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Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease

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Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease. / Mengel, David; Dams, Judith; Ziemek, Jannis; Becker, Julian; Balzer-Geldsetzer, Monika; Hilker, Rüdiger; Baudrexel, Simon; Kalbe, Elke; Schmidt, Nele; Witt, Karsten; Liepelt-Scarfone, Inga; Gräber, Susanne; Petrelli, Annette; Neuser, Petra; Schulte, Claudia; Linse, Katharina; Storch, Alexander; Wittchen, Hans-Ulrich; Riedel, Oliver; Mollenhauer, Brit; Ebentheuer, Jens; Trenkwalder, Claudia; Klockgether, Thomas; Spottke, Annika; Wüllner, Ullrich; Schulz, Jörg B; Reetz, Kathrin; Heber, Ines Ann; Ramirez, Alfredo; Dodel, Richard.

in: PARKINSONISM RELAT D, Jahrgang 29, 08.2016, S. 112-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mengel, D, Dams, J, Ziemek, J, Becker, J, Balzer-Geldsetzer, M, Hilker, R, Baudrexel, S, Kalbe, E, Schmidt, N, Witt, K, Liepelt-Scarfone, I, Gräber, S, Petrelli, A, Neuser, P, Schulte, C, Linse, K, Storch, A, Wittchen, H-U, Riedel, O, Mollenhauer, B, Ebentheuer, J, Trenkwalder, C, Klockgether, T, Spottke, A, Wüllner, U, Schulz, JB, Reetz, K, Heber, IA, Ramirez, A & Dodel, R 2016, 'Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease', PARKINSONISM RELAT D, Jg. 29, S. 112-6. https://doi.org/10.1016/j.parkreldis.2016.04.013

APA

Mengel, D., Dams, J., Ziemek, J., Becker, J., Balzer-Geldsetzer, M., Hilker, R., Baudrexel, S., Kalbe, E., Schmidt, N., Witt, K., Liepelt-Scarfone, I., Gräber, S., Petrelli, A., Neuser, P., Schulte, C., Linse, K., Storch, A., Wittchen, H-U., Riedel, O., ... Dodel, R. (2016). Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease. PARKINSONISM RELAT D, 29, 112-6. https://doi.org/10.1016/j.parkreldis.2016.04.013

Vancouver

Mengel D, Dams J, Ziemek J, Becker J, Balzer-Geldsetzer M, Hilker R et al. Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease. PARKINSONISM RELAT D. 2016 Aug;29:112-6. https://doi.org/10.1016/j.parkreldis.2016.04.013

Bibtex

@article{150cb729cbd24d8da06142dc304205c3,
title = "Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease",
abstract = "INTRODUCTION: Cognitive impairment is a common and disabling non-motor symptom in Parkinson's disease (PD). The apolipoprotein E (APOE) allele ε4 is a known risk factor for Alzheimer's disease and has also been suggested to be a risk factor for dementia in PD and even a predictor of impairment in certain cognitive domains.METHODS: A total of 447 PD patients (PD patients without cognitive impairment: n = 187; PD patients with mild cognitive impairment: n = 188; PD patients with dementia: n = 72) were included from an ongoing observational German multicenter cohort study (LANDSCAPE study). All patients underwent an extensive neuropsychological test battery, including assessments of memory, visuospatial functioning, attention, language, and executive function. APOE genotype was determined by an allelic discrimination assay. Linear regression analysis was used to explore the associations between APOE-ε4 and cognitive performance.RESULTS: The APOE-ε4 allele was not associated with a diagnosis of cognitive impairment in PD (PD with mild cognitive impairment and PD with dementia) or with deficits in specific neuropsychological domains in our study cohort.CONCLUSION: Our data question the relevance of the APOE-ε4 allele as a predictor of cognitive impairment in PD.",
keywords = "Journal Article",
author = "David Mengel and Judith Dams and Jannis Ziemek and Julian Becker and Monika Balzer-Geldsetzer and R{\"u}diger Hilker and Simon Baudrexel and Elke Kalbe and Nele Schmidt and Karsten Witt and Inga Liepelt-Scarfone and Susanne Gr{\"a}ber and Annette Petrelli and Petra Neuser and Claudia Schulte and Katharina Linse and Alexander Storch and Hans-Ulrich Wittchen and Oliver Riedel and Brit Mollenhauer and Jens Ebentheuer and Claudia Trenkwalder and Thomas Klockgether and Annika Spottke and Ullrich W{\"u}llner and Schulz, {J{\"o}rg B} and Kathrin Reetz and Heber, {Ines Ann} and Alfredo Ramirez and Richard Dodel",
note = "Copyright {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
month = aug,
doi = "10.1016/j.parkreldis.2016.04.013",
language = "English",
volume = "29",
pages = "112--6",
journal = "PARKINSONISM RELAT D",
issn = "1353-8020",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease

