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Association of stroke lesion shape with newly detected atrial fibrillation – Results from the MonDAFIS study

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Association of stroke lesion shape with newly detected atrial fibrillation – Results from the MonDAFIS study. / Pimentel, Bernardo Crespo; Ingwersen, Thies; Haeusler, Karl Georg; Schlemm, Eckhard; Forkert, Nils D; Rajashekar, Deepthi; Mouches, Pauline; Königsberg, Alina; Kirchhof, Paulus; Kunze, Claudia; Tütüncü, Serdar; Olma, Manuel C; Krämer, Michael; Michalski, Dominik; Kraft, Andrea; Rizos, Timolaos; Helberg, Torsten; Ehrlich, Sven; Nabavi, Darius G; Röther, Joachim; Laufs, Ulrich; Veltkamp, Roland; Heuschmann, Peter U; Cheng, Bastian; Endres, Matthias; Thomalla, Götz.

in: EUR STROKE J, Jahrgang 7, Nr. 3, 25.05.2022, S. 230-237.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Pimentel, BC, Ingwersen, T, Haeusler, KG, Schlemm, E, Forkert, ND, Rajashekar, D, Mouches, P, Königsberg, A, Kirchhof, P, Kunze, C, Tütüncü, S, Olma, MC, Krämer, M, Michalski, D, Kraft, A, Rizos, T, Helberg, T, Ehrlich, S, Nabavi, DG, Röther, J, Laufs, U, Veltkamp, R, Heuschmann, PU, Cheng, B, Endres, M & Thomalla, G 2022, 'Association of stroke lesion shape with newly detected atrial fibrillation – Results from the MonDAFIS study', EUR STROKE J, Jg. 7, Nr. 3, S. 230-237. https://doi.org/10.1177/23969873221100895

APA

Pimentel, B. C., Ingwersen, T., Haeusler, K. G., Schlemm, E., Forkert, N. D., Rajashekar, D., Mouches, P., Königsberg, A., Kirchhof, P., Kunze, C., Tütüncü, S., Olma, M. C., Krämer, M., Michalski, D., Kraft, A., Rizos, T., Helberg, T., Ehrlich, S., Nabavi, D. G., ... Thomalla, G. (2022). Association of stroke lesion shape with newly detected atrial fibrillation – Results from the MonDAFIS study. EUR STROKE J, 7(3), 230-237. https://doi.org/10.1177/23969873221100895

Vancouver

Pimentel BC, Ingwersen T, Haeusler KG, Schlemm E, Forkert ND, Rajashekar D et al. Association of stroke lesion shape with newly detected atrial fibrillation – Results from the MonDAFIS study. EUR STROKE J. 2022 Mai 25;7(3):230-237. https://doi.org/10.1177/23969873221100895

Bibtex

@article{28fa00b577d74a239ad7ccb7d5091c66,
title = "Association of stroke lesion shape with newly detected atrial fibrillation – Results from the MonDAFIS study",
abstract = "Paroxysmal Atrial fibrillation (AF) is often clinically silent and may be missed by the usual diagnostic workup after ischemic stroke. We aimed to determine whether shape characteristics of ischemic stroke lesions can be used to predict AF in stroke patients without known AF at baseline. Lesion shape quantification on brain MRI was performed in selected patients from the intervention arm of the Impact of standardized MONitoring for Detection of Atrial Fibrillation in Ischemic Stroke (MonDAFIS) study, which included patients with ischemic stroke or TIA without prior AF. Multiple morphologic parameters were calculated based on lesion segmentation in acute brain MRI data. Multivariate logistic models were used to test the association of lesion morphology, clinical parameters, and AF. A stepwise elimination regression was conducted to identify the most important variables. A total of 755 patients were included. Patients with AF detected within 2 years after stroke (n = 86) had a larger overall oriented bounding box (OBB) volume (p = 0.003) and a higher number of brain lesion components (p = 0.008) than patients without AF. In the multivariate model, OBB volume (OR 1.72, 95%CI 1.29-2.35, p < 0.001), age (OR 2.13, 95%CI 1.52-3.06, p < 0.001), and female sex (OR 2.45, 95%CI 1.41-4.31, p = 0.002) were independently associated with detected AF. Ischemic lesions in patients with detected AF after stroke presented with a more dispersed infarct pattern and a higher number of lesion components. Together with clinical characteristics, these lesion shape characteristics may help in guiding prolonged cardiac monitoring after stroke.",
author = "Pimentel, {Bernardo Crespo} and Thies Ingwersen and Haeusler, {Karl Georg} and Eckhard Schlemm and Forkert, {Nils D} and Deepthi Rajashekar and Pauline Mouches and Alina K{\"o}nigsberg and Paulus Kirchhof and Claudia Kunze and Serdar T{\"u}t{\"u}nc{\"u} and Olma, {Manuel C} and Michael Kr{\"a}mer and Dominik Michalski and Andrea Kraft and Timolaos Rizos and Torsten Helberg and Sven Ehrlich and Nabavi, {Darius G} and Joachim R{\"o}ther and Ulrich Laufs and Roland Veltkamp and Heuschmann, {Peter U} and Bastian Cheng and Matthias Endres and G{\"o}tz Thomalla",
note = "{\textcopyright} European Stroke Organisation 2022.",
year = "2022",
month = may,
day = "25",
doi = "10.1177/23969873221100895",
language = "English",
volume = "7",
pages = "230--237",
journal = "EUR STROKE J",
issn = "2396-9873",
publisher = "SAGE Publications",
number = "3",

