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Association between the perfusion/diffusion and diffusion/FLAIR mismatch: data from the AXIS2 trial

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Association between the perfusion/diffusion and diffusion/FLAIR mismatch: data from the AXIS2 trial. / Wouters, Anke; Dupont, Patrick; Ringelstein, Erich B; Norrving, Bo; Chamorro, Angel; Grond, Martin; Laage, Rico; Schneider, Armin; Wilms, Guido; Thomalla, Götz; Lemmens, Robin; Thijs, Vincent N.

in: J CEREBR BLOOD F MET, Jahrgang 35, Nr. 10, 10.2015, S. 1681-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wouters, A, Dupont, P, Ringelstein, EB, Norrving, B, Chamorro, A, Grond, M, Laage, R, Schneider, A, Wilms, G, Thomalla, G, Lemmens, R & Thijs, VN 2015, 'Association between the perfusion/diffusion and diffusion/FLAIR mismatch: data from the AXIS2 trial', J CEREBR BLOOD F MET, Jg. 35, Nr. 10, S. 1681-6. https://doi.org/10.1038/jcbfm.2015.108

APA

Wouters, A., Dupont, P., Ringelstein, E. B., Norrving, B., Chamorro, A., Grond, M., Laage, R., Schneider, A., Wilms, G., Thomalla, G., Lemmens, R., & Thijs, V. N. (2015). Association between the perfusion/diffusion and diffusion/FLAIR mismatch: data from the AXIS2 trial. J CEREBR BLOOD F MET, 35(10), 1681-6. https://doi.org/10.1038/jcbfm.2015.108

Vancouver

Wouters A, Dupont P, Ringelstein EB, Norrving B, Chamorro A, Grond M et al. Association between the perfusion/diffusion and diffusion/FLAIR mismatch: data from the AXIS2 trial. J CEREBR BLOOD F MET. 2015 Okt;35(10):1681-6. https://doi.org/10.1038/jcbfm.2015.108

Bibtex

@article{cba179e2880b43568e2aa3ed5bbcfad2,
title = "Association between the perfusion/diffusion and diffusion/FLAIR mismatch: data from the AXIS2 trial",
abstract = "The perfusion-/diffusion-weighted imaging (PWI/DWI) mismatch and the diffusion/fluid attenuated inversion recovery (DWI/FLAIR) mismatch are magnetic resonance imaging (MRI) markers of evolving brain ischemia. We examined whether the DWI/FLAIR mismatch was independently associated with the PWI/DWI mismatch. Furthermore, we determined whether the presence of the DWI/FLAIR mismatch in patients with the PWI/DWI mismatch would provide additional information regarding last seen normal time (LTM). We used data from the 'AX200 for ischemic stroke' trial (AXIS 2 study NCT00927836). We studied the association between the presence of the DWI/FLAIR and PWI/DWI mismatch, baseline National Institute of Health Stroke Scale (NIHSS), age, ischemic-core volume, gender, intravenous (IV) tissue plasminogen activator (tPA), and perfusion-mismatch volume in univariate analysis. Significant variables (P<0.05) were added into the final multivariate model. We analyzed 197 patients. Seventy-two (37%) had both the PWI/DWI and the DWI/FLAIR mismatch. Patients with the double mismatch pattern had a shorter LTM than patients with the PWI/DWI mismatch alone (Median difference 90 minutes, P<0.01). Multivariate analysis confirmed the independent association between the two mismatch patterns (odds ratio (OR) 2.6, 95% confidence interval (CI) 1.2 to 5.4). Our study implies that the DWI/FLAIR mismatch and PWI/DWI mismatch are strongly associated, independent from LTM. Furthermore, in the presence of the PWI/DWI mismatch, the DWI/FLAIR pattern indicates a shorter LTM. This could have implications in selecting patients for reperfusion therapy.",
author = "Anke Wouters and Patrick Dupont and Ringelstein, {Erich B} and Bo Norrving and Angel Chamorro and Martin Grond and Rico Laage and Armin Schneider and Guido Wilms and G{\"o}tz Thomalla and Robin Lemmens and Thijs, {Vincent N}",
year = "2015",
month = oct,
doi = "10.1038/jcbfm.2015.108",
language = "English",
volume = "35",
pages = "1681--6",
journal = "J CEREBR BLOOD F MET",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "10",

