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Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles.

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Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles. / Mouna, Mhamdi; Funk, Anneke; Hohenberg, Heinz; Will, Hans; Sirma, Hüseyin.

in: HEPATOLOGY, Jahrgang 46, Nr. 1, 1, 2007, S. 95-106.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mouna, M, Funk, A, Hohenberg, H, Will, H & Sirma, H 2007, 'Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles.', HEPATOLOGY, Jg. 46, Nr. 1, 1, S. 95-106. <http://www.ncbi.nlm.nih.gov/pubmed/17567837?dopt=Citation>

APA

Mouna, M., Funk, A., Hohenberg, H., Will, H., & Sirma, H. (2007). Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles. HEPATOLOGY, 46(1), 95-106. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17567837?dopt=Citation

Vancouver

Mouna M, Funk A, Hohenberg H, Will H, Sirma H. Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles. HEPATOLOGY. 2007;46(1):95-106. 1.

Bibtex

@article{a5bd883e0cbd4962aeba16b667f1dbe6,
title = "Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles.",
abstract = "Formation of enveloped viruses involves assembly and budding at cellular membranes. In this study, we elucidated the morphogenesis of hepadnaviruses on the ultrastructural and biochemical level using duck hepatitis B virus (DHBV) as a model system. Formation of virus progeny initiates at the endoplasmic reticulum (ER) and is conserved both in vitro and in vivo. The morphogenesis proceeds via membrane-surrounded vesicles containing both virions and subviral particles, indicating a common morphogenetic pathway. The virus particle-containing vesicles (VCVs) are generated and maintained by reorganization of endomembranes accompanied by a striking disorganization of the rough ER (rER). VCVs are novel organelles with unique identity and properties of ER, intermediate compartment, endosomes, and multivesicular bodies. VCVs are dynamic structures whose size and shape are regulated by both membrane fusion and fission. CONCLUSION: Our data indicate a strong reorganization of endomembranes during DHBV infection, resulting in the biogenesis of novel organelles serving as multifunctional platforms for assembly and budding of virus progeny.",
author = "Mhamdi Mouna and Anneke Funk and Heinz Hohenberg and Hans Will and H{\"u}seyin Sirma",
year = "2007",
language = "Deutsch",
volume = "46",
pages = "95--106",
journal = "HEPATOLOGY",
issn = "0270-9139",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles.

AU - Mouna, Mhamdi

AU - Funk, Anneke

AU - Hohenberg, Heinz

AU - Will, Hans

AU - Sirma, Hüseyin

PY - 2007

Y1 - 2007

N2 - Formation of enveloped viruses involves assembly and budding at cellular membranes. In this study, we elucidated the morphogenesis of hepadnaviruses on the ultrastructural and biochemical level using duck hepatitis B virus (DHBV) as a model system. Formation of virus progeny initiates at the endoplasmic reticulum (ER) and is conserved both in vitro and in vivo. The morphogenesis proceeds via membrane-surrounded vesicles containing both virions and subviral particles, indicating a common morphogenetic pathway. The virus particle-containing vesicles (VCVs) are generated and maintained by reorganization of endomembranes accompanied by a striking disorganization of the rough ER (rER). VCVs are novel organelles with unique identity and properties of ER, intermediate compartment, endosomes, and multivesicular bodies. VCVs are dynamic structures whose size and shape are regulated by both membrane fusion and fission. CONCLUSION: Our data indicate a strong reorganization of endomembranes during DHBV infection, resulting in the biogenesis of novel organelles serving as multifunctional platforms for assembly and budding of virus progeny.

AB - Formation of enveloped viruses involves assembly and budding at cellular membranes. In this study, we elucidated the morphogenesis of hepadnaviruses on the ultrastructural and biochemical level using duck hepatitis B virus (DHBV) as a model system. Formation of virus progeny initiates at the endoplasmic reticulum (ER) and is conserved both in vitro and in vivo. The morphogenesis proceeds via membrane-surrounded vesicles containing both virions and subviral particles, indicating a common morphogenetic pathway. The virus particle-containing vesicles (VCVs) are generated and maintained by reorganization of endomembranes accompanied by a striking disorganization of the rough ER (rER). VCVs are novel organelles with unique identity and properties of ER, intermediate compartment, endosomes, and multivesicular bodies. VCVs are dynamic structures whose size and shape are regulated by both membrane fusion and fission. CONCLUSION: Our data indicate a strong reorganization of endomembranes during DHBV infection, resulting in the biogenesis of novel organelles serving as multifunctional platforms for assembly and budding of virus progeny.

M3 - SCORING: Zeitschriftenaufsatz

VL - 46

SP - 95

EP - 106

JO - HEPATOLOGY

JF - HEPATOLOGY

SN - 0270-9139

IS - 1

M1 - 1

ER -