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Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea

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Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea : A SERVE-Heart Failure substudy analysis. / Javed, Faizan; Tamisier, Renaud; Pepin, Jean-Louis; Cowie, Martin R; Wegscheider, Karl; Angermann, Christiane; d'Ortho, Marie-Pia; Erdmann, Erland; Simonds, Anita K; Somers, Virend K; Teschler, Helmut; Levy, Patrick; Armitstead, Jeff; Woehrle, Holger.

in: RESPIROLOGY, Jahrgang 25, Nr. 3, 03.2020, S. 305-311.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Javed, F, Tamisier, R, Pepin, J-L, Cowie, MR, Wegscheider, K, Angermann, C, d'Ortho, M-P, Erdmann, E, Simonds, AK, Somers, VK, Teschler, H, Levy, P, Armitstead, J & Woehrle, H 2020, 'Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis', RESPIROLOGY, Jg. 25, Nr. 3, S. 305-311. https://doi.org/10.1111/resp.13613

APA

Javed, F., Tamisier, R., Pepin, J-L., Cowie, M. R., Wegscheider, K., Angermann, C., d'Ortho, M-P., Erdmann, E., Simonds, A. K., Somers, V. K., Teschler, H., Levy, P., Armitstead, J., & Woehrle, H. (2020). Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis. RESPIROLOGY, 25(3), 305-311. https://doi.org/10.1111/resp.13613

Vancouver

Javed F, Tamisier R, Pepin J-L, Cowie MR, Wegscheider K, Angermann C et al. Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis. RESPIROLOGY. 2020 Mär;25(3):305-311. https://doi.org/10.1111/resp.13613

Bibtex

@article{42f75cbeb8e249718ab96fa40ff834f4,
title = "Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis",
abstract = "BACKGROUND AND OBJECTIVE: Increases in Cheyne-Stokes respiration (CSR) cycle length (CL), lung-to-periphery circulation time (LPCT) and time to peak flow (TTPF) may reflect impaired cardiac function. This retrospective analysis used an automatic algorithm to evaluate baseline CSR-related features and then determined whether these could be used to identify patients with systolic heart failure (HF) who experienced serious adverse events in the Treatment of Sleep-Disordered Breathing with Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure (SERVE-HF) substudy.METHODS: A total of 280 patients had overnight diagnostic polysomnography data available; an automated algorithm was applied to quantify CSR-related features.RESULTS: Median baseline CL, LPCT and TTPF were similar in the control (n = 152) and adaptive servo-ventilation (ASV, n = 156) groups. In both groups, CSR-related features were significantly longer in patients who did (n = 129) versus did not (n = 140) experience a primary endpoint event (all-cause death, life-saving cardiovascular intervention or unplanned hospitalization for worsening HF): CL, 61.1 versus 55.1 s (P = 0.002); LPCT, 36.5 versus 31.5 s (P < 0.001); TTPF, 15.20 versus 13.35 s (P < 0.001), respectively. This finding was independent of treatment allocation.CONCLUSION: Patients with systolic HF and central sleep apnoea who experienced serious adverse events had longer CSR CL, LPCT and TTPF. Future studies should examine an independent role for CSR-related features to enable risk stratification in systolic HF.",
author = "Faizan Javed and Renaud Tamisier and Jean-Louis Pepin and Cowie, {Martin R} and Karl Wegscheider and Christiane Angermann and Marie-Pia d'Ortho and Erland Erdmann and Simonds, {Anita K} and Somers, {Virend K} and Helmut Teschler and Patrick Levy and Jeff Armitstead and Holger Woehrle",
note = "{\textcopyright} 2019 Asian Pacific Society of Respirology.",
year = "2020",
month = mar,
doi = "10.1111/resp.13613",
language = "English",
volume = "25",
pages = "305--311",
journal = "RESPIROLOGY",
issn = "1323-7799",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea

T2 - A SERVE-Heart Failure substudy analysis

AU - Javed, Faizan

AU - Tamisier, Renaud

AU - Pepin, Jean-Louis

AU - Cowie, Martin R

AU - Wegscheider, Karl

AU - Angermann, Christiane

AU - d'Ortho, Marie-Pia

AU - Erdmann, Erland

AU - Simonds, Anita K

AU - Somers, Virend K

AU - Teschler, Helmut

AU - Levy, Patrick

AU - Armitstead, Jeff

AU - Woehrle, Holger

N1 - © 2019 Asian Pacific Society of Respirology.

PY - 2020/3

Y1 - 2020/3

N2 - BACKGROUND AND OBJECTIVE: Increases in Cheyne-Stokes respiration (CSR) cycle length (CL), lung-to-periphery circulation time (LPCT) and time to peak flow (TTPF) may reflect impaired cardiac function. This retrospective analysis used an automatic algorithm to evaluate baseline CSR-related features and then determined whether these could be used to identify patients with systolic heart failure (HF) who experienced serious adverse events in the Treatment of Sleep-Disordered Breathing with Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure (SERVE-HF) substudy.METHODS: A total of 280 patients had overnight diagnostic polysomnography data available; an automated algorithm was applied to quantify CSR-related features.RESULTS: Median baseline CL, LPCT and TTPF were similar in the control (n = 152) and adaptive servo-ventilation (ASV, n = 156) groups. In both groups, CSR-related features were significantly longer in patients who did (n = 129) versus did not (n = 140) experience a primary endpoint event (all-cause death, life-saving cardiovascular intervention or unplanned hospitalization for worsening HF): CL, 61.1 versus 55.1 s (P = 0.002); LPCT, 36.5 versus 31.5 s (P < 0.001); TTPF, 15.20 versus 13.35 s (P < 0.001), respectively. This finding was independent of treatment allocation.CONCLUSION: Patients with systolic HF and central sleep apnoea who experienced serious adverse events had longer CSR CL, LPCT and TTPF. Future studies should examine an independent role for CSR-related features to enable risk stratification in systolic HF.

AB - BACKGROUND AND OBJECTIVE: Increases in Cheyne-Stokes respiration (CSR) cycle length (CL), lung-to-periphery circulation time (LPCT) and time to peak flow (TTPF) may reflect impaired cardiac function. This retrospective analysis used an automatic algorithm to evaluate baseline CSR-related features and then determined whether these could be used to identify patients with systolic heart failure (HF) who experienced serious adverse events in the Treatment of Sleep-Disordered Breathing with Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure (SERVE-HF) substudy.METHODS: A total of 280 patients had overnight diagnostic polysomnography data available; an automated algorithm was applied to quantify CSR-related features.RESULTS: Median baseline CL, LPCT and TTPF were similar in the control (n = 152) and adaptive servo-ventilation (ASV, n = 156) groups. In both groups, CSR-related features were significantly longer in patients who did (n = 129) versus did not (n = 140) experience a primary endpoint event (all-cause death, life-saving cardiovascular intervention or unplanned hospitalization for worsening HF): CL, 61.1 versus 55.1 s (P = 0.002); LPCT, 36.5 versus 31.5 s (P < 0.001); TTPF, 15.20 versus 13.35 s (P < 0.001), respectively. This finding was independent of treatment allocation.CONCLUSION: Patients with systolic HF and central sleep apnoea who experienced serious adverse events had longer CSR CL, LPCT and TTPF. Future studies should examine an independent role for CSR-related features to enable risk stratification in systolic HF.

U2 - 10.1111/resp.13613

DO - 10.1111/resp.13613

M3 - SCORING: Journal article

C2 - 31218793

VL - 25

SP - 305

EP - 311

JO - RESPIROLOGY

JF - RESPIROLOGY

SN - 1323-7799

IS - 3

ER -