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Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination

Standard

Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination. / Dannhäuser, Sven; Lux, Thomas J; Hu, Chun; Selcho, Mareike; Chen, Jeremy T-C; Ehmann, Nadine; Sachidanandan, Divya; Stopp, Sarah; Pauls, Dennis; Pawlak, Matthias; Langenhan, Tobias; Soba, Peter; Rittner, Heike L; Kittel, Robert J.

in: ELIFE, Jahrgang 9, 30.09.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dannhäuser, S, Lux, TJ, Hu, C, Selcho, M, Chen, JT-C, Ehmann, N, Sachidanandan, D, Stopp, S, Pauls, D, Pawlak, M, Langenhan, T, Soba, P, Rittner, HL & Kittel, RJ 2020, 'Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination', ELIFE, Jg. 9. https://doi.org/10.7554/eLife.56738

APA

Dannhäuser, S., Lux, T. J., Hu, C., Selcho, M., Chen, J. T-C., Ehmann, N., Sachidanandan, D., Stopp, S., Pauls, D., Pawlak, M., Langenhan, T., Soba, P., Rittner, H. L., & Kittel, R. J. (2020). Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination. ELIFE, 9. https://doi.org/10.7554/eLife.56738

Vancouver

Dannhäuser S, Lux TJ, Hu C, Selcho M, Chen JT-C, Ehmann N et al. Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination. ELIFE. 2020 Sep 30;9. https://doi.org/10.7554/eLife.56738

Bibtex

@article{0fffd0c2a1354cf8a24308a39d2ed663,
title = "Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination",
abstract = "Adhesion-type GPCRs (aGPCRs) participate in a vast range of physiological processes. Their frequent association with mechanosensitive functions suggests that processing of mechanical stimuli may be a common feature of this receptor family. Previously, we reported that the Drosophila aGPCR CIRL sensitizes sensory responses to gentle touch and sound by amplifying signal transduction in low-threshold mechanoreceptors (Scholz et al., 2017). Here, we show that Cirl is also expressed in high-threshold mechanical nociceptors where it adjusts nocifensive behaviour under physiological and pathological conditions. Optogenetic in vivo experiments indicate that CIRL lowers cAMP levels in both mechanosensory submodalities. However, contrasting its role in touch-sensitive neurons, CIRL dampens the response of nociceptors to mechanical stimulation. Consistent with this finding, rat nociceptors display decreased Cirl1 expression during allodynia. Thus, cAMP-downregulation by CIRL exerts opposing effects on low-threshold mechanosensors and high-threshold nociceptors. This intriguing bipolar action facilitates the separation of mechanosensory signals carrying different physiological information.",
author = "Sven Dannh{\"a}user and Lux, {Thomas J} and Chun Hu and Mareike Selcho and Chen, {Jeremy T-C} and Nadine Ehmann and Divya Sachidanandan and Sarah Stopp and Dennis Pauls and Matthias Pawlak and Tobias Langenhan and Peter Soba and Rittner, {Heike L} and Kittel, {Robert J}",
note = "{\textcopyright} 2020, Dannh{\"a}user et al.",
year = "2020",
month = sep,
day = "30",
doi = "10.7554/eLife.56738",
language = "English",
volume = "9",
journal = "ELIFE",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination

AU - Dannhäuser, Sven

AU - Lux, Thomas J

AU - Hu, Chun

AU - Selcho, Mareike

AU - Chen, Jeremy T-C

AU - Ehmann, Nadine

AU - Sachidanandan, Divya

AU - Stopp, Sarah

AU - Pauls, Dennis

AU - Pawlak, Matthias

AU - Langenhan, Tobias

AU - Soba, Peter

AU - Rittner, Heike L

AU - Kittel, Robert J

N1 - © 2020, Dannhäuser et al.

PY - 2020/9/30

Y1 - 2020/9/30

N2 - Adhesion-type GPCRs (aGPCRs) participate in a vast range of physiological processes. Their frequent association with mechanosensitive functions suggests that processing of mechanical stimuli may be a common feature of this receptor family. Previously, we reported that the Drosophila aGPCR CIRL sensitizes sensory responses to gentle touch and sound by amplifying signal transduction in low-threshold mechanoreceptors (Scholz et al., 2017). Here, we show that Cirl is also expressed in high-threshold mechanical nociceptors where it adjusts nocifensive behaviour under physiological and pathological conditions. Optogenetic in vivo experiments indicate that CIRL lowers cAMP levels in both mechanosensory submodalities. However, contrasting its role in touch-sensitive neurons, CIRL dampens the response of nociceptors to mechanical stimulation. Consistent with this finding, rat nociceptors display decreased Cirl1 expression during allodynia. Thus, cAMP-downregulation by CIRL exerts opposing effects on low-threshold mechanosensors and high-threshold nociceptors. This intriguing bipolar action facilitates the separation of mechanosensory signals carrying different physiological information.

AB - Adhesion-type GPCRs (aGPCRs) participate in a vast range of physiological processes. Their frequent association with mechanosensitive functions suggests that processing of mechanical stimuli may be a common feature of this receptor family. Previously, we reported that the Drosophila aGPCR CIRL sensitizes sensory responses to gentle touch and sound by amplifying signal transduction in low-threshold mechanoreceptors (Scholz et al., 2017). Here, we show that Cirl is also expressed in high-threshold mechanical nociceptors where it adjusts nocifensive behaviour under physiological and pathological conditions. Optogenetic in vivo experiments indicate that CIRL lowers cAