Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection

Tobias Boettler; Upkar S Gill; Lena Allweiss; Teresa Pollicino; John E Tavis; Fabien Zoulim

doi:10.1016/j.jhepr.2022.100480

Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection

Standard

Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection. / Boettler, Tobias; Gill, Upkar S; Allweiss, Lena; Pollicino, Teresa; Tavis, John E; Zoulim, Fabien.

in: JHEP REP, Jahrgang 4, Nr. 6, 100480, 06.2022.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Boettler, T, Gill, US, Allweiss, L, Pollicino, T, Tavis, JE & Zoulim, F 2022, 'Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection', JHEP REP, Jg. 4, Nr. 6, 100480. https://doi.org/10.1016/j.jhepr.2022.100480

APA

Boettler, T., Gill, U. S., Allweiss, L., Pollicino, T., Tavis, J. E., & Zoulim, F. (2022). Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection. JHEP REP, 4(6), [100480]. https://doi.org/10.1016/j.jhepr.2022.100480

Vancouver

Boettler T, Gill US, Allweiss L, Pollicino T, Tavis JE, Zoulim F. Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection. JHEP REP. 2022 Jun;4(6). 100480. https://doi.org/10.1016/j.jhepr.2022.100480

Bibtex

@article{9b1911f988974162994bc4379f9fe237,

title = "Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection",

abstract = "Cure from chronic HBV infection is rare with current therapies. Basic research has helped to fundamentally improve our knowledge of the viral life cycle and virus-host interactions, and provided the basis for several novel drug classes that are currently being developed or are being tested in clinical trials. While these novel compounds targeting the viral life cycle or antiviral immune responses hold great promise, we are still lacking a comprehensive understanding of the immunological and virological processes that occur at the site of infection, the liver. At the International Liver Congress 2021 (ILC 2021), a research think tank on chronic HBV infection focused on mechanisms within the liver that facilitate persistent infection and looked at the research questions that need to be addressed to fill knowledge gaps and identify novel therapeutic strategies. Herein, we summarise the discussion by the think tank and identify the key basic research questions that must be addressed in order to develop more effective strategies for the functional cure of HBV infection.",

author = "Tobias Boettler and Gill, {Upkar S} and Lena Allweiss and Teresa Pollicino and Tavis, {John E} and Fabien Zoulim",

note = "{\textcopyright} 2022 The Author(s).",

year = "2022",

month = jun,

doi = "10.1016/j.jhepr.2022.100480",

language = "English",

volume = "4",

journal = "JHEP REP",

issn = "2589-5559",

publisher = "Elsevier",

number = "6",

}

RIS

TY - JOUR

T1 - Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection

AU - Boettler, Tobias

AU - Gill, Upkar S

AU - Allweiss, Lena

AU - Pollicino, Teresa

AU - Tavis, John E

AU - Zoulim, Fabien

PY - 2022/6

Y1 - 2022/6

N2 - Cure from chronic HBV infection is rare with current therapies. Basic research has helped to fundamentally improve our knowledge of the viral life cycle and virus-host interactions, and provided the basis for several novel drug classes that are currently being developed or are being tested in clinical trials. While these novel compounds targeting the viral life cycle or antiviral immune responses hold great promise, we are still lacking a comprehensive understanding of the immunological and virological processes that occur at the site of infection, the liver. At the International Liver Congress 2021 (ILC 2021), a research think tank on chronic HBV infection focused on mechanisms within the liver that facilitate persistent infection and looked at the research questions that need to be addressed to fill knowledge gaps and identify novel therapeutic strategies. Herein, we summarise the discussion by the think tank and identify the key basic research questions that must be addressed in order to develop more effective strategies for the functional cure of HBV infection.

AB - Cure from chronic HBV infection is rare with current therapies. Basic research has helped to fundamentally improve our knowledge of the viral life cycle and virus-host interactions, and provided the basis for several novel drug classes that are currently being developed or are being tested in clinical trials. While these novel compounds targeting the viral life cycle or antiviral immune responses hold great promise, we are still lacking a comprehensive understanding of the immunological and virological processes that occur at the site of infection, the liver. At the International Liver Congress 2021 (ILC 2021), a research think tank on chronic HBV infection focused on mechanisms within the liver that facilitate persistent infection and looked at the research questions that need to be addressed to fill knowledge gaps and identify novel therapeutic strategies. Herein, we summarise the discussion by the think tank and identify the key basic research questions that must be addressed in order to develop more effective strategies for the functional cure of HBV infection.

U2 - 10.1016/j.jhepr.2022.100480

DO - 10.1016/j.jhepr.2022.100480

M3 - SCORING: Review article

C2 - 35493765

VL - 4

JO - JHEP REP

JF - JHEP REP

SN - 2589-5559

IS - 6

M1 - 100480

ER -