Female, Aged, 80 and over, Risk Factors, Longitudinal Studies, Enzyme-Linked Immunosorbent Assay, Analysis of Variance, Alzheimer Disease/*blood/*genetics, Clusterin/*blood/*genetics, Genetic Predisposition to Disease/*genetics, Genetic Variation/*genetics, Genome-Wide Association Study/methods",
author = "Britta Sch{\"u}rmann and Birgitt Wiese and Horst Bickel and Siegfried Weyerer and Riedel-Heller, {Steffi G} and Michael Pentzek and Cadja Bachmann and Julie Williams and {Bussche van den}, Hendrik and Wolfgang Maier and Frank Jessen",
year = "2011",
language = "English",
volume = "25",
pages = "421--424",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "3",

}

RIS

TY - JOUR

T1 - Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.

AU - Schürmann, Britta

AU - Wiese, Birgitt

AU - Bickel, Horst

AU - Weyerer, Siegfried

AU - Riedel-Heller, Steffi G

AU - Pentzek, Michael

AU - Bachmann, Cadja

AU - Williams, Julie

AU - Bussche van den, Hendrik

AU - Maier, Wolfgang

AU - Jessen, Frank

PY - 2011

Y1 - 2011

N2 - A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels.

AB - A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels.

KW - Humans

KW - Male

KW - Female

KW - Aged, 80 and over

KW - Risk Factors

KW - Longitudinal Studies

KW - Enzyme-Linked Immunosorbent Assay

KW - Analysis of Variance

KW - Alzheimer Disease/blood/genetics

KW - Clusterin/blood/genetics

KW - Genetic Predisposition to Disease/genetics

KW - Genetic Variation/genetics

KW - Genome-Wide Association Study/methods

KW - Humans

KW - Male

KW - Female

KW - Aged, 80 and over

KW - Risk Factors

KW - Longitudinal Studies

KW - Enzyme-Linked Immunosorbent Assay

KW - Analysis of Variance

KW - Alzheimer Disease/blood/genetics

KW - Clusterin/blood/genetics

KW - Genetic Predisposition to Disease/genetics

KW - Genetic Variation/genetics

KW - Genome-Wide Association Study/methods

M3 - SCORING: Journal article

VL - 25

SP - 421

EP - 424

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 3

M1 - 3

ER -