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Aromatase inhibition abolishes LTP generation in female but not in male mice.

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Aromatase inhibition abolishes LTP generation in female but not in male mice. / Vierk, Ricardo; Glassmeier, Günter; Zhou, Lepu; Brandt, Nicola; Fester, Lars; Dudzinski, Danuta; Wilkars, Wiebke; Bender, Roland; Lewerenz, Martha; Gloger, Simon; Graser, Lucas; Schwarz, Jürgen; Rune, Gabriele M.

in: J NEUROSCI, Jahrgang 32, Nr. 24, 24, 2012, S. 8116-8126.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Vierk, R, Glassmeier, G, Zhou, L, Brandt, N, Fester, L, Dudzinski, D, Wilkars, W, Bender, R, Lewerenz, M, Gloger, S, Graser, L, Schwarz, J & Rune, GM 2012, 'Aromatase inhibition abolishes LTP generation in female but not in male mice.', J NEUROSCI, Jg. 32, Nr. 24, 24, S. 8116-8126. <http://www.ncbi.nlm.nih.gov/pubmed/22699893?dopt=Citation>

APA

Vierk, R., Glassmeier, G., Zhou, L., Brandt, N., Fester, L., Dudzinski, D., Wilkars, W., Bender, R., Lewerenz, M., Gloger, S., Graser, L., Schwarz, J., & Rune, G. M. (2012). Aromatase inhibition abolishes LTP generation in female but not in male mice. J NEUROSCI, 32(24), 8116-8126. [24]. http://www.ncbi.nlm.nih.gov/pubmed/22699893?dopt=Citation

Vancouver

Vierk R, Glassmeier G, Zhou L, Brandt N, Fester L, Dudzinski D et al. Aromatase inhibition abolishes LTP generation in female but not in male mice. J NEUROSCI. 2012;32(24):8116-8126. 24.

Bibtex

@article{d9184303d9df432a9e7e0cdb26c20e19,
title = "Aromatase inhibition abolishes LTP generation in female but not in male mice.",
abstract = "Inhibitors of aromatase, the final enzyme of estradiol synthesis, are suspected of inducing memory deficits in women. In previous experiments, we found hippocampal spine synapse loss in female mice that had been treated with letrozole, a potent aromatase inhibitor. In this study, we therefore focused on the effects of letrozole on long-term potentiation (LTP), which is an electrophysiological parameter of memory and is known to induce spines, and on phosphorylation of cofilin, which stabilizes the spine cytoskeleton and is required for LTP in mice. In acute slices of letrozole-treated female mice with reduced estradiol serum concentrations, impairment of LTP started as early as after 6 h of treatment and progressed further, together with dephosphorylation of cofilin in the same slices. Theta-burst stimulation failed to induce LTP after 1 week of treatment. Impairment of LTP was followed by spine and spine synapse loss. The effects were confirmed in vitro by using hippocampal slice cultures of female mice. The sequence of effects in response to letrozole were similar in ovariectomized female and male mice, with, however, differences as to the degree of downregulation. Our data strongly suggest that impairment of LTP, followed by loss of mushroom spines and spine synapses in females, may have implications for memory deficits in women treated with letrozole.",
keywords = "Animals, Male, Female, Cells, Cultured, Mice, Mice, Inbred C57BL, Rats, Rats, Wistar, Estradiol/blood, Aromatase/*physiology, Aromatase Inhibitors/*pharmacology, Cofilin 1/metabolism, Dendritic Spines/drug effects/ultrastructure, Excitatory Postsynaptic Potentials/drug effects/physiology, Hippocampus/cytology/drug effects/physiology, Long-Term Potentiation/drug effects/*physiology, Nitriles/*pharmacology, *Sex Characteristics, Synapses/drug effects/physiology/ultrastructure, Triazoles/*pharmacology, Animals, Male, Female, Cells, Cultured, Mice, Mice, Inbred C57BL, Rats, Rats, Wistar, Estradiol/blood, Aromatase/*physiology, Aromatase Inhibitors/*pharmacology, Cofilin 1/metabolism, Dendritic Spines/drug effects/ultrastructure, Excitatory Postsynaptic Potentials/drug effects/physiology, Hippocampus/cytology/drug effects/physiology, Long-Term Potentiation/drug effects/*physiology, Nitriles/*pharmacology, *Sex Characteristics, Synapses/drug effects/physiology/ultrastructure, Triazoles/*pharmacology",
author = "Ricardo Vierk and G{\"u}nter Glassmeier and Lepu Zhou and Nicola Brandt and Lars Fester and Danuta Dudzinski and Wiebke Wilkars and Roland Bender and Martha Lewerenz and Simon Gloger and Lucas Graser and J{\"u}rgen Schwarz and Rune, {Gabriele M.}",
year = "2012",
language = "English",
volume = "32",
pages = "8116--8126",
journal = "J NEUROSCI",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "24",

}

RIS

TY - JOUR

T1 - Aromatase inhibition abolishes LTP generation in female but not in male mice.

