Assessment of intracranial meningioma-associated calcifications using susceptibility-weighted MRI
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Assessment of intracranial meningioma-associated calcifications using susceptibility-weighted MRI. / Adams, Lisa C; Böker, Sarah M; Bender, Yvonne Y; Fallenberg, Eva M; Wagner, Moritz; Buchert, Ralph; Hamm, Bernd; Makowski, Marcus R.
in: J MAGN RESON IMAGING, Jahrgang 46, Nr. 4, 10.2017, S. 1177-1186.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Assessment of intracranial meningioma-associated calcifications using susceptibility-weighted MRI
AU - Adams, Lisa C
AU - Böker, Sarah M
AU - Bender, Yvonne Y
AU - Fallenberg, Eva M
AU - Wagner, Moritz
AU - Buchert, Ralph
AU - Hamm, Bernd
AU - Makowski, Marcus R
N1 - © 2017 International Society for Magnetic Resonance in Medicine.
PY - 2017/10
Y1 - 2017/10
N2 - PURPOSE: To determine the diagnostic accuracy of susceptibility-weighted MRI (SW-MRI) for the detection of intracranial meningioma-associated calcifications compared with standard MR sequences, using computed tomography (CT) as a reference standard.MATERIALS AND METHODS: 354 patients, who had received both a CT and a 1.5 Tesla clinical brain MRI with SW-MRI sequences between January 2014 and July 2016, were retrospectively evaluated and 316 patients were included. Calcification diameter was used to assess correlation between imaging modalities. Sensitivity and specificity as well as intra- and interobserver agreement were calculated for SW-MRI and standard MRI sequences when compared with reference standard CT.RESULTS: Fifty patients had positive findings for intracranial meningioma-associated calcifications on CT scans. SW-MRI reached a sensitivity of 94% (95% confidence interval [CI]: 83-99%) and a specificity of 95% (95% CI: 92-98%) for the detection of meningioma-associated calcifications, while standard MRI yielded a sensitivity of 64% (95% CI: 49-77%) and a specificity of 94% (95% CI: 90-96%). Diameter measurements between SW-MRI and CT showed a close correlation (R2 = 0.99; P < 0.001) with a slight overestimation of size, which, however, did not reach significance level (SW-MRI: 8.2 mm ± 7.1; CT: 6.8 mm ± 6.4; P = 0.29). Compared with standard MRI, SW-MRI showed a better interobserver agreement for size measurements of calcifications.CONCLUSION: SW-MRI enables a reliable detection of intracranial meningioma-associated calcifications by using CT as a reference and offers a higher diagnostic accuracy than standard MRI.LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1177-1186.
AB - PURPOSE: To determine the diagnostic accuracy of susceptibility-weighted MRI (SW-MRI) for the detection of intracranial meningioma-associated calcifications compared with standard MR sequences, using computed tomography (CT) as a reference standard.MATERIALS AND METHODS: 354 patients, who had received both a CT and a 1.5 Tesla clinical brain MRI with SW-MRI sequences between January 2014 and July 2016, were retrospectively evaluated and 316 patients were included. Calcification diameter was used to assess correlation between imaging modalities. Sensitivity and specificity as well as intra- and interobserver agreement were calculated for SW-MRI and standard MRI sequences when compared with reference standard CT.RESULTS: Fifty patients had positive findings for intracranial meningioma-associated calcifications on CT scans. SW-MRI reached a sensitivity of 94% (95% confidence interval [CI]: 83-99%) and a specificity of 95% (95% CI: 92-98%) for the detection of meningioma-associated calcifications, while standard MRI yielded a sensitivity of 64% (95% CI: 49-77%) and a specificity of 94% (95% CI: 90-96%). Diameter measurements between SW-MRI and CT showed a close correlation (R2 = 0.99; P < 0.001) with a slight overestimation of size, which, however, did not reach significance level (SW-MRI: 8.2 mm ± 7.1; CT: 6.8 mm ± 6.4; P = 0.29). Compared with standard MRI, SW-MRI showed a better interobserver agreement for size measurements of calcifications.CONCLUSION: SW-MRI enables a reliable detection of intracranial meningioma-associated calcifications by using CT as a reference and offers a higher diagnostic accuracy than standard MRI.LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1177-1186.
KW - Journal Article
U2 - 10.1002/jmri.25614
DO - 10.1002/jmri.25614
M3 - SCORING: Journal article
C2 - 28106942
VL - 46
SP - 1177
EP - 1186
JO - J MAGN RESON IMAGING
JF - J MAGN RESON IMAGING
SN - 1053-1807
IS - 4
ER -