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Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer

Standard

Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer. / Apostolova, Ivayla; Steffen, Ingo G; Wedel, Florian; Lougovski, Alexandr; Marnitz, Simone; Derlin, Thorsten; Amthauer, Holger; Buchert, Ralph; Hofheinz, Frank; Brenner, Winfried.

in: EUR RADIOL, Jahrgang 24, Nr. 9, 09.2014, S. 2077-87.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Apostolova, I, Steffen, IG, Wedel, F, Lougovski, A, Marnitz, S, Derlin, T, Amthauer, H, Buchert, R, Hofheinz, F & Brenner, W 2014, 'Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer', EUR RADIOL, Jg. 24, Nr. 9, S. 2077-87. https://doi.org/10.1007/s00330-014-3269-8

APA

Apostolova, I., Steffen, I. G., Wedel, F., Lougovski, A., Marnitz, S., Derlin, T., Amthauer, H., Buchert, R., Hofheinz, F., & Brenner, W. (2014). Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer. EUR RADIOL, 24(9), 2077-87. https://doi.org/10.1007/s00330-014-3269-8

Vancouver

Apostolova I, Steffen IG, Wedel F, Lougovski A, Marnitz S, Derlin T et al. Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer. EUR RADIOL. 2014 Sep;24(9):2077-87. https://doi.org/10.1007/s00330-014-3269-8

Bibtex

@article{ae35a20fcebb485fa31e984aaeeed512,
title = "Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer",
abstract = "OBJECTIVE: To propose a novel measure, namely the 'asphericity' (ASP), of spatial irregularity of FDG uptake in the primary tumour as a prognostic marker in head-and-neck cancer.METHODS: PET/CT was performed in 52 patients (first presentation, n = 36; recurrence, n = 16). The primary tumour was segmented based on thresholding at the volume-reproducible intensity threshold after subtraction of the local background. ASP was used to characterise the deviation of the tumour's shape from sphere symmetry. Tumour stage, tumour localisation, lymph node metastases, distant metastases, SUVmax, SUVmean, metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were also considered. The association of overall (OAS) and progression-free survival (PFS) with these parameters was analysed.RESULTS: Cox regression revealed high SUVmax [hazard ratio (HR) = 4.4/7.4], MTV (HR = 4.6/5.7), TLG (HR = 4.8/8.9) and ASP (HR = 7.8/7.4) as significant predictors with respect to PFS/OAS in case of first tumour manifestation. The combination of high MTV and ASP showed very high HRs of 22.7 for PFS and 13.2 for OAS. In case of recurrence, MTV (HR = 3.7) and the combination of MTV/ASP (HR = 4.2) were significant predictors of PFS.CONCLUSIONS: ASP of pretherapeutic FDG uptake in the primary tumour improves the prediction of tumour progression in head-and-neck cancer at first tumour presentation.KEY POINTS: Asphericity (ASP) characterises the spatial heterogeneity of FDG uptake in tumours. ASP is a promising prognostic parameter in head-and-neck cancer. ASP is useful for identification of high-risk patients with head-and-neck cancer.",
keywords = "Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Follow-Up Studies, Germany, Head and Neck Neoplasms, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Prevalence, Prognosis, Reproducibility of Results, Retrospective Studies, Survival Rate, Tomography, X-Ray Computed, Tumor Burden, Journal Article",
author = "Ivayla Apostolova and Steffen, {Ingo G} and Florian Wedel and Alexandr Lougovski and Simone Marnitz and Thorsten Derlin and Holger Amthauer and Ralph Buchert and Frank Hofheinz and Winfried Brenner",
year = "2014",
month = sep,
doi = "10.1007/s00330-014-3269-8",
language = "English",
volume = "24",
pages = "2077--87",
journal = "EUR RADIOL",
issn = "0938-7994",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer

