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Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation

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Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation. / Christ, Torsten; Rozmaritsa, Nadiia; Engel, Andreas; Berk, Emanuel; Knaut, Michael; Metzner, Katharina; Canteras, Manuel; Ravens, Ursula; Kaumann, Alberto .

in: P NATL ACAD SCI USA, Jahrgang 111, Nr. 30, 29.07.2014, S. 11193-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Christ, T, Rozmaritsa, N, Engel, A, Berk, E, Knaut, M, Metzner, K, Canteras, M, Ravens, U & Kaumann, A 2014, 'Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation', P NATL ACAD SCI USA, Jg. 111, Nr. 30, S. 11193-8. https://doi.org/10.1073/pnas.1324132111

APA

Christ, T., Rozmaritsa, N., Engel, A., Berk, E., Knaut, M., Metzner, K., Canteras, M., Ravens, U., & Kaumann, A. (2014). Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation. P NATL ACAD SCI USA, 111(30), 11193-8. https://doi.org/10.1073/pnas.1324132111

Vancouver

Christ T, Rozmaritsa N, Engel A, Berk E, Knaut M, Metzner K et al. Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation. P NATL ACAD SCI USA. 2014 Jul 29;111(30):11193-8. https://doi.org/10.1073/pnas.1324132111

Bibtex

@article{1b4d1a81b6364d96ab6b9b04e26b3dc9,
title = "Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation",
abstract = "Atrial fibrillation (AF) is the most common heart rhythm disorder. Transient postoperative AF can be elicited by high sympathetic nervous system activity. Catecholamines and serotonin cause arrhythmias in atrial trabeculae from patients with sinus rhythm (SR), but whether these arrhythmias occur in patients with chronic AF is unknown. We compared the incidence of arrhythmic contractions caused by norepinephrine, epinephrine, serotonin, and forskolin in atrial trabeculae from patients with SR and patients with AF. In the patients with AF, arrhythmias were markedly reduced for the agonists and abolished for forskolin, whereas maximum inotropic responses were markedly blunted only for serotonin. Serotonin and forskolin produced spontaneous diastolic Ca(2+) releases in atrial myocytes from the patients with SR that were abolished or reduced in myocytes from the patients with AF. For matching L-type Ca(2+)-current (ICa,L) responses, serotonin required and produced ∼ 100-fold less cAMP/PKA at the Ca(2+) channel domain compared with the catecholamines and forskolin. Norepinephrine-evoked ICa,L responses were decreased by inhibition of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in myocytes from patients with SR, but not in those from patients with AF. Agonist-evoked phosphorylation by CaMKII at phospholamban (Thr-17), but not of ryanodine2 (Ser-2814), was reduced in trabeculae from patients with AF. The decreased CaMKII activity may contribute to the blunting of agonist-evoked arrhythmias in the atrial myocardium of patients with AF.",
keywords = "Atrial Fibrillation, Calcium, Calcium Channels, L-Type, Calcium-Binding Proteins, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cardiotonic Agents, Catecholamines, Chronic Disease, Colforsin, Cyclic AMP, Female, Heart Atria, Humans, Male, Myocardial Contraction, Phosphorylation, Ryanodine, Serotonin, Serotonin Receptor Agonists",
author = "Torsten Christ and Nadiia Rozmaritsa and Andreas Engel and Emanuel Berk and Michael Knaut and Katharina Metzner and Manuel Canteras and Ursula Ravens and Alberto Kaumann",
year = "2014",
month = jul,
day = "29",
doi = "10.1073/pnas.1324132111",
language = "English",
volume = "111",
pages = "11193--8",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "30",

}

RIS

TY - JOUR

T1 - Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation

AU - Christ, Torsten

AU - Rozmaritsa, Nadiia

AU - Engel, Andreas

AU - Berk, Emanuel

AU - Knaut, Michael

AU - Metzner, Katharina

AU - Canteras, Manuel

AU - Ravens, Ursula

AU - Kaumann, Alberto

PY - 2014/7/29

Y1 - 2014/7/29

N2 - Atrial fibrillation (AF) is the most common heart rhythm disorder. Transient postoperative AF can be elicited by high sympathetic nervous system activity. Catecholamines and serotonin cause arrhythmias in atrial trabeculae from patients with sinus rhythm (SR), but whether these arrhythmias occur in patients with chronic AF is unknown. We compared the incidence of arrhythmic contractions caused by norepinephrine, epinephrine, serotonin, and forskolin in atrial trabeculae from patients with SR and patients with AF. In the patients with AF, arrhythmias were markedly reduced for the agonists and abolished for forskolin, whereas maximum inotropic responses were markedly blunted only for serotonin. Serotonin and forskolin produced spontaneous diastolic Ca(2+) releases in atrial myocytes from the patients with SR that were abolished or reduced in myocytes from the patients with AF. For matching L-type Ca(2+)-current (ICa,L) responses, serotonin required and produced ∼ 100-fold less cAMP/PKA at the Ca(2+) channel domain compared with the catecholamines and forskolin. Norepinephrine-evoked ICa,L responses were decreased by inhibition of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in myocytes from patients with SR, but not in those from patients with AF. Agonist-evoked phosphorylation by CaMKII at phospholamban (Thr-17), but not of ryanodine2 (Ser-2814), was reduced in trabeculae from patients with AF. The decreased CaMKII activity may contribute to the blunting of agonist-evoked arrhythmias in the atrial myocardium of patients with AF.

AB - Atrial fibrillation (AF) is the most common heart rhythm disorder. Transient postoperative AF can be elicited by high sympathetic nervous system activity. Catecholamines and serotonin cause arrhythmias in atrial trabeculae from patients with sinus rhythm (SR), but whether these arrhythmias occur in patients with chronic AF is unknown. We compared the incidence of arrhythmic contractions caused by norepinephrine, epinephrine, serotonin, and forskolin in atrial trabeculae from patients with SR and patients with AF. In the patients with AF, arrhythmias were markedly reduced for the agonists and abolished for forskolin, whereas maximum inotropic responses were markedly blunted only for serotonin. Serotonin and forskolin produced spontaneous diastolic Ca(2+) releases in atrial myocytes from the patients with SR that were abolished or reduced in myocytes from the patients with AF. For matching L-type Ca(2+)-current (ICa,L) responses, serotonin required and produced ∼ 100-fold less cAMP/PKA at the Ca(2+) channel domain compared with the catecholamines and forskolin. Norepinephrine-evoked ICa,L responses were decreased by inhibition of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in myocytes from patients with SR, but not in those from patients with AF. Agonist-evoked phosphorylation by CaMKII at phospholamban (Thr-17), but not of ryanodine2 (Ser-2814), was reduced in trabeculae from patients with AF. The decreased CaMKII activity may contribute to the blunting of agonist-evoked arrhythmias in the atrial myocardium of patients with AF.

KW - Atrial Fibrillation

KW - Calcium

KW - Calcium Channels, L-Type

KW - Calcium-Binding Proteins

KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2

KW - Cardiotonic Agents

KW - Catecholamines

KW - Chronic Disease

KW - Colforsin

KW - Cyclic AMP

KW - Female

KW - Heart Atria

KW - Humans

KW - Male

KW - Myocardial Contraction

KW - Phosphorylation

KW - Ryanodine

KW - Serotonin

KW - Serotonin Receptor Agonists

U2 - 10.1073/pnas.1324132111

DO - 10.1073/pnas.1324132111

M3 - SCORING: Journal article

C2 - 25024212

VL - 111

SP - 11193

EP - 11198

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 30

ER -