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Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis.

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Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. / Frank, Bernd; Wiestler, Miriam; Kropp, Silke; Hemminki, Kari; Spurdle, Amanda B; Sutter, Christian; Wappenschmidt, Barbara; Chen, Xiaoqing; Beesley, Jonathan; Hopper, John L; Meindl, Alfons; Kiechle, Marion; Slanger, Tracy; Bugert, Peter; Schmutzler, Rita K; Bartram, Claus R; Flesch-Janys, Dieter; Mutschelknauss, Elke; Ashton, Katie; Salazar, Ramona; Webb, Emily; Hamann, Ute; Brauch, Hiltrud; Justenhoven, Christina; Ko, Yon-Dschun; Brüning, Thomas; Silva, Isabel Dos Santos; Johnson, Nichola; Pharoah, Paul P D; Dunning, Alison M; Pooley, Karen A; Chang-Claude, Jenny; Easton, Douglas F; Peto, Julian; Houlston, Richard; Chenevix-Trench, Georgia; Fletcher, Olivia; Burwinkel, Barbara.

in: JNCI-J NATL CANCER I, Jahrgang 100, Nr. 6, 6, 2008, S. 437-442.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Frank, B, Wiestler, M, Kropp, S, Hemminki, K, Spurdle, AB, Sutter, C, Wappenschmidt, B, Chen, X, Beesley, J, Hopper, JL, Meindl, A, Kiechle, M, Slanger, T, Bugert, P, Schmutzler, RK, Bartram, CR, Flesch-Janys, D, Mutschelknauss, E, Ashton, K, Salazar, R, Webb, E, Hamann, U, Brauch, H, Justenhoven, C, Ko, Y-D, Brüning, T, Silva, IDS, Johnson, N, Pharoah, PPD, Dunning, AM, Pooley, KA, Chang-Claude, J, Easton, DF, Peto, J, Houlston, R, Chenevix-Trench, G, Fletcher, O & Burwinkel, B 2008, 'Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis.', JNCI-J NATL CANCER I, Jg. 100, Nr. 6, 6, S. 437-442. <http://www.ncbi.nlm.nih.gov/pubmed/18334708?dopt=Citation>

APA

Frank, B., Wiestler, M., Kropp, S., Hemminki, K., Spurdle, A. B., Sutter, C., Wappenschmidt, B., Chen, X., Beesley, J., Hopper, J. L., Meindl, A., Kiechle, M., Slanger, T., Bugert, P., Schmutzler, R. K., Bartram, C. R., Flesch-Janys, D., Mutschelknauss, E., Ashton, K., ... Burwinkel, B. (2008). Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. JNCI-J NATL CANCER I, 100(6), 437-442. [6]. http://www.ncbi.nlm.nih.gov/pubmed/18334708?dopt=Citation

Vancouver

Frank B, Wiestler M, Kropp S, Hemminki K, Spurdle AB, Sutter C et al. Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. JNCI-J NATL CANCER I. 2008;100(6):437-442. 6.

Bibtex

@article{30acc588277c40e288c4810c5bd37ce6,
title = "Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis.",
abstract = "Data from several studies have suggested that polymorphisms in A-kinase anchoring proteins (AKAPs), which are key components of signal transduction, contribute to carcinogenesis. To evaluate the impact of AKAP variants on breast cancer risk, we genotyped six nonsynonymous single-nucleotide polymorphisms that were predicted to be deleterious and found two (M463I, 1389G>T and N2792S, 8375A>G) to be associated with an allele dose-dependent increase in risk of familial breast cancer in a German population. We extended the analysis of AKAP9 M463I, which is in strong linkage disequilibrium with AKAP9 N2792S, to 9523 breast cancer patients and 13770 healthy control subjects from seven independent European and Australian breast cancer studies. All statistical tests were two-sided. The collaborative analysis confirmed the association of M463I with increased breast cancer risk. Among all breast cancer patients, the combined adjusted odds ratio (OR) of breast cancer for individuals homozygous for the rare allele TT (frequency = 0.19) compared with GG homozygotes was 1.17 (95% confidence interval [CI] = 1.08 to 1.27, P = .0003), and the OR for TT homozygotes plus GT heterozygotes compared with GG homozygotes was 1.10 (95% CI = 1.04 to 1.17, P = .001). Among the combined subset of 2795 familial breast cancer patients, the respective ORs were 1.27 (95% CI = 1.12 to 1.45, P = .0003) and 1.16 (95% CI = 1.06 to 1.27, P = .001).",
author = "Bernd Frank and Miriam Wiestler and Silke Kropp and Kari Hemminki and Spurdle, {Amanda B} and Christian Sutter and Barbara Wappenschmidt and Xiaoqing Chen and Jonathan Beesley and Hopper, {John L} and Alfons Meindl and Marion Kiechle and Tracy Slanger and Peter Bugert and Schmutzler, {Rita K} and Bartram, {Claus R} and Dieter Flesch-Janys and Elke Mutschelknauss and Katie Ashton and Ramona Salazar and Emily Webb and Ute Hamann and Hiltrud Brauch and Christina Justenhoven and Yon-Dschun Ko and Thomas Br{\"u}ning and Silva, {Isabel Dos Santos} and Nichola Johnson and Pharoah, {Paul P D} and Dunning, {Alison M} and Pooley, {Karen A} and Jenny Chang-Claude and Easton, {Douglas F} and Julian Peto and Richard Houlston and Georgia Chenevix-Trench and Olivia Fletcher and Barbara Burwinkel",
year = "2008",
language = "Deutsch",
volume = "100",
pages = "437--442",
journal = "JNCI-J NATL CANCER I",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis.