AU - Apostolova, Ivayla

AU - Steffen, Ingo G

AU - Wedel, Florian

AU - Lougovski, Alexandr

AU - Marnitz, Simone

AU - Derlin, Thorsten

AU - Amthauer, Holger

AU - Buchert, Ralph

AU - Hofheinz, Frank

AU - Brenner, Winfried

PY - 2014/9

Y1 - 2014/9

N2 - OBJECTIVE: To propose a novel measure, namely the 'asphericity' (ASP), of spatial irregularity of FDG uptake in the primary tumour as a prognostic marker in head-and-neck cancer.METHODS: PET/CT was performed in 52 patients (first presentation, n = 36; recurrence, n = 16). The primary tumour was segmented based on thresholding at the volume-reproducible intensity threshold after subtraction of the local background. ASP was used to characterise the deviation of the tumour's shape from sphere symmetry. Tumour stage, tumour localisation, lymph node metastases, distant metastases, SUVmax, SUVmean, metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were also considered. The association of overall (OAS) and progression-free survival (PFS) with these parameters was analysed.RESULTS: Cox regression revealed high SUVmax [hazard ratio (HR) = 4.4/7.4], MTV (HR = 4.6/5.7), TLG (HR = 4.8/8.9) and ASP (HR = 7.8/7.4) as significant predictors with respect to PFS/OAS in case of first tumour manifestation. The combination of high MTV and ASP showed very high HRs of 22.7 for PFS and 13.2 for OAS. In case of recurrence, MTV (HR = 3.7) and the combination of MTV/ASP (HR = 4.2) were significant predictors of PFS.CONCLUSIONS: ASP of pretherapeutic FDG uptake in the primary tumour improves the prediction of tumour progression in head-and-neck cancer at first tumour presentation.KEY POINTS: Asphericity (ASP) characterises the spatial heterogeneity of FDG uptake in tumours. ASP is a promising prognostic parameter in head-and-neck cancer. ASP is useful for identification of high-risk patients with head-and-neck cancer.

AB - OBJECTIVE: To propose a novel measure, namely the 'asphericity' (ASP), of spatial irregularity of FDG uptake in the primary tumour as a prognostic marker in head-and-neck cancer.METHODS: PET/CT was performed in 52 patients (first presentation, n = 36; recurrence, n = 16). The primary tumour was segmented based on thresholding at the volume-reproducible intensity threshold after subtraction of the local background. ASP was used to characterise the deviation of the tumour's shape from sphere symmetry. Tumour stage, tumour localisation, lymph node metastases, distant metastases, SUVmax, SUVmean, metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were also considered. The association of overall (OAS) and progression-free survival (PFS) with these parameters was analysed.RESULTS: Cox regression revealed high SUVmax [hazard ratio (HR) = 4.4/7.4], MTV (HR = 4.6/5.7), TLG (HR = 4.8/8.9) and ASP (HR = 7.8/7.4) as significant predictors with respect to PFS/OAS in case of first tumour manifestation. The combination of high MTV and ASP showed very high HRs of 22.7 for PFS and 13.2 for OAS. In case of recurrence, MTV (HR = 3.7) and the combination of MTV/ASP (HR = 4.2) were significant predictors of PFS.CONCLUSIONS: ASP of pretherapeutic FDG uptake in the primary tumour improves the prediction of tumour progression in head-and-neck cancer at first tumour presentation.KEY POINTS: Asphericity (ASP) characterises the spatial heterogeneity of FDG uptake in tumours. ASP is a promising prognostic parameter in head-and-neck cancer. ASP is useful for identification of high-risk patients with head-and-neck cancer.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Disease-Free Survival

KW - Female

KW - Follow-Up Studies

KW - Germany

KW - Head and Neck Neoplasms

KW - Humans

KW - Imaging, Three-Dimensional

KW - Male

KW - Middle Aged

KW - Multimodal Imaging

KW - Positron-Emission Tomography

KW - Prevalence

KW - Prognosis

KW - Reproducibility of Results

KW - Retrospective Studies

KW - Survival Rate

KW - Tomography, X-Ray Computed

KW - Tumor Burden

KW - Journal Article

U2 - 10.1007/s00330-014-3269-8

DO - 10.1007/s00330-014-3269-8

M3 - SCORING: Journal article

C2 - 24965509

VL - 24

SP - 2077

EP - 2087

JO - EUR RADIOL

JF - EUR RADIOL

SN - 0938-7994

IS - 9

ER -