PortalPublikationenAssociation of SORL1 gene variants with Alzheimer's disease.

Association of SORL1 gene variants with Alzheimer's disease.

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Association of SORL1 gene variants with Alzheimer's disease. / Kölsch, Heike; Jessen, Frank; Wiltfang, Jens; Lewczuk, Piotr; Dichgans, Martin; Teipel, Stefan J; Kornhuber, Johannes; Frölich, Lutz; Heuser, Isabella; Peters, Oliver; Wiese, Birgitt; Kaduszkiewicz, Hanna; Bussche van den, Hendrik; Hüll, Michael; Kurz, Alexander; Rüther, Eckhart; Henn, Fritz A; Maier, Wolfgang.

in: BRAIN RES, Jahrgang 1264, 2009, S. 1-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kölsch, H, Jessen, F, Wiltfang, J, Lewczuk, P, Dichgans, M, Teipel, SJ, Kornhuber, J, Frölich, L, Heuser, I, Peters, O, Wiese, B, Kaduszkiewicz, H, Bussche van den, H, Hüll, M, Kurz, A, Rüther, E, Henn, FA & Maier, W 2009, 'Association of SORL1 gene variants with Alzheimer's disease.', BRAIN RES, Jg. 1264, S. 1-6. <http://www.ncbi.nlm.nih.gov/pubmed/19368828?dopt=Citation>

APA

Kölsch, H., Jessen, F., Wiltfang, J., Lewczuk, P., Dichgans, M., Teipel, S. J., Kornhuber, J., Frölich, L., Heuser, I., Peters, O., Wiese, B., Kaduszkiewicz, H., Bussche van den, H., Hüll, M., Kurz, A., Rüther, E., Henn, F. A., & Maier, W. (2009). Association of SORL1 gene variants with Alzheimer's disease. BRAIN RES, 1264, 1-6. http://www.ncbi.nlm.nih.gov/pubmed/19368828?dopt=Citation

Vancouver

Kölsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Teipel SJ et al. Association of SORL1 gene variants with Alzheimer's disease. BRAIN RES. 2009;1264:1-6.

Bibtex

@article{c9229ec4ce3c4346baab501751434e6c,
title = "Association of SORL1 gene variants with Alzheimer's disease.",
abstract = "SORL1 gene variants were described as risk factor of Alzheimer's disease (AD) additionally SORL1 gene variants were associated with altered Abeta(42) CSF levels in AD patients. In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias. The SNP21G-allele and a SORL1 haplotype consisting of the SNP19 T-allele, SNP21 G-allele and SNP23 A-allele (T/G/A) were associated with increased hazard ratios and an earlier age at onset of AD (SNP21: p=0.002; T/G/A haplotype: p=0.007). This effect was most pronounced in carriers of an additional APOE4 allele (SNP21: p=0.003; T/G/A haplotype: p=0.005). In conclusion, we found SORL1 gene variants located in the 3' region of the gene to be associated with increased AD risk and an earlier age at onset of AD in our Central-European population. Thus, our data support a role of SORL1 polymorphisms in AD.",
author = "Heike K{\"o}lsch and Frank Jessen and Jens Wiltfang and Piotr Lewczuk and Martin Dichgans and Teipel, {Stefan J} and Johannes Kornhuber and Lutz Fr{\"o}lich and Isabella Heuser and Oliver Peters and Birgitt Wiese and Hanna Kaduszkiewicz and {Bussche van den}, Hendrik and Michael H{\"u}ll and Alexander Kurz and Eckhart R{\"u}ther and Henn, {Fritz A} and Wolfgang Maier",
year = "2009",
language = "Deutsch",
volume = "1264",
pages = "1--6",
journal = "BRAIN RES",
issn = "0006-8993",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Association of SORL1 gene variants with Alzheimer's disease.

AU - Kölsch, Heike

AU - Jessen, Frank

AU - Wiltfang, Jens

AU - Lewczuk, Piotr

AU - Dichgans, Martin

AU - Teipel, Stefan J

AU - Kornhuber, Johannes

AU - Frölich, Lutz

AU - Heuser, Isabella

AU - Peters, Oliver

AU - Wiese, Birgitt

AU - Kaduszkiewicz, Hanna

AU - Bussche van den, Hendrik

AU - Hüll, Michael

AU - Kurz, Alexander

AU - Rüther, Eckhart

AU - Henn, Fritz A

AU - Maier, Wolfgang

PY - 2009

Y1 - 2009

N2 - SORL1 gene variants were described as risk factor of Alzheimer's disease (AD) additionally SORL1 gene variants were associated with altered Abeta(42) CSF levels in AD patients. In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias. The SNP21G-allele and a SORL1 haplotype consisting of the SNP19 T-allele, SNP21 G-allele and SNP23 A-allele (T/G/A) were associated with increased hazard ratios and an earlier age at onset of AD (SNP21: p=0.002; T/G/A haplotype: p=0.007). This effect was most pronounced in carriers of an additional APOE4 allele (SNP21: p=0.003; T/G/A haplotype: p=0.005). In conclusion, we found SORL1 gene variants located in the 3' region of the gene to be associated with increased AD risk and an earlier age at onset of AD in our Central-European population. Thus, our data support a role of SORL1 polymorphisms in AD.

AB - SORL1 gene variants were described as risk factor of Alzheimer's disease (AD) additionally SORL1 gene variants were associated with altered Abeta(42) CSF levels in AD patients. In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias. The SNP21G-allele and a SORL1 haplotype consisting of the SNP19 T-allele, SNP21 G-allele and SNP23 A-allele (T/G/A) were associated with increased hazard ratios and an earlier age at onset of AD (SNP21: p=0.002; T/G/A haplotype: p=0.007). This effect was most pronounced in carriers of an additional APOE4 allele (SNP21: p=0.003; T/G/A haplotype: p=0.005). In conclusion, we found SORL1 gene variants located in the 3' region of the gene to be associated with increased AD risk and an earlier age at onset of AD in our Central-European population. Thus, our data support a role of SORL1 polymorphisms in AD.

M3 - SCORING: Zeitschriftenaufsatz

VL - 1264

SP - 1

EP - 6

JO - BRAIN RES

JF - BRAIN RES

SN - 0006-8993

ER -