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Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease

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Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease. / Chen, M; Arcari, L; Engel, J; Freiwald, T; Platschek, S; Zhou, H; Zainal, H; Buettner, S; Zeiher, AM; Geiger, H; Hauser, I; Nagel, E; Puntmann, VO.

in: IJC HEART VASC, Jahrgang 24, 100389, 06.2019.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Chen, M, Arcari, L, Engel, J, Freiwald, T, Platschek, S, Zhou, H, Zainal, H, Buettner, S, Zeiher, AM, Geiger, H, Hauser, I, Nagel, E & Puntmann, VO 2019, 'Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease', IJC HEART VASC, Jg. 24, 100389. https://doi.org/10.1016/j.ijcha.2019.100389

APA

Chen, M., Arcari, L., Engel, J., Freiwald, T., Platschek, S., Zhou, H., Zainal, H., Buettner, S., Zeiher, AM., Geiger, H., Hauser, I., Nagel, E., & Puntmann, VO. (2019). Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease. IJC HEART VASC, 24, [100389]. https://doi.org/10.1016/j.ijcha.2019.100389

Vancouver

Chen M, Arcari L, Engel J, Freiwald T, Platschek S, Zhou H et al. Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease. IJC HEART VASC. 2019 Jun;24. 100389. https://doi.org/10.1016/j.ijcha.2019.100389

Bibtex

@article{3510c265b231415fa4eadf81902ee2ae,
title = "Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease",
abstract = "BackgroundPatients with chronic kidney disease (CKD) have considerable cardiovascular morbidity and mortality. Aortic stiffness is an independent predictor of cardiovascular risk and related to left ventricular remodeling and heart failure. Myocardial fibrosis is the pathophysiological hallmark of the failing heart.Methods and resultsAn observational study of consecutive CKD patients (n = 276) undergoing comprehensive clinical cardiovascular magnetic resonance imaging. The relationship between aortic stiffness, myocardial fibrosis, left ventricular remodeling and the severity of chronic kidney disease was examined. Compared to age-gender matched controls with no known kidney disease (n = 242), CKD patients had considerably higher myocardial native T1 and central aortic PWV (p ≪ 0.001), as well as abnormal diastolic relaxation by E/e′ (mean) by echocardiography (p ≪ 0.01). A third of all patients had LGE, with similar proportions for the presence and the (ischaemic and non-ischaemic) pattern between the groups. PWV was strongly associated with and age, NT-proBNP and native T1 in both groups, but not with LGE presence or type; the associations were amplified in severe CKD stages. In multivariate analyses, PWV was independently associated with native T1 in both groups (p ≪ 0.01) with near two-fold increase in adjusted R2 in the presence of CKD (native T1 (10 ms) R2, B(95%CI) CKD vs. non-CKD 0.28, 0.2(0.15–0.25) vs. 0.18, 0.1(0.06–0.15), p ≪ 0.01).ConclusionsAortic stiffness and interstitial myocardial fibrosis are interrelated; this association is accelerated in the presence of CKD, but independent of LGE. Our findings reiterate the significant contribution of CKD-related factors to the pathophysiology of cardiovascular remodeling.",
author = "M Chen and L Arcari and J Engel and T Freiwald and S Platschek and H Zhou and H Zainal and S Buettner and AM Zeiher and H Geiger and I Hauser and E Nagel and VO Puntmann",
year = "2019",
month = jun,
doi = "10.1016/j.ijcha.2019.100389",
language = "English",
volume = "24",
journal = "IJC HEART VASC",
issn = "2352-9067",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease

AU - Chen, M

AU - Arcari, L

AU - Engel, J

AU - Freiwald, T

AU - Platschek, S

AU - Zhou, H

AU - Zainal, H

AU - Buettner, S

AU - Zeiher, AM

AU - Geiger, H

AU - Hauser, I

AU - Nagel, E

AU - Puntmann, VO

PY - 2019/6

Y1 - 2019/6

N2 - BackgroundPatients with chronic kidney disease (CKD) have considerable cardiovascular morbidity and mortality. Aortic stiffness is an independent predictor of cardiovascular risk and related to left ventricular remodeling and heart failure. Myocardial fibrosis is the pathophysiological hallmark of the failing heart.Methods and resultsAn observational study of consecutive CKD patients (n = 276) undergoing comprehensive clinical cardiovascular magnetic resonance imaging. The relationship between aortic stiffness, myocardial fibrosis, left ventricular remodeling and the severity of chronic kidney disease was examined. Compared to age-gender matched controls with no known kidney disease (n = 242), CKD patients had considerably higher myocardial native T1 and central aortic PWV (p ≪ 0.001), as well as abnormal diastolic relaxation by E/e′ (mean) by echocardiography (p ≪ 0.01). A third of all patients had LGE, with similar proportions for the presence and the (ischaemic and non-ischaemic) pattern between the groups. PWV was strongly associated with and age, NT-proBNP and native T1 in both groups, but not with LGE presence or type; the associations were amplified in severe CKD stages. In multivariate analyses, PWV was independently associated with native T1 in both groups (p ≪ 0.01) with near two-fold increase in adjusted R2 in the presence of CKD (native T1 (10 ms) R2, B(95%CI) CKD vs. non-CKD 0.28, 0.2(0.15–0.25) vs. 0.18, 0.1(0.06–0.15), p ≪ 0.01).ConclusionsAortic stiffness and interstitial myocardial fibrosis are interrelated; this association is accelerated in the presence of CKD, but independent of LGE. Our findings reiterate the significant contribution of CKD-related factors to the pathophysiology of cardiovascular remodeling.

AB - BackgroundPatients with chronic kidney disease (CKD) have considerable cardiovascular morbidity and mortality. Aortic stiffness is an independent predictor of cardiovascular risk and related to left ventricular remodeling and heart failure. Myocardial fibrosis is the pathophysiological hallmark of the failing heart.Methods and resultsAn observational study of consecutive CKD patients (n = 276) undergoing comprehensive clinical cardiovascular magnetic resonance imaging. The relationship between aortic stiffness, myocardial fibrosis, left ventricular remodeling and the severity of chronic kidney disease was examined. Compared to age-gender matched controls with no known kidney disease (n = 242), CKD patients had considerably higher myocardial native T1 and central aortic PWV (p ≪ 0.001), as well as abnormal diastolic relaxation by E/e′ (mean) by echocardiography (p ≪ 0.01). A third of all patients had LGE, with similar proportions for the presence and the (ischaemic and non-ischaemic) pattern between the groups. PWV was strongly associated with and age, NT-proBNP and native T1 in both groups, but not with LGE presence or type; the associations were amplified in severe CKD stages. In multivariate analyses, PWV was independently associated with native T1 in both groups (p ≪ 0.01) with near two-fold increase in adjusted R2 in the presence of CKD (native T1 (10 ms) R2, B(95%CI) CKD vs. non-CKD 0.28, 0.2(0.15–0.25) vs. 0.18, 0.1(0.06–0.15), p ≪ 0.01).ConclusionsAortic stiffness and interstitial myocardial fibrosis are interrelated; this association is accelerated in the presence of CKD, but independent of LGE. Our findings reiterate the significant contribution of CKD-related factors to the pathophysiology of cardiovascular remodeling.

UR - http://europepmc.org/abstract/med/31304234

U2 - 10.1016/j.ijcha.2019.100389

DO - 10.1016/j.ijcha.2019.100389

M3 - SCORING: Journal article

C2 - 31304234

VL - 24

JO - IJC HEART VASC

JF - IJC HEART VASC

SN - 2352-9067

M1 - 100389

ER -