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Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon

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Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon. / Honkpéhèdji, Yabo Josiane; Adegbite, Bayode Romeo; Zinsou, Jeannot Fréjus; Dejon-Agobé, Jean Claude; Edoa, Jean-Ronald; Zoleko Manego, Rella; McCall, Matthew; Mbong Ngwese, Mirabeau; Lotola Mougeni, Fabrice; Mombo-Ngoma, Ghyslain; Ramharter, Michael; Kremsner, Peter G; Lell, Bertrand; Yazdanbakhsh, Maria; Esen, Meral; Adegnika, Ayôla Akim.

in: TROP MED INT HEALTH, Jahrgang 26, Nr. 8, 08.2021, S. 973-981.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Honkpéhèdji, YJ, Adegbite, BR, Zinsou, JF, Dejon-Agobé, JC, Edoa, J-R, Zoleko Manego, R, McCall, M, Mbong Ngwese, M, Lotola Mougeni, F, Mombo-Ngoma, G, Ramharter, M, Kremsner, PG, Lell, B, Yazdanbakhsh, M, Esen, M & Adegnika, AA 2021, 'Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon', TROP MED INT HEALTH, Jg. 26, Nr. 8, S. 973-981. https://doi.org/10.1111/tmi.13591

APA

Honkpéhèdji, Y. J., Adegbite, B. R., Zinsou, J. F., Dejon-Agobé, J. C., Edoa, J-R., Zoleko Manego, R., McCall, M., Mbong Ngwese, M., Lotola Mougeni, F., Mombo-Ngoma, G., Ramharter, M., Kremsner, P. G., Lell, B., Yazdanbakhsh, M., Esen, M., & Adegnika, A. A. (2021). Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon. TROP MED INT HEALTH, 26(8), 973-981. https://doi.org/10.1111/tmi.13591

Vancouver

Honkpéhèdji YJ, Adegbite BR, Zinsou JF, Dejon-Agobé JC, Edoa J-R, Zoleko Manego R et al. Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon. TROP MED INT HEALTH. 2021 Aug;26(8):973-981. https://doi.org/10.1111/tmi.13591

Bibtex

@article{40b9878fc1a1412bb9f06b32fad011f6,
title = "Association of low birth weight and polyparasitic infection during pregnancy in Lambar{\'e}n{\'e}, Gabon",
abstract = "OBJECTIVE: To report the prevalence of polyparasitism during pregnancy in the Lambar{\'e}n{\'e} region of Gabon and its association with newborn birth weight.METHOD: Pregnant women in their third trimester were recruited in a prospective study between November 2011 and March 2015. Parasite infection status was assessed microscopically in stool, urine and blood samples. Maternal demographic and obstetrical characteristics and newborns anthropometric data were collected. Multivariable logistic regression was used to assess the association between low birth weight and polyparasitism.RESULTS: 678 of 927 pregnant women were included for analysis with mean age (SD) of 25 (6.8) years. The analysis showed that 69% (468/678) were infected with at least one parasite (Plasmodium spp., Schistosoma spp., soil-transmitted helminths, filarial infections). This comprised of 38% with monoparasitism and 31% polyparasitism. The proportion of newborn babies with a weight below 2500 g (LBW) in our study was 21% (142/678). Compared to pregnant women without infection, women with monoparasitic infection had adjusted Odds Ratio confidence interval 95% CI (aOR [95%CI]) of 1.6 [0.95-2.73], those with two parasites had aOR 95%CI of 2.63 [1.51-4.62], and those with more than two parasites had aOR of 5.08 [2.5-10.38] for delivering a newborn with low birth weight.CONCLUSION: In Lambar{\'e}n{\'e}, an endemic area for multiple parasite infections, there is a high prevalence of polyparasitism in pregnant women. Polyparasitism is associated with low birth weight. Therefore, there is an urgent need for active screening and treatment of parasite infections in pregnant women to assess the potential public health benefit of such interventions.",
keywords = "Adolescent, Adult, Birth Weight, Female, Gabon/epidemiology, Humans, Infant, Low Birth Weight, Infant, Newborn, Male, Parasitic Diseases/epidemiology, Pregnancy, Pregnancy Complications, Infectious/epidemiology, Prenatal Care, Young Adult",
author = "Honkp{\'e}h{\`e}dji, {Yabo Josiane} and Adegbite, {Bayode Romeo} and Zinsou, {Jeannot Fr{\'e}jus} and Dejon-Agob{\'e}, {Jean Claude} and Jean-Ronald Edoa and {Zoleko Manego}, Rella and Matthew McCall and {Mbong Ngwese}, Mirabeau and {Lotola Mougeni}, Fabrice and Ghyslain Mombo-Ngoma and Michael Ramharter and Kremsner, {Peter G} and Bertrand Lell and Maria Yazdanbakhsh and Meral Esen and Adegnika, {Ay{\^o}la Akim}",
note = "{\textcopyright} 2021 John Wiley & Sons Ltd.",
year = "2021",
month = aug,
doi = "10.1111/tmi.13591",
language = "English",
volume = "26",
pages = "973--981",
journal = "TROP MED INT HEALTH",
issn = "1360-2276",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS

TY - JOUR

T1 - Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon

AU - Honkpéhèdji, Yabo Josiane

AU - Adegbite, Bayode Romeo

AU - Zinsou, Jeannot Fréjus

AU - Dejon-Agobé, Jean Claude

AU - Edoa, Jean-Ronald

AU - Zoleko Manego, Rella

AU - McCall, Matthew

AU - Mbong Ngwese, Mirabeau

AU - Lotola Mougeni, Fabrice

AU - Mombo-Ngoma, Ghyslain

AU - Ramharter, Michael

AU - Kremsner, Peter G

AU - Lell, Bertrand

AU - Yazdanbakhsh, Maria

AU - Esen, Meral

AU - Adegnika, Ayôla Akim

N1 - © 2021 John Wiley & Sons Ltd.

PY - 2021/8

Y1 - 2021/8

N2 - OBJECTIVE: To report the prevalence of polyparasitism during pregnancy in the Lambaréné region of Gabon and its association with newborn birth weight.METHOD: Pregnant women in their third trimester were recruited in a prospective study between November 2011 and March 2015. Parasite infection status was assessed microscopically in stool, urine and blood samples. Maternal demographic and obstetrical characteristics and newborns anthropometric data were collected. Multivariable logistic regression was used to assess the association between low birth weight and polyparasitism.RESULTS: 678 of 927 pregnant women were included for analysis with mean age (SD) of 25 (6.8) years. The analysis showed that 69% (468/678) were infected with at least one parasite (Plasmodium spp., Schistosoma spp., soil-transmitted helminths, filarial infections). This comprised of 38% with monoparasitism and 31% polyparasitism. The proportion of newborn babies with a weight below 2500 g (LBW) in our study was 21% (142/678). Compared to pregnant women without infection, women with monoparasitic infection had adjusted Odds Ratio confidence interval 95% CI (aOR [95%CI]) of 1.6 [0.95-2.73], those with two parasites had aOR 95%CI of 2.63 [1.51-4.62], and those with more than two parasites had aOR of 5.08 [2.5-10.38] for delivering a newborn with low birth weight.CONCLUSION: In Lambaréné, an endemic area for multiple parasite infections, there is a high prevalence of polyparasitism in pregnant women. Polyparasitism is associated with low birth weight. Therefore, there is an urgent need for active screening and treatment of parasite infections in pregnant women to assess the potential public health benefit of such interventions.

AB - OBJECTIVE: To report the prevalence of polyparasitism during pregnancy in the Lambaréné region of Gabon and its association with newborn birth weight.METHOD: Pregnant women in their third trimester were recruited in a prospective study between November 2011 and March 2015. Parasite infection status was assessed microscopically in stool, urine and blood samples. Maternal demographic and obstetrical characteristics and newborns anthropometric data were collected. Multivariable logistic regression was used to assess the association between low birth weight and polyparasitism.RESULTS: 678 of 927 pregnant women were included for analysis with mean age (SD) of 25 (6.8) years. The analysis showed that 69% (468/678) were infected with at least one parasite (Plasmodium spp., Schistosoma spp., soil-transmitted helminths, filarial infections). This comprised of 38% with monoparasitism and 31% polyparasitism. The proportion of newborn babies with a weight below 2500 g (LBW) in our study was 21% (142/678). Compared to pregnant women without infection, women with monoparasitic infection had adjusted Odds Ratio confidence interval 95% CI (aOR [95%CI]) of 1.6 [0.95-2.73], those with two parasites had aOR 95%CI of 2.63 [1.51-4.62], and those with more than two parasites had aOR of 5.08 [2.5-10.38] for delivering a newborn with low birth weight.CONCLUSION: In Lambaréné, an endemic area for multiple parasite infections, there is a high prevalence of polyparasitism in pregnant women. Polyparasitism is associated with low birth weight. Therefore, there is an urgent need for active screening and treatment of parasite infections in pregnant women to assess the potential public health benefit of such interventions.

KW - Adolescent

KW - Adult

KW - Birth Weight

KW - Female

KW - Gabon/epidemiology

KW - Humans

KW - Infant, Low Birth Weight

KW - Infant, Newborn

KW - Male

KW - Parasitic Diseases/epidemiology

KW - Pregnancy

KW - Pregnancy Complications, Infectious/epidemiology

KW - Prenatal Care

KW - Young Adult

U2 - 10.1111/tmi.13591

DO - 10.1111/tmi.13591

M3 - SCORING: Journal article

C2 - 33860600

VL - 26

SP - 973

EP - 981

JO - TROP MED INT HEALTH

JF - TROP MED INT HEALTH

SN - 1360-2276

IS - 8

ER -