}

RIS

TY - JOUR

T1 - Association of stroke lesion shape with newly detected atrial fibrillation – Results from the MonDAFIS study

AU - Pimentel, Bernardo Crespo

AU - Ingwersen, Thies

AU - Haeusler, Karl Georg

AU - Schlemm, Eckhard

AU - Forkert, Nils D

AU - Rajashekar, Deepthi

AU - Mouches, Pauline

AU - Königsberg, Alina

AU - Kirchhof, Paulus

AU - Kunze, Claudia

AU - Tütüncü, Serdar

AU - Olma, Manuel C

AU - Krämer, Michael

AU - Michalski, Dominik

AU - Kraft, Andrea

AU - Rizos, Timolaos

AU - Helberg, Torsten

AU - Ehrlich, Sven

AU - Nabavi, Darius G

AU - Röther, Joachim

AU - Laufs, Ulrich

AU - Veltkamp, Roland

AU - Heuschmann, Peter U

AU - Cheng, Bastian

AU - Endres, Matthias

AU - Thomalla, Götz

N1 - © European Stroke Organisation 2022.

PY - 2022/5/25

Y1 - 2022/5/25

N2 - Paroxysmal Atrial fibrillation (AF) is often clinically silent and may be missed by the usual diagnostic workup after ischemic stroke. We aimed to determine whether shape characteristics of ischemic stroke lesions can be used to predict AF in stroke patients without known AF at baseline. Lesion shape quantification on brain MRI was performed in selected patients from the intervention arm of the Impact of standardized MONitoring for Detection of Atrial Fibrillation in Ischemic Stroke (MonDAFIS) study, which included patients with ischemic stroke or TIA without prior AF. Multiple morphologic parameters were calculated based on lesion segmentation in acute brain MRI data. Multivariate logistic models were used to test the association of lesion morphology, clinical parameters, and AF. A stepwise elimination regression was conducted to identify the most important variables. A total of 755 patients were included. Patients with AF detected within 2 years after stroke (n = 86) had a larger overall oriented bounding box (OBB) volume (p = 0.003) and a higher number of brain lesion components (p = 0.008) than patients without AF. In the multivariate model, OBB volume (OR 1.72, 95%CI 1.29-2.35, p < 0.001), age (OR 2.13, 95%CI 1.52-3.06, p < 0.001), and female sex (OR 2.45, 95%CI 1.41-4.31, p = 0.002) were independently associated with detected AF. Ischemic lesions in patients with detected AF after stroke presented with a more dispersed infarct pattern and a higher number of lesion components. Together with clinical characteristics, these lesion shape characteristics may help in guiding prolonged cardiac monitoring after stroke.

AB - Paroxysmal Atrial fibrillation (AF) is often clinically silent and may be missed by the usual diagnostic workup after ischemic stroke. We aimed to determine whether shape characteristics of ischemic stroke lesions can be used to predict AF in stroke patients without known AF at baseline. Lesion shape quantification on brain MRI was performed in selected patients from the intervention arm of the Impact of standardized MONitoring for Detection of Atrial Fibrillation in Ischemic Stroke (MonDAFIS) study, which included patients with ischemic stroke or TIA without prior AF. Multiple morphologic parameters were calculated based on lesion segmentation in acute brain MRI data. Multivariate logistic models were used to test the association of lesion morphology, clinical parameters, and AF. A stepwise elimination regression was conducted to identify the most important variables. A total of 755 patients were included. Patients with AF detected within 2 years after stroke (n = 86) had a larger overall oriented bounding box (OBB) volume (p = 0.003) and a higher number of brain lesion components (p = 0.008) than patients without AF. In the multivariate model, OBB volume (OR 1.72, 95%CI 1.29-2.35, p < 0.001), age (OR 2.13, 95%CI 1.52-3.06, p < 0.001), and female sex (OR 2.45, 95%CI 1.41-4.31, p = 0.002) were independently associated with detected AF. Ischemic lesions in patients with detected AF after stroke presented with a more dispersed infarct pattern and a higher number of lesion components. Together with clinical characteristics, these lesion shape characteristics may help in guiding prolonged cardiac monitoring after stroke.

U2 - 10.1177/23969873221100895

DO - 10.1177/23969873221100895

M3 - SCORING: Journal article

C2 - 36082264

VL - 7

SP - 230

EP - 237

JO - EUR STROKE J

JF - EUR STROKE J

SN - 2396-9873

IS - 3

ER -