Antipsychotics decrease response confidence
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Antipsychotics decrease response confidence. / Moritz, Steffen; Kolbeck, Katharina; Andreou, Christina.
in: J PSYCHOPHARMACOL, Jahrgang 30, Nr. 8, 08.2016, S. 831-3.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Antipsychotics decrease response confidence
AU - Moritz, Steffen
AU - Kolbeck, Katharina
AU - Andreou, Christina
N1 - © The Author(s) 2016.
PY - 2016/8
Y1 - 2016/8
N2 - Antipsychotics represent the first-choice treatment for schizophrenia. However, the cognitive and emotional pathways through which symptom reduction is achieved have remained unclear. We recently proposed that the induction of doubt is a core mechanism of action of antipsychotics. In the framework of a randomized, double-blind, placebo-controlled, crossover design, 39 nonclinical participants filled out a questionnaire tapping into cognitive and emotional changes (Effect of Antipsychotic Medication on Emotion and Cognition-revised (EAMEC-r)) each time they had received one of three substances (haloperidol, placebo, L-dopa). Participants reported more doubt under haloperidol than under L-dopa lending support to the theory that antipsychotics decrease delusional conviction via the reduction of confidence. Key points from this study are: (a) antipsychotics induce doubt, and (b) doubt may represent a core mechanism of action for the reduction of delusional ideas.
AB - Antipsychotics represent the first-choice treatment for schizophrenia. However, the cognitive and emotional pathways through which symptom reduction is achieved have remained unclear. We recently proposed that the induction of doubt is a core mechanism of action of antipsychotics. In the framework of a randomized, double-blind, placebo-controlled, crossover design, 39 nonclinical participants filled out a questionnaire tapping into cognitive and emotional changes (Effect of Antipsychotic Medication on Emotion and Cognition-revised (EAMEC-r)) each time they had received one of three substances (haloperidol, placebo, L-dopa). Participants reported more doubt under haloperidol than under L-dopa lending support to the theory that antipsychotics decrease delusional conviction via the reduction of confidence. Key points from this study are: (a) antipsychotics induce doubt, and (b) doubt may represent a core mechanism of action for the reduction of delusional ideas.
U2 - 10.1177/0269881116650404
DO - 10.1177/0269881116650404
M3 - SCORING: Journal article
C2 - 27222269
VL - 30
SP - 831
EP - 833
JO - J PSYCHOPHARMACOL
JF - J PSYCHOPHARMACOL
SN - 0269-8811
IS - 8
ER -
