Assembly and biological role of podosomes and invadopodia.
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Assembly and biological role of podosomes and invadopodia. / Gimona, Mario; Buccione, Roberto; Courtneidge, Sara A; Linder, Stefan.
in: CURR OPIN CELL BIOL, Jahrgang 20, Nr. 2, 2, 2008, S. 235-241.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Assembly and biological role of podosomes and invadopodia.
AU - Gimona, Mario
AU - Buccione, Roberto
AU - Courtneidge, Sara A
AU - Linder, Stefan
PY - 2008
Y1 - 2008
N2 - Regulated tissue invasion via motile and lytic events is critical for physiological processes such as immune system function and inflammatory responses, wound healing, and organ development, but pathological subversion of this process drives tumour cell invasion and metastasis. Cell migration and invasion require the integration of several processes that include: first, the local modulation of cytoskeleton structure and contractile forces; second, the turnover of substrate adhesions and their associated microfilaments; and third, the generation of specialised, transient domains that mediate the protease-dependent focal degradation of the extracellular matrix. Recent work has re-discovered prominent actin-based cellular structures, termed invadopodia and podosomes, as unique structural and functional modules through which major invasive mechanisms are regulated. The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair.
AB - Regulated tissue invasion via motile and lytic events is critical for physiological processes such as immune system function and inflammatory responses, wound healing, and organ development, but pathological subversion of this process drives tumour cell invasion and metastasis. Cell migration and invasion require the integration of several processes that include: first, the local modulation of cytoskeleton structure and contractile forces; second, the turnover of substrate adhesions and their associated microfilaments; and third, the generation of specialised, transient domains that mediate the protease-dependent focal degradation of the extracellular matrix. Recent work has re-discovered prominent actin-based cellular structures, termed invadopodia and podosomes, as unique structural and functional modules through which major invasive mechanisms are regulated. The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair.
M3 - SCORING: Zeitschriftenaufsatz
VL - 20
SP - 235
EP - 241
IS - 2
M1 - 2
ER -
