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Association of obesity with disease outcome in multiple sclerosis

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Association of obesity with disease outcome in multiple sclerosis. / Lutfullin, Isabel; Eveslage, Maria; Bittner, Stefan; Antony, Gisela; Flaskamp, Martina; Luessi, Felix; Salmen, Anke; Gisevius, Barbara; Klotz, Luisa; Korsukewitz, Catharina; Berthele, Achim; Groppa, Sergiu; Then Bergh, Florian; Wildemann, Brigitte; Bayas, Antonios; Tumani, Hayrettin; Meuth, Sven G; Trebst, Corinna; Zettl, Uwe K; Paul, Friedemann; Heesen, Christoph; Kuempfel, Tania; Gold, Ralf; Hemmer, Bernhard; Zipp, Frauke; Wiendl, Heinz; Lünemann, Jan D; German Competence Network Multiple Sclerosis (KKNMS).

in: J NEUROL NEUROSUR PS, Jahrgang 94, Nr. 1, 01.2023, S. 57-61.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lutfullin, I, Eveslage, M, Bittner, S, Antony, G, Flaskamp, M, Luessi, F, Salmen, A, Gisevius, B, Klotz, L, Korsukewitz, C, Berthele, A, Groppa, S, Then Bergh, F, Wildemann, B, Bayas, A, Tumani, H, Meuth, SG, Trebst, C, Zettl, UK, Paul, F, Heesen, C, Kuempfel, T, Gold, R, Hemmer, B, Zipp, F, Wiendl, H, Lünemann, JD & German Competence Network Multiple Sclerosis (KKNMS) 2023, 'Association of obesity with disease outcome in multiple sclerosis', J NEUROL NEUROSUR PS, Jg. 94, Nr. 1, S. 57-61. https://doi.org/10.1136/jnnp-2022-329685

APA

Lutfullin, I., Eveslage, M., Bittner, S., Antony, G., Flaskamp, M., Luessi, F., Salmen, A., Gisevius, B., Klotz, L., Korsukewitz, C., Berthele, A., Groppa, S., Then Bergh, F., Wildemann, B., Bayas, A., Tumani, H., Meuth, S. G., Trebst, C., Zettl, U. K., ... German Competence Network Multiple Sclerosis (KKNMS) (2023). Association of obesity with disease outcome in multiple sclerosis. J NEUROL NEUROSUR PS, 94(1), 57-61. https://doi.org/10.1136/jnnp-2022-329685

Vancouver

Lutfullin I, Eveslage M, Bittner S, Antony G, Flaskamp M, Luessi F et al. Association of obesity with disease outcome in multiple sclerosis. J NEUROL NEUROSUR PS. 2023 Jan;94(1):57-61. https://doi.org/10.1136/jnnp-2022-329685

Bibtex

@article{616bc2ae17d447e0849f6a44472fc752,
title = "Association of obesity with disease outcome in multiple sclerosis",
abstract = "BACKGROUND: Obesity reportedly increases the risk for developing multiple sclerosis (MS), but little is known about its association with disability accumulation.METHODS: This nationwide longitudinal cohort study included 1066 individuals with newly diagnosed MS from the German National MS cohort. Expanded Disability Status Scale (EDSS) scores, relapse rates, MRI findings and choice of immunotherapy were compared at baseline and at years 2, 4 and 6 between obese (body mass index, BMI ≥30 kg/m2) and non-obese (BMI <30 kg/m2) patients and correlated with individual BMI values.RESULTS: Presence of obesity at disease onset was associated with higher disability at baseline and at 2, 4 and 6 years of follow-up (p<0.001). Median time to reach EDSS 3 was 0.99 years for patients with BMI ≥30 kg/m2 and 1.46 years for non-obese patients. Risk to reach EDSS 3 over 6 years was significantly increased in patients with BMI ≥30 kg/m2 compared with patients with BMI <30 kg/m2 after adjustment for sex, age, smoking (HR 1.87; 95% CI 1.3 to 2.6; log-rank test p<0.001) and independent of disease-modifying therapies. Obesity was not significantly associated with higher relapse rates, increased number of contrast-enhancing MRI lesions or higher MRI T2 lesion burden over 6 years of follow-up.CONCLUSIONS: Obesity in newly diagnosed patients with MS is associated with higher disease severity and poorer outcome. Obesity management could improve clinical outcome of MS.",
author = "Isabel Lutfullin and Maria Eveslage and Stefan Bittner and Gisela Antony and Martina Flaskamp and Felix Luessi and Anke Salmen and Barbara Gisevius and Luisa Klotz and Catharina Korsukewitz and Achim Berthele and Sergiu Groppa and {Then Bergh}, Florian and Brigitte Wildemann and Antonios Bayas and Hayrettin Tumani and Meuth, {Sven G} and Corinna Trebst and Zettl, {Uwe K} and Friedemann Paul and Christoph Heesen and Tania Kuempfel and Ralf Gold and Bernhard Hemmer and Frauke Zipp and Heinz Wiendl and L{\"u}nemann, {Jan D} and {German Competence Network Multiple Sclerosis (KKNMS)}",
note = "{\textcopyright} Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2023",
month = jan,
doi = "10.1136/jnnp-2022-329685",
language = "English",
volume = "94",
pages = "57--61",
journal = "J NEUROL NEUROSUR PS",
issn = "0022-3050",
publisher = "BMJ PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Association of obesity with disease outcome in multiple sclerosis

