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Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells

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Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells. / Fang, Lubin; Fehse, Boris; Engel, Melanie; Zander, Axel; Kröger, Nicolaus.

in: TRANSPLANTATION, Jahrgang 79, Nr. 3, 15.02.2005, S. 369-371.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Kurzpublikation › Forschung › Begutachtung

Harvard

Fang, L, Fehse, B, Engel, M, Zander, A & Kröger, N 2005, 'Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells', TRANSPLANTATION, Jg. 79, Nr. 3, S. 369-371. https://doi.org/10.1097/01.tp.0000150210.77543.1b

APA

Fang, L., Fehse, B., Engel, M., Zander, A., & Kröger, N. (2005). Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells. TRANSPLANTATION, 79(3), 369-371. https://doi.org/10.1097/01.tp.0000150210.77543.1b

Vancouver

Fang L, Fehse B, Engel M, Zander A, Kröger N. Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells. TRANSPLANTATION. 2005 Feb 15;79(3):369-371. https://doi.org/10.1097/01.tp.0000150210.77543.1b

Bibtex

@article{22ea168bb86942e7ba1b8e20a39a4c72,
title = "Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells",
abstract = "We investigate the in vivo and ex vivo effect of rabbit antithymocyte globulin (ATG) on myeloid dendritic cells (MDCs) and plasmacytoid dendritic cells (PDCs). After incubation with ATG and complement, the mean number of MDCs and PDCs decreases from 3,168 to 739 x 10/mL (P=0.004) and from 5,314 to 790 x 10/mL (P=0.01), respectively. In vivo ATG given as part of the conditioning regimen before allogeneic stem-cell transplantation induces a stronger reduction of circulating MDCs and PDCs than chemotherapy alone (reduction: 100% vs. 78%-98%). These data show that ATG induces depletion of circulating MDCs and PDCs, which might be in addition to the T-cell depletion a further mechanism to reduce graft-versus-host disease after allogeneic stem-cell transplantation.",
keywords = "Adult, Antilymphocyte Serum/pharmacology, Dendritic Cells/cytology, Female, Humans, Leukemia/therapy, Lymphocyte Depletion, Male, Middle Aged, Multiple Myeloma/therapy, Reference Values, Stem Cell Transplantation",
author = "Lubin Fang and Boris Fehse and Melanie Engel and Axel Zander and Nicolaus Kr{\"o}ger",
year = "2005",
month = feb,
day = "15",
doi = "10.1097/01.tp.0000150210.77543.1b",
language = "English",
volume = "79",
pages = "369--371",
journal = "TRANSPLANTATION",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells

AU - Fang, Lubin

AU - Fehse, Boris

AU - Engel, Melanie

AU - Zander, Axel

AU - Kröger, Nicolaus

PY - 2005/2/15

Y1 - 2005/2/15

N2 - We investigate the in vivo and ex vivo effect of rabbit antithymocyte globulin (ATG) on myeloid dendritic cells (MDCs) and plasmacytoid dendritic cells (PDCs). After incubation with ATG and complement, the mean number of MDCs and PDCs decreases from 3,168 to 739 x 10/mL (P=0.004) and from 5,314 to 790 x 10/mL (P=0.01), respectively. In vivo ATG given as part of the conditioning regimen before allogeneic stem-cell transplantation induces a stronger reduction of circulating MDCs and PDCs than chemotherapy alone (reduction: 100% vs. 78%-98%). These data show that ATG induces depletion of circulating MDCs and PDCs, which might be in addition to the T-cell depletion a further mechanism to reduce graft-versus-host disease after allogeneic stem-cell transplantation.

AB - We investigate the in vivo and ex vivo effect of rabbit antithymocyte globulin (ATG) on myeloid dendritic cells (MDCs) and plasmacytoid dendritic cells (PDCs). After incubation with ATG and complement, the mean number of MDCs and PDCs decreases from 3,168 to 739 x 10/mL (P=0.004) and from 5,314 to 790 x 10/mL (P=0.01), respectively. In vivo ATG given as part of the conditioning regimen before allogeneic stem-cell transplantation induces a stronger reduction of circulating MDCs and PDCs than chemotherapy alone (reduction: 100% vs. 78%-98%). These data show that ATG induces depletion of circulating MDCs and PDCs, which might be in addition to the T-cell depletion a further mechanism to reduce graft-versus-host disease after allogeneic stem-cell transplantation.

KW - Adult

KW - Antilymphocyte Serum/pharmacology

KW - Dendritic Cells/cytology

KW - Female

KW - Humans

KW - Leukemia/therapy

KW - Lymphocyte Depletion

KW - Male

KW - Middle Aged

KW - Multiple Myeloma/therapy

KW - Reference Values

KW - Stem Cell Transplantation

U2 - 10.1097/01.tp.0000150210.77543.1b

DO - 10.1097/01.tp.0000150210.77543.1b

M3 - Short publication

C2 - 15699773

VL - 79

SP - 369

EP - 371

JO - TRANSPLANTATION

JF - TRANSPLANTATION

SN - 0041-1337

IS - 3

ER -