Association of progesterone receptor polymorphism with recurrent abortions.
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Association of progesterone receptor polymorphism with recurrent abortions. / Schweikert, Andreas; Rau, Thomas; Berkholz, Alexander; Allera, Axel; Daufeldt, Sabine; Wildt, Ludwig.
in: EUR J OBSTET GYN R B, Jahrgang 113, Nr. 1, 1, 2004, S. 67-72.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Association of progesterone receptor polymorphism with recurrent abortions.
AU - Schweikert, Andreas
AU - Rau, Thomas
AU - Berkholz, Alexander
AU - Allera, Axel
AU - Daufeldt, Sabine
AU - Wildt, Ludwig
PY - 2004
Y1 - 2004
N2 - OBJECTIVE: The current study sought for polymorphisms within the progesterone receptor (PR) gene. Allele and genotype frequencies of patients with repeated abortions were compared to a control group. DESIGN: All exons of the PR of 42 women with repeated abortions and 40 controls were screened for single nucleotide polymorphisms (SNP). Determination of the DNA-sequences was performed. RESULTS: Three SNPs were detected (exon 1: G1031C Ser344Thr; exon 4: G1978T Leu660Val, exon 5: C2310T His770His). These SNPs are linked. The more frequent wildtype (*1) allele and the rarer (*2) allele were found in the control group and in the study group at different frequencies (control group: *1/*1: 78%, *1/*2: 22%, *2/*2: 0%; patient group: *1/*1: 50%, *1/*2: 43%, *2/*2: 7%). The genotypes distributions differed significantly from each other (P=0.019, chi2=7.879). CONCLUSIONS: The data suggest that the rarer PR allele may be associated with an increased likelihood of repeated miscarriages contributing to its multi-factorial causes.
AB - OBJECTIVE: The current study sought for polymorphisms within the progesterone receptor (PR) gene. Allele and genotype frequencies of patients with repeated abortions were compared to a control group. DESIGN: All exons of the PR of 42 women with repeated abortions and 40 controls were screened for single nucleotide polymorphisms (SNP). Determination of the DNA-sequences was performed. RESULTS: Three SNPs were detected (exon 1: G1031C Ser344Thr; exon 4: G1978T Leu660Val, exon 5: C2310T His770His). These SNPs are linked. The more frequent wildtype (*1) allele and the rarer (*2) allele were found in the control group and in the study group at different frequencies (control group: *1/*1: 78%, *1/*2: 22%, *2/*2: 0%; patient group: *1/*1: 50%, *1/*2: 43%, *2/*2: 7%). The genotypes distributions differed significantly from each other (P=0.019, chi2=7.879). CONCLUSIONS: The data suggest that the rarer PR allele may be associated with an increased likelihood of repeated miscarriages contributing to its multi-factorial causes.
M3 - SCORING: Zeitschriftenaufsatz
VL - 113
SP - 67
EP - 72
JO - EUR J OBSTET GYN R B
JF - EUR J OBSTET GYN R B
SN - 0301-2115
IS - 1
M1 - 1
ER -