}

RIS

TY - JOUR

T1 - Association between the perfusion/diffusion and diffusion/FLAIR mismatch: data from the AXIS2 trial

AU - Wouters, Anke

AU - Dupont, Patrick

AU - Ringelstein, Erich B

AU - Norrving, Bo

AU - Chamorro, Angel

AU - Grond, Martin

AU - Laage, Rico

AU - Schneider, Armin

AU - Wilms, Guido

AU - Thomalla, Götz

AU - Lemmens, Robin

AU - Thijs, Vincent N

PY - 2015/10

Y1 - 2015/10

N2 - The perfusion-/diffusion-weighted imaging (PWI/DWI) mismatch and the diffusion/fluid attenuated inversion recovery (DWI/FLAIR) mismatch are magnetic resonance imaging (MRI) markers of evolving brain ischemia. We examined whether the DWI/FLAIR mismatch was independently associated with the PWI/DWI mismatch. Furthermore, we determined whether the presence of the DWI/FLAIR mismatch in patients with the PWI/DWI mismatch would provide additional information regarding last seen normal time (LTM). We used data from the 'AX200 for ischemic stroke' trial (AXIS 2 study NCT00927836). We studied the association between the presence of the DWI/FLAIR and PWI/DWI mismatch, baseline National Institute of Health Stroke Scale (NIHSS), age, ischemic-core volume, gender, intravenous (IV) tissue plasminogen activator (tPA), and perfusion-mismatch volume in univariate analysis. Significant variables (P<0.05) were added into the final multivariate model. We analyzed 197 patients. Seventy-two (37%) had both the PWI/DWI and the DWI/FLAIR mismatch. Patients with the double mismatch pattern had a shorter LTM than patients with the PWI/DWI mismatch alone (Median difference 90 minutes, P<0.01). Multivariate analysis confirmed the independent association between the two mismatch patterns (odds ratio (OR) 2.6, 95% confidence interval (CI) 1.2 to 5.4). Our study implies that the DWI/FLAIR mismatch and PWI/DWI mismatch are strongly associated, independent from LTM. Furthermore, in the presence of the PWI/DWI mismatch, the DWI/FLAIR pattern indicates a shorter LTM. This could have implications in selecting patients for reperfusion therapy.

AB - The perfusion-/diffusion-weighted imaging (PWI/DWI) mismatch and the diffusion/fluid attenuated inversion recovery (DWI/FLAIR) mismatch are magnetic resonance imaging (MRI) markers of evolving brain ischemia. We examined whether the DWI/FLAIR mismatch was independently associated with the PWI/DWI mismatch. Furthermore, we determined whether the presence of the DWI/FLAIR mismatch in patients with the PWI/DWI mismatch would provide additional information regarding last seen normal time (LTM). We used data from the 'AX200 for ischemic stroke' trial (AXIS 2 study NCT00927836). We studied the association between the presence of the DWI/FLAIR and PWI/DWI mismatch, baseline National Institute of Health Stroke Scale (NIHSS), age, ischemic-core volume, gender, intravenous (IV) tissue plasminogen activator (tPA), and perfusion-mismatch volume in univariate analysis. Significant variables (P<0.05) were added into the final multivariate model. We analyzed 197 patients. Seventy-two (37%) had both the PWI/DWI and the DWI/FLAIR mismatch. Patients with the double mismatch pattern had a shorter LTM than patients with the PWI/DWI mismatch alone (Median difference 90 minutes, P<0.01). Multivariate analysis confirmed the independent association between the two mismatch patterns (odds ratio (OR) 2.6, 95% confidence interval (CI) 1.2 to 5.4). Our study implies that the DWI/FLAIR mismatch and PWI/DWI mismatch are strongly associated, independent from LTM. Furthermore, in the presence of the PWI/DWI mismatch, the DWI/FLAIR pattern indicates a shorter LTM. This could have implications in selecting patients for reperfusion therapy.

U2 - 10.1038/jcbfm.2015.108

DO - 10.1038/jcbfm.2015.108

M3 - SCORING: Journal article

C2 - 26036936

VL - 35

SP - 1681

EP - 1686

JO - J CEREBR BLOOD F MET

JF - J CEREBR BLOOD F MET

SN - 0271-678X

IS - 10

ER -