Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
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Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study. / Mayer, Carola; Nägele, Felix L.; Petersen, Marvin; Schell, Maximilian; Aarabi, Ghazal; Beikler, Thomas; Borof, Katrin; Frey, Benedikt M.; Nikorowitsch, Julius; Senftinger, Juliana; Walther, Carolin; Wenzel, Jan-Per; Zyriax, Birgit-Christiane; Cheng, Bastian; Thomalla, Götz.
in: NUTRIENTS, Jahrgang 15, Nr. 3, 674, 28.01.2023.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
AU - Mayer, Carola
AU - Nägele, Felix L.
AU - Petersen, Marvin
AU - Schell, Maximilian
AU - Aarabi, Ghazal
AU - Beikler, Thomas
AU - Borof, Katrin
AU - Frey, Benedikt M.
AU - Nikorowitsch, Julius
AU - Senftinger, Juliana
AU - Walther, Carolin
AU - Wenzel, Jan-Per
AU - Zyriax, Birgit-Christiane
AU - Cheng, Bastian
AU - Thomalla, Götz
PY - 2023/1/28
Y1 - 2023/1/28
N2 - Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegeneration, and microstructural integrity in 2316 participants in the population-based Hamburg City Health Study. Cortical thickness and white matter hyperintensity (WMH) load were measured on FLAIR and T1-weighted images. Microstructural white matter integrity was quantified as peak width of skeletonized mean diffusivity (PSMD) on diffusion-weighted MRI. Daily coffee consumption was assessed in five groups (<1 cup, 1–2 cups, 3–4 cups, 5–6 cups, >6 cups). In multiple linear regressions, we examined the association between brain MRI parameters and coffee consumption (reference group <1 cup). After adjustment for covariates, 3–4 cups of daily coffee were associated with lower PSMD (p = 0.028) and higher cortical thickness (p = 0.015) compared to <1 cup. Moreover, 1–2 cups per day was also associated with lower PSMD (p = 0.022). Associations with WMH load or other groups of coffee consumption were not significant (p > 0.05). The findings indicate that regular coffee consumption is positively associated with microstructural white matter integrity and cortical thickness. Further research is necessary to determine longitudinal effects of coffee on brain microstructure.
AB - Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegeneration, and microstructural integrity in 2316 participants in the population-based Hamburg City Health Study. Cortical thickness and white matter hyperintensity (WMH) load were measured on FLAIR and T1-weighted images. Microstructural white matter integrity was quantified as peak width of skeletonized mean diffusivity (PSMD) on diffusion-weighted MRI. Daily coffee consumption was assessed in five groups (<1 cup, 1–2 cups, 3–4 cups, 5–6 cups, >6 cups). In multiple linear regressions, we examined the association between brain MRI parameters and coffee consumption (reference group <1 cup). After adjustment for covariates, 3–4 cups of daily coffee were associated with lower PSMD (p = 0.028) and higher cortical thickness (p = 0.015) compared to <1 cup. Moreover, 1–2 cups per day was also associated with lower PSMD (p = 0.022). Associations with WMH load or other groups of coffee consumption were not significant (p > 0.05). The findings indicate that regular coffee consumption is positively associated with microstructural white matter integrity and cortical thickness. Further research is necessary to determine longitudinal effects of coffee on brain microstructure.
UR - https://www.mdpi.com/2072-6643/15/3/674
U2 - 10.3390/nu15030674
DO - 10.3390/nu15030674
M3 - SCORING: Journal article
C2 - 36771381
VL - 15
JO - NUTRIENTS
JF - NUTRIENTS
SN - 2072-6643
IS - 3
M1 - 674
ER -