AU - Frank, Bernd

AU - Wiestler, Miriam

AU - Kropp, Silke

AU - Hemminki, Kari

AU - Spurdle, Amanda B

AU - Sutter, Christian

AU - Wappenschmidt, Barbara

AU - Chen, Xiaoqing

AU - Beesley, Jonathan

AU - Hopper, John L

AU - Meindl, Alfons

AU - Kiechle, Marion

AU - Slanger, Tracy

AU - Bugert, Peter

AU - Schmutzler, Rita K

AU - Bartram, Claus R

AU - Flesch-Janys, Dieter

AU - Mutschelknauss, Elke

AU - Ashton, Katie

AU - Salazar, Ramona

AU - Webb, Emily

AU - Hamann, Ute

AU - Brauch, Hiltrud

AU - Justenhoven, Christina

AU - Ko, Yon-Dschun

AU - Brüning, Thomas

AU - Silva, Isabel Dos Santos

AU - Johnson, Nichola

AU - Pharoah, Paul P D

AU - Dunning, Alison M

AU - Pooley, Karen A

AU - Chang-Claude, Jenny

AU - Easton, Douglas F

AU - Peto, Julian

AU - Houlston, Richard

AU - Chenevix-Trench, Georgia

AU - Fletcher, Olivia

AU - Burwinkel, Barbara

PY - 2008

Y1 - 2008

N2 - Data from several studies have suggested that polymorphisms in A-kinase anchoring proteins (AKAPs), which are key components of signal transduction, contribute to carcinogenesis. To evaluate the impact of AKAP variants on breast cancer risk, we genotyped six nonsynonymous single-nucleotide polymorphisms that were predicted to be deleterious and found two (M463I, 1389G>T and N2792S, 8375A>G) to be associated with an allele dose-dependent increase in risk of familial breast cancer in a German population. We extended the analysis of AKAP9 M463I, which is in strong linkage disequilibrium with AKAP9 N2792S, to 9523 breast cancer patients and 13770 healthy control subjects from seven independent European and Australian breast cancer studies. All statistical tests were two-sided. The collaborative analysis confirmed the association of M463I with increased breast cancer risk. Among all breast cancer patients, the combined adjusted odds ratio (OR) of breast cancer for individuals homozygous for the rare allele TT (frequency = 0.19) compared with GG homozygotes was 1.17 (95% confidence interval [CI] = 1.08 to 1.27, P = .0003), and the OR for TT homozygotes plus GT heterozygotes compared with GG homozygotes was 1.10 (95% CI = 1.04 to 1.17, P = .001). Among the combined subset of 2795 familial breast cancer patients, the respective ORs were 1.27 (95% CI = 1.12 to 1.45, P = .0003) and 1.16 (95% CI = 1.06 to 1.27, P = .001).

AB - Data from several studies have suggested that polymorphisms in A-kinase anchoring proteins (AKAPs), which are key components of signal transduction, contribute to carcinogenesis. To evaluate the impact of AKAP variants on breast cancer risk, we genotyped six nonsynonymous single-nucleotide polymorphisms that were predicted to be deleterious and found two (M463I, 1389G>T and N2792S, 8375A>G) to be associated with an allele dose-dependent increase in risk of familial breast cancer in a German population. We extended the analysis of AKAP9 M463I, which is in strong linkage disequilibrium with AKAP9 N2792S, to 9523 breast cancer patients and 13770 healthy control subjects from seven independent European and Australian breast cancer studies. All statistical tests were two-sided. The collaborative analysis confirmed the association of M463I with increased breast cancer risk. Among all breast cancer patients, the combined adjusted odds ratio (OR) of breast cancer for individuals homozygous for the rare allele TT (frequency = 0.19) compared with GG homozygotes was 1.17 (95% confidence interval [CI] = 1.08 to 1.27, P = .0003), and the OR for TT homozygotes plus GT heterozygotes compared with GG homozygotes was 1.10 (95% CI = 1.04 to 1.17, P = .001). Among the combined subset of 2795 familial breast cancer patients, the respective ORs were 1.27 (95% CI = 1.12 to 1.45, P = .0003) and 1.16 (95% CI = 1.06 to 1.27, P = .001).

M3 - SCORING: Zeitschriftenaufsatz

VL - 100

SP - 437

EP - 442

JO - JNCI-J NATL CANCER I

JF - JNCI-J NATL CANCER I

SN - 0027-8874

IS - 6

M1 - 6

ER -