Application of testosterone accelerates oligodendrocyte maturation in brains of zebra finches
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Application of testosterone accelerates oligodendrocyte maturation in brains of zebra finches. / Kafitz, K W; Herth, G; Bartsch, U; Güttinger, H R; Schachner, M.
in: NEUROREPORT, Jahrgang 3, Nr. 4, 04.1992, S. 315-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Application of testosterone accelerates oligodendrocyte maturation in brains of zebra finches
AU - Kafitz, K W
AU - Herth, G
AU - Bartsch, U
AU - Güttinger, H R
AU - Schachner, M
PY - 1992/4
Y1 - 1992/4
N2 - The effects of exogenously applied hormones on glial cell maturation of telencephalic song motor centers, midbrain and cerebellar structures was studied in juvenile male zebra finches. Testosterone was administered and the development of oligodendrocytes was studied using immunochemistry and computer aided image analysis on silver impregnated brain sections. A testosterone induced acceleration of oligodendrocyte maturation could be detected in several brain areas by using the monoclonal antibody O 10 recognizing an oligodendrocyte-specific cell surface antigen and by the silver impregnation for myelin. The increase in myelin density was higher in the testosterone treated animals than in the control animals in the forebrain and in the cerebellum, whereas two regions in the midbrain showed no difference between treated and controls.
AB - The effects of exogenously applied hormones on glial cell maturation of telencephalic song motor centers, midbrain and cerebellar structures was studied in juvenile male zebra finches. Testosterone was administered and the development of oligodendrocytes was studied using immunochemistry and computer aided image analysis on silver impregnated brain sections. A testosterone induced acceleration of oligodendrocyte maturation could be detected in several brain areas by using the monoclonal antibody O 10 recognizing an oligodendrocyte-specific cell surface antigen and by the silver impregnation for myelin. The increase in myelin density was higher in the testosterone treated animals than in the control animals in the forebrain and in the cerebellum, whereas two regions in the midbrain showed no difference between treated and controls.
KW - Aging
KW - Animals
KW - Birds
KW - Brain
KW - Male
KW - Myelin Sheath
KW - Oligodendroglia
KW - Organ Specificity
KW - Testosterone
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - SCORING: Journal article
C2 - 1515589
VL - 3
SP - 315
EP - 318
JO - NEUROREPORT
JF - NEUROREPORT
SN - 0959-4965
IS - 4
ER -