Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study

TY - JOUR

T1 - Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study

AU - Mayer, Carola

AU - Nägele, Felix L.

AU - Petersen, Marvin

AU - Schell, Maximilian

AU - Aarabi, Ghazal

AU - Beikler, Thomas

AU - Borof, Katrin

AU - Frey, Benedikt M.

AU - Nikorowitsch, Julius

AU - Senftinger, Juliana

AU - Walther, Carolin

AU - Wenzel, Jan-Per

AU - Zyriax, Birgit-Christiane

AU - Cheng, Bastian

AU - Thomalla, Götz

PY - 2023/1/28

Y1 - 2023/1/28

N2 - Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegeneration, and microstructural integrity in 2316 participants in the population-based Hamburg City Health Study. Cortical thickness and white matter hyperintensity (WMH) load were measured on FLAIR and T1-weighted images. Microstructural white matter integrity was quantified as peak width of skeletonized mean diffusivity (PSMD) on diffusion-weighted MRI. Daily coffee consumption was assessed in five groups (<1 cup, 1–2 cups, 3–4 cups, 5–6 cups, >6 cups). In multiple linear regressions, we examined the association between brain MRI parameters and coffee consumption (reference group <1 cup). After adjustment for covariates, 3–4 cups of daily coffee were associated with lower PSMD (p = 0.028) and higher cortical thickness (p = 0.015) compared to <1 cup. Moreover, 1–2 cups per day was also associated with lower PSMD (p = 0.022). Associations with WMH load or other groups of coffee consumption were not significant (p > 0.05). The findings indicate that regular coffee consumption is positively associated with microstructural white matter integrity and cortical thickness. Further research is necessary to determine longitudinal effects of coffee on brain microstructure.

AB - Despite associations of regular coffee consumption with fewer neurodegenerative disorders, its association with microstructural brain alterations is unclear. To address this, we examined the association of coffee consumption with brain MRI parameters representing vascular brain damage, neurodegeneration, and microstructural integrity in 2316 participants in the population-based Hamburg City Health Study. Cortical thickness and white matter hyperintensity (WMH) load were measured on FLAIR and T1-weighted images. Microstructural white matter integrity was quantified as peak width of skeletonized mean diffusivity (PSMD) on diffusion-weighted MRI. Daily coffee consumption was assessed in five groups (<1 cup, 1–2 cups, 3–4 cups, 5–6 cups, >6 cups). In multiple linear regressions, we examined the association between brain MRI parameters and coffee consumption (reference group <1 cup). After adjustment for covariates, 3–4 cups of daily coffee were associated with lower PSMD (p = 0.028) and higher cortical thickness (p = 0.015) compared to <1 cup. Moreover, 1–2 cups per day was also associated with lower PSMD (p = 0.022). Associations with WMH load or other groups of coffee consumption were not significant (p > 0.05). The findings indicate that regular coffee consumption is positively associated with microstructural white matter integrity and cortical thickness. Further research is necessary to determine longitudinal effects of coffee on brain microstructure.

UR - https://www.mdpi.com/2072-6643/15/3/674

U2 - 10.3390/nu15030674

DO - 10.3390/nu15030674

M3 - SCORING: Journal article

C2 - 36771381

VL - 15

JO - NUTRIENTS

JF - NUTRIENTS

SN - 2072-6643

IS - 3

M1 - 674

ER -