Association of Frailty with Adverse Outcomes in Patients with Suspected COVID-19 Infection
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Association of Frailty with Adverse Outcomes in Patients with Suspected COVID-19 Infection. / Simon, Noemi R; Jauslin, Andrea S; Rueegg, Marco; Twerenbold, Raphael; Lampart, Maurin; Osswald, Stefan; Bassetti, Stefano; Tschudin-Sutter, Sarah; Siegemund, Martin; Nickel, Christian H; Bingisser, Roland.
in: J CLIN MED, Jahrgang 10, Nr. 11, 2472, 02.06.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Association of Frailty with Adverse Outcomes in Patients with Suspected COVID-19 Infection
AU - Simon, Noemi R
AU - Jauslin, Andrea S
AU - Rueegg, Marco
AU - Twerenbold, Raphael
AU - Lampart, Maurin
AU - Osswald, Stefan
AU - Bassetti, Stefano
AU - Tschudin-Sutter, Sarah
AU - Siegemund, Martin
AU - Nickel, Christian H
AU - Bingisser, Roland
PY - 2021/6/2
Y1 - 2021/6/2
N2 - Older age and frailty are predictors of adverse outcomes in patients with COVID-19. In emergency medicine, patients do not present with the diagnosis, but with suspicion of COVID-19. The aim of this study was to assess the association of frailty and age with death or admission to intensive care in patients with suspected COVID-19. This single-centre prospective cohort study was performed in the Emergency Department of a tertiary care hospital. Patients, 65 years and older, with suspected COVID-19 presenting to the Emergency Department during the first wave of the pandemic were consecutively enrolled. All patients underwent nasopharyngeal SARS-CoV-2 PCR swab tests. Patients with a Clinical Frailty Scale (CFS) > 4, were considered to be frail. Associations between age, gender, frailty, and COVID-19 status with the composite adverse outcome of 30-day-intensive-care-admission and/or 30-day-mortality were tested. In the 372 patients analysed, the median age was 77 years, 154 (41.4%) were women, 44 (11.8%) were COVID-19-positive, and 125 (33.6%) were frail. The worst outcome was seen in frail COVID-19-patients with six (66.7%) adverse outcomes. Frailty (CFS > 4) and COVID-19-positivity were associated with an adverse outcome after adjustment for age and gender (frailty: OR 5.01, CI 2.56-10.17, p < 0.001; COVID-19: OR 3.47, CI 1.48-7.89, p = 0.003). Frailty was strongly associated with adverse outcomes and outperformed age as a predictor in emergency patients with suspected COVID-19.
AB - Older age and frailty are predictors of adverse outcomes in patients with COVID-19. In emergency medicine, patients do not present with the diagnosis, but with suspicion of COVID-19. The aim of this study was to assess the association of frailty and age with death or admission to intensive care in patients with suspected COVID-19. This single-centre prospective cohort study was performed in the Emergency Department of a tertiary care hospital. Patients, 65 years and older, with suspected COVID-19 presenting to the Emergency Department during the first wave of the pandemic were consecutively enrolled. All patients underwent nasopharyngeal SARS-CoV-2 PCR swab tests. Patients with a Clinical Frailty Scale (CFS) > 4, were considered to be frail. Associations between age, gender, frailty, and COVID-19 status with the composite adverse outcome of 30-day-intensive-care-admission and/or 30-day-mortality were tested. In the 372 patients analysed, the median age was 77 years, 154 (41.4%) were women, 44 (11.8%) were COVID-19-positive, and 125 (33.6%) were frail. The worst outcome was seen in frail COVID-19-patients with six (66.7%) adverse outcomes. Frailty (CFS > 4) and COVID-19-positivity were associated with an adverse outcome after adjustment for age and gender (frailty: OR 5.01, CI 2.56-10.17, p < 0.001; COVID-19: OR 3.47, CI 1.48-7.89, p = 0.003). Frailty was strongly associated with adverse outcomes and outperformed age as a predictor in emergency patients with suspected COVID-19.
U2 - 10.3390/jcm10112472
DO - 10.3390/jcm10112472
M3 - SCORING: Journal article
C2 - 34199572
VL - 10
JO - J CLIN MED
JF - J CLIN MED
SN - 2077-0383
IS - 11
M1 - 2472
ER -