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Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology.

Standard

Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology. / Solbach, Christine; Sterner-Kock, Anja; Roller, Marc; Schnürch, Hans Georg; Stegmüller, Manfred; Caspar-Bell, Gudrun; Schumm-Draeger, Petra Maria; Kaufmann, Manfred; Knecht, Rainald.

in: NEOPLASIA, Jahrgang 4, Nr. 3, 3, 2002, S. 237-242.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Solbach, C, Sterner-Kock, A, Roller, M, Schnürch, HG, Stegmüller, M, Caspar-Bell, G, Schumm-Draeger, PM, Kaufmann, M & Knecht, R 2002, 'Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology.', NEOPLASIA, Jg. 4, Nr. 3, 3, S. 237-242. https://doi.org/10.1038/sj.neo.7900236

APA

Solbach, C., Sterner-Kock, A., Roller, M., Schnürch, H. G., Stegmüller, M., Caspar-Bell, G., Schumm-Draeger, P. M., Kaufmann, M., & Knecht, R. (2002). Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology. NEOPLASIA, 4(3), 237-242. [3]. https://doi.org/10.1038/sj.neo.7900236

Vancouver

Solbach C, Sterner-Kock A, Roller M, Schnürch HG, Stegmüller M, Caspar-Bell G et al. Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology. NEOPLASIA. 2002;4(3):237-242. 3. https://doi.org/10.1038/sj.neo.7900236

Bibtex

@article{9edaea31b2b640ee9ab244209ed89c7b,
title = "Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology.",
abstract = "The proliferative stimulus of the epidermal growth factor (EGF) in human epithelial cells is mediated by its binding to the external domain of the EGF receptor (EGF-R). The purpose of this study was to investigate whether growth arrest of tumors treated with anti-EGF-R MAb (EMD 55900) was dependent on EGF-R expression and distinct histopathologic criteria of those neoplasms. Nine different adenocarcinomas, squamous cell carcinomas and two neoplastic epithelial cell lines (A431 and Detroit 562), which were characterized by high EGF-R expression, were xenotransplanted onto NMRI-nu/nu mice and treated with an anti-EGF-R antibody (EMD 55900). Results revealed that EGF-R expression and distinct histopathologic growth patterns play an important role for the therapeutic effect of the EGF-R antibody treatment. Tumors with high epithelial cellularity and little connective tissue responded to EMD 55900 treatment to a greater degree of growth reduction than tumors with lower cellularity. These results will be helpful for evaluation of patients who would benefit from tumor therapy with anti-EGF-R antibody.",
author = "Christine Solbach and Anja Sterner-Kock and Marc Roller and Schn{\"u}rch, {Hans Georg} and Manfred Stegm{\"u}ller and Gudrun Caspar-Bell and Schumm-Draeger, {Petra Maria} and Manfred Kaufmann and Rainald Knecht",
year = "2002",
doi = "10.1038/sj.neo.7900236",
language = "Deutsch",
volume = "4",
pages = "237--242",
journal = "NEOPLASIA",
issn = "1476-5586",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology.

AU - Solbach, Christine

AU - Sterner-Kock, Anja

AU - Roller, Marc

AU - Schnürch, Hans Georg

AU - Stegmüller, Manfred

AU - Caspar-Bell, Gudrun

AU - Schumm-Draeger, Petra Maria

AU - Kaufmann, Manfred

AU - Knecht, Rainald

PY - 2002

Y1 - 2002

N2 - The proliferative stimulus of the epidermal growth factor (EGF) in human epithelial cells is mediated by its binding to the external domain of the EGF receptor (EGF-R). The purpose of this study was to investigate whether growth arrest of tumors treated with anti-EGF-R MAb (EMD 55900) was dependent on EGF-R expression and distinct histopathologic criteria of those neoplasms. Nine different adenocarcinomas, squamous cell carcinomas and two neoplastic epithelial cell lines (A431 and Detroit 562), which were characterized by high EGF-R expression, were xenotransplanted onto NMRI-nu/nu mice and treated with an anti-EGF-R antibody (EMD 55900). Results revealed that EGF-R expression and distinct histopathologic growth patterns play an important role for the therapeutic effect of the EGF-R antibody treatment. Tumors with high epithelial cellularity and little connective tissue responded to EMD 55900 treatment to a greater degree of growth reduction than tumors with lower cellularity. These results will be helpful for evaluation of patients who would benefit from tumor therapy with anti-EGF-R antibody.

AB - The proliferative stimulus of the epidermal growth factor (EGF) in human epithelial cells is mediated by its binding to the external domain of the EGF receptor (EGF-R). The purpose of this study was to investigate whether growth arrest of tumors treated with anti-EGF-R MAb (EMD 55900) was dependent on EGF-R expression and distinct histopathologic criteria of those neoplasms. Nine different adenocarcinomas, squamous cell carcinomas and two neoplastic epithelial cell lines (A431 and Detroit 562), which were characterized by high EGF-R expression, were xenotransplanted onto NMRI-nu/nu mice and treated with an anti-EGF-R antibody (EMD 55900). Results revealed that EGF-R expression and distinct histopathologic growth patterns play an important role for the therapeutic effect of the EGF-R antibody treatment. Tumors with high epithelial cellularity and little connective tissue responded to EMD 55900 treatment to a greater degree of growth reduction than tumors with lower cellularity. These results will be helpful for evaluation of patients who would benefit from tumor therapy with anti-EGF-R antibody.

U2 - 10.1038/sj.neo.7900236

DO - 10.1038/sj.neo.7900236

M3 - SCORING: Zeitschriftenaufsatz

VL - 4

SP - 237

EP - 242

JO - NEOPLASIA

JF - NEOPLASIA

SN - 1476-5586

IS - 3

M1 - 3

ER -