AU - Vierk, Ricardo

AU - Glassmeier, Günter

AU - Zhou, Lepu

AU - Brandt, Nicola

AU - Fester, Lars

AU - Dudzinski, Danuta

AU - Wilkars, Wiebke

AU - Bender, Roland

AU - Lewerenz, Martha

AU - Gloger, Simon

AU - Graser, Lucas

AU - Schwarz, Jürgen

AU - Rune, Gabriele M.

PY - 2012

Y1 - 2012

N2 - Inhibitors of aromatase, the final enzyme of estradiol synthesis, are suspected of inducing memory deficits in women. In previous experiments, we found hippocampal spine synapse loss in female mice that had been treated with letrozole, a potent aromatase inhibitor. In this study, we therefore focused on the effects of letrozole on long-term potentiation (LTP), which is an electrophysiological parameter of memory and is known to induce spines, and on phosphorylation of cofilin, which stabilizes the spine cytoskeleton and is required for LTP in mice. In acute slices of letrozole-treated female mice with reduced estradiol serum concentrations, impairment of LTP started as early as after 6 h of treatment and progressed further, together with dephosphorylation of cofilin in the same slices. Theta-burst stimulation failed to induce LTP after 1 week of treatment. Impairment of LTP was followed by spine and spine synapse loss. The effects were confirmed in vitro by using hippocampal slice cultures of female mice. The sequence of effects in response to letrozole were similar in ovariectomized female and male mice, with, however, differences as to the degree of downregulation. Our data strongly suggest that impairment of LTP, followed by loss of mushroom spines and spine synapses in females, may have implications for memory deficits in women treated with letrozole.

AB - Inhibitors of aromatase, the final enzyme of estradiol synthesis, are suspected of inducing memory deficits in women. In previous experiments, we found hippocampal spine synapse loss in female mice that had been treated with letrozole, a potent aromatase inhibitor. In this study, we therefore focused on the effects of letrozole on long-term potentiation (LTP), which is an electrophysiological parameter of memory and is known to induce spines, and on phosphorylation of cofilin, which stabilizes the spine cytoskeleton and is required for LTP in mice. In acute slices of letrozole-treated female mice with reduced estradiol serum concentrations, impairment of LTP started as early as after 6 h of treatment and progressed further, together with dephosphorylation of cofilin in the same slices. Theta-burst stimulation failed to induce LTP after 1 week of treatment. Impairment of LTP was followed by spine and spine synapse loss. The effects were confirmed in vitro by using hippocampal slice cultures of female mice. The sequence of effects in response to letrozole were similar in ovariectomized female and male mice, with, however, differences as to the degree of downregulation. Our data strongly suggest that impairment of LTP, followed by loss of mushroom spines and spine synapses in females, may have implications for memory deficits in women treated with letrozole.

KW - Animals

KW - Male

KW - Female

KW - Cells, Cultured

KW - Mice

KW - Mice, Inbred C57BL

KW - Rats

KW - Rats, Wistar

KW - Estradiol/blood

KW - Aromatase/physiology

KW - Aromatase Inhibitors/pharmacology

KW - Cofilin 1/metabolism

KW - Dendritic Spines/drug effects/ultrastructure

KW - Excitatory Postsynaptic Potentials/drug effects/physiology

KW - Hippocampus/cytology/drug effects/physiology

KW - Long-Term Potentiation/drug effects/physiology

KW - Nitriles/pharmacology

KW - Sex Characteristics

KW - Synapses/drug effects/physiology/ultrastructure

KW - Triazoles/pharmacology

KW - Animals

KW - Male

KW - Female

KW - Cells, Cultured

KW - Mice

KW - Mice, Inbred C57BL

KW - Rats

KW - Rats, Wistar

KW - Estradiol/blood

KW - Aromatase/physiology

KW - Aromatase Inhibitors/pharmacology

KW - Cofilin 1/metabolism

KW - Dendritic Spines/drug effects/ultrastructure

KW - Excitatory Postsynaptic Potentials/drug effects/physiology

KW - Hippocampus/cytology/drug effects/physiology

KW - Long-Term Potentiation/drug effects/physiology

KW - Nitriles/pharmacology

KW - Sex Characteristics

KW - Synapses/drug effects/physiology/ultrastructure

KW - Triazoles/pharmacology

M3 - SCORING: Journal article

VL - 32

SP - 8116

EP - 8126

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 24

M1 - 24

ER -