AU - Mengel, David

AU - Dams, Judith

AU - Ziemek, Jannis

AU - Becker, Julian

AU - Balzer-Geldsetzer, Monika

AU - Hilker, Rüdiger

AU - Baudrexel, Simon

AU - Kalbe, Elke

AU - Schmidt, Nele

AU - Witt, Karsten

AU - Liepelt-Scarfone, Inga

AU - Gräber, Susanne

AU - Petrelli, Annette

AU - Neuser, Petra

AU - Schulte, Claudia

AU - Linse, Katharina

AU - Storch, Alexander

AU - Wittchen, Hans-Ulrich

AU - Riedel, Oliver

AU - Mollenhauer, Brit

AU - Ebentheuer, Jens

AU - Trenkwalder, Claudia

AU - Klockgether, Thomas

AU - Spottke, Annika

AU - Wüllner, Ullrich

AU - Schulz, Jörg B

AU - Reetz, Kathrin

AU - Heber, Ines Ann

AU - Ramirez, Alfredo

AU - Dodel, Richard

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/8

Y1 - 2016/8

N2 - INTRODUCTION: Cognitive impairment is a common and disabling non-motor symptom in Parkinson's disease (PD). The apolipoprotein E (APOE) allele ε4 is a known risk factor for Alzheimer's disease and has also been suggested to be a risk factor for dementia in PD and even a predictor of impairment in certain cognitive domains.METHODS: A total of 447 PD patients (PD patients without cognitive impairment: n = 187; PD patients with mild cognitive impairment: n = 188; PD patients with dementia: n = 72) were included from an ongoing observational German multicenter cohort study (LANDSCAPE study). All patients underwent an extensive neuropsychological test battery, including assessments of memory, visuospatial functioning, attention, language, and executive function. APOE genotype was determined by an allelic discrimination assay. Linear regression analysis was used to explore the associations between APOE-ε4 and cognitive performance.RESULTS: The APOE-ε4 allele was not associated with a diagnosis of cognitive impairment in PD (PD with mild cognitive impairment and PD with dementia) or with deficits in specific neuropsychological domains in our study cohort.CONCLUSION: Our data question the relevance of the APOE-ε4 allele as a predictor of cognitive impairment in PD.

AB - INTRODUCTION: Cognitive impairment is a common and disabling non-motor symptom in Parkinson's disease (PD). The apolipoprotein E (APOE) allele ε4 is a known risk factor for Alzheimer's disease and has also been suggested to be a risk factor for dementia in PD and even a predictor of impairment in certain cognitive domains.METHODS: A total of 447 PD patients (PD patients without cognitive impairment: n = 187; PD patients with mild cognitive impairment: n = 188; PD patients with dementia: n = 72) were included from an ongoing observational German multicenter cohort study (LANDSCAPE study). All patients underwent an extensive neuropsychological test battery, including assessments of memory, visuospatial functioning, attention, language, and executive function. APOE genotype was determined by an allelic discrimination assay. Linear regression analysis was used to explore the associations between APOE-ε4 and cognitive performance.RESULTS: The APOE-ε4 allele was not associated with a diagnosis of cognitive impairment in PD (PD with mild cognitive impairment and PD with dementia) or with deficits in specific neuropsychological domains in our study cohort.CONCLUSION: Our data question the relevance of the APOE-ε4 allele as a predictor of cognitive impairment in PD.

KW - Journal Article

U2 - 10.1016/j.parkreldis.2016.04.013

DO - 10.1016/j.parkreldis.2016.04.013

M3 - SCORING: Journal article

C2 - 27321987

VL - 29

SP - 112

EP - 116

JO - PARKINSONISM RELAT D

JF - PARKINSONISM RELAT D

SN - 1353-8020

ER -