Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells.
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Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells. / von Bueren, André; André, O; Shalaby, Tarek; Rajtarova, Julia; Stearns, Duncan; Eberhart, Charles G; Helson, Lawrence; Arcaro, Alexandre; Grotzer, Michael A.
in: BMC CANCER, Jahrgang 7, 2007, S. 19.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells.
AU - von Bueren, André
AU - André, O
AU - Shalaby, Tarek
AU - Rajtarova, Julia
AU - Stearns, Duncan
AU - Eberhart, Charles G
AU - Helson, Lawrence
AU - Arcaro, Alexandre
AU - Grotzer, Michael A
PY - 2007
Y1 - 2007
N2 - With current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulation of c-MYC is evident in numerous human cancers. In MB, over-expression of c-MYC has been shown to correlate with anaplasia and unfavorable prognosis. In neuroblastoma--an embryonal tumor with biological similarities to MB--the quassinoid NBT-272 has been demonstrated to inhibit cellular proliferation and to down-regulate c-MYC protein expression.
AB - With current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulation of c-MYC is evident in numerous human cancers. In MB, over-expression of c-MYC has been shown to correlate with anaplasia and unfavorable prognosis. In neuroblastoma--an embryonal tumor with biological similarities to MB--the quassinoid NBT-272 has been demonstrated to inhibit cellular proliferation and to down-regulate c-MYC protein expression.
M3 - SCORING: Zeitschriftenaufsatz
VL - 7
SP - 19
JO - BMC CANCER
JF - BMC CANCER
SN - 1471-2407
ER -