Anti-SARS-CoV-2 antibodies in breast milk during lactation after infection or vaccination: A cohort study
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Anti-SARS-CoV-2 antibodies in breast milk during lactation after infection or vaccination: A cohort study. / Olearo, Flaminia; Radmanesh, Laura-Sophie; Felber, Nadine; von Possel, Ronald; Emmerich, Petra; Pekarek, Neele; Pfefferle, Susanne; Nörz, Dominik; Hansen, Gudula; Diemert, Anke; Aepfelbacher, Martin; Hecher, Kurt; Lütgehetmann, Marc; Arck, Petra Clara; Tallarek, Ann-Christin.
in: J REPROD IMMUNOL, Jahrgang 153, 103685, 09.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Anti-SARS-CoV-2 antibodies in breast milk during lactation after infection or vaccination: A cohort study
AU - Olearo, Flaminia
AU - Radmanesh, Laura-Sophie
AU - Felber, Nadine
AU - von Possel, Ronald
AU - Emmerich, Petra
AU - Pekarek, Neele
AU - Pfefferle, Susanne
AU - Nörz, Dominik
AU - Hansen, Gudula
AU - Diemert, Anke
AU - Aepfelbacher, Martin
AU - Hecher, Kurt
AU - Lütgehetmann, Marc
AU - Arck, Petra Clara
AU - Tallarek, Ann-Christin
N1 - Copyright © 2022 Elsevier B.V. All rights reserved.
PY - 2022/9
Y1 - 2022/9
N2 - Breast milk is a pivotal source to provide passive immunity in newborns over the first few months of life. Very little is known about the antibody transfer levels over the period of breastfeeding. We conducted a prospective study in which we evaluated concentrations of anti-SARS-CoV-2 Spike IgA and RBD IgG/M/A antibodies in maternal serum and breast milk over a duration of up to 6 months after delivery. We compared antibody levels in women with confirmed COVID-19 infection during pregnancy (n = 16) to women with prenatal SARS-CoV-2 vaccination (n = 5). Among the recovered women, n = 7 (44%) had been vaccinated during the lactation period as well. We observed intraindividual moderate positive correlations between antibody levels in maternal serum and breast milk (r = 0.73, p-value<0.0001), whereupon the median levels were generally higher in serum. Anti-RBD IgA/M/G transfer into breast milk was significantly higher in women recovered from COVID-19 and vaccinated during lactation (35.15 AU/ml; IQR 21.96-66.89 AU/ml) compared to the nonvaccinated recovered group (1.26 AU/ml; IQR 0.49-3.81 AU/ml), as well as in the vaccinated only group (4.52 AU/ml; IQR 3.19-6.23 AU/ml). Notably, the antibody level in breast milk post SARS-CoV-2 infection sharply increased following a single dose of vaccine. Breast milk antibodies in all groups showed neutralization capacities against an early pandemic SARS-CoV-2 isolate (HH-1) and moreover, also against the Omicron variant, although with lower antibody titer. Our findings highlight the importance of booster vaccinations especially after SARS-CoV-2 infection in pregnancy in order to optimize protection in mother and newborn.
AB - Breast milk is a pivotal source to provide passive immunity in newborns over the first few months of life. Very little is known about the antibody transfer levels over the period of breastfeeding. We conducted a prospective study in which we evaluated concentrations of anti-SARS-CoV-2 Spike IgA and RBD IgG/M/A antibodies in maternal serum and breast milk over a duration of up to 6 months after delivery. We compared antibody levels in women with confirmed COVID-19 infection during pregnancy (n = 16) to women with prenatal SARS-CoV-2 vaccination (n = 5). Among the recovered women, n = 7 (44%) had been vaccinated during the lactation period as well. We observed intraindividual moderate positive correlations between antibody levels in maternal serum and breast milk (r = 0.73, p-value<0.0001), whereupon the median levels were generally higher in serum. Anti-RBD IgA/M/G transfer into breast milk was significantly higher in women recovered from COVID-19 and vaccinated during lactation (35.15 AU/ml; IQR 21.96-66.89 AU/ml) compared to the nonvaccinated recovered group (1.26 AU/ml; IQR 0.49-3.81 AU/ml), as well as in the vaccinated only group (4.52 AU/ml; IQR 3.19-6.23 AU/ml). Notably, the antibody level in breast milk post SARS-CoV-2 infection sharply increased following a single dose of vaccine. Breast milk antibodies in all groups showed neutralization capacities against an early pandemic SARS-CoV-2 isolate (HH-1) and moreover, also against the Omicron variant, although with lower antibody titer. Our findings highlight the importance of booster vaccinations especially after SARS-CoV-2 infection in pregnancy in order to optimize protection in mother and newborn.
KW - Antibodies, Viral
KW - Breast Feeding
KW - COVID-19/prevention & control
KW - COVID-19 Vaccines
KW - Cohort Studies
KW - Female
KW - Humans
KW - Immunoglobulin A
KW - Immunoglobulin G
KW - Infant, Newborn
KW - Lactation
KW - Milk, Human
KW - Prospective Studies
KW - SARS-CoV-2
KW - Vaccination
KW - Viral Vaccines
U2 - 10.1016/j.jri.2022.103685
DO - 10.1016/j.jri.2022.103685
M3 - SCORING: Journal article
C2 - 36029724
VL - 153
JO - J REPROD IMMUNOL
JF - J REPROD IMMUNOL
SN - 0165-0378
M1 - 103685
ER -