AU - Lutfullin, Isabel

AU - Eveslage, Maria

AU - Bittner, Stefan

AU - Antony, Gisela

AU - Flaskamp, Martina

AU - Luessi, Felix

AU - Salmen, Anke

AU - Gisevius, Barbara

AU - Klotz, Luisa

AU - Korsukewitz, Catharina

AU - Berthele, Achim

AU - Groppa, Sergiu

AU - Then Bergh, Florian

AU - Wildemann, Brigitte

AU - Bayas, Antonios

AU - Tumani, Hayrettin

AU - Meuth, Sven G

AU - Trebst, Corinna

AU - Zettl, Uwe K

AU - Paul, Friedemann

AU - Heesen, Christoph

AU - Kuempfel, Tania

AU - Gold, Ralf

AU - Hemmer, Bernhard

AU - Zipp, Frauke

AU - Wiendl, Heinz

AU - Lünemann, Jan D

AU - German Competence Network Multiple Sclerosis (KKNMS)

N1 - © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2023/1

Y1 - 2023/1

N2 - BACKGROUND: Obesity reportedly increases the risk for developing multiple sclerosis (MS), but little is known about its association with disability accumulation.METHODS: This nationwide longitudinal cohort study included 1066 individuals with newly diagnosed MS from the German National MS cohort. Expanded Disability Status Scale (EDSS) scores, relapse rates, MRI findings and choice of immunotherapy were compared at baseline and at years 2, 4 and 6 between obese (body mass index, BMI ≥30 kg/m2) and non-obese (BMI <30 kg/m2) patients and correlated with individual BMI values.RESULTS: Presence of obesity at disease onset was associated with higher disability at baseline and at 2, 4 and 6 years of follow-up (p<0.001). Median time to reach EDSS 3 was 0.99 years for patients with BMI ≥30 kg/m2 and 1.46 years for non-obese patients. Risk to reach EDSS 3 over 6 years was significantly increased in patients with BMI ≥30 kg/m2 compared with patients with BMI <30 kg/m2 after adjustment for sex, age, smoking (HR 1.87; 95% CI 1.3 to 2.6; log-rank test p<0.001) and independent of disease-modifying therapies. Obesity was not significantly associated with higher relapse rates, increased number of contrast-enhancing MRI lesions or higher MRI T2 lesion burden over 6 years of follow-up.CONCLUSIONS: Obesity in newly diagnosed patients with MS is associated with higher disease severity and poorer outcome. Obesity management could improve clinical outcome of MS.

AB - BACKGROUND: Obesity reportedly increases the risk for developing multiple sclerosis (MS), but little is known about its association with disability accumulation.METHODS: This nationwide longitudinal cohort study included 1066 individuals with newly diagnosed MS from the German National MS cohort. Expanded Disability Status Scale (EDSS) scores, relapse rates, MRI findings and choice of immunotherapy were compared at baseline and at years 2, 4 and 6 between obese (body mass index, BMI ≥30 kg/m2) and non-obese (BMI <30 kg/m2) patients and correlated with individual BMI values.RESULTS: Presence of obesity at disease onset was associated with higher disability at baseline and at 2, 4 and 6 years of follow-up (p<0.001). Median time to reach EDSS 3 was 0.99 years for patients with BMI ≥30 kg/m2 and 1.46 years for non-obese patients. Risk to reach EDSS 3 over 6 years was significantly increased in patients with BMI ≥30 kg/m2 compared with patients with BMI <30 kg/m2 after adjustment for sex, age, smoking (HR 1.87; 95% CI 1.3 to 2.6; log-rank test p<0.001) and independent of disease-modifying therapies. Obesity was not significantly associated with higher relapse rates, increased number of contrast-enhancing MRI lesions or higher MRI T2 lesion burden over 6 years of follow-up.CONCLUSIONS: Obesity in newly diagnosed patients with MS is associated with higher disease severity and poorer outcome. Obesity management could improve clinical outcome of MS.

U2 - 10.1136/jnnp-2022-329685

DO - 10.1136/jnnp-2022-329685

M3 - SCORING: Journal article

C2 - 36319190

VL - 94

SP - 57

EP - 61

JO - J NEUROL NEUROSUR PS

JF - J NEUROL NEUROSUR PS

SN - 0022-3050

IS - 1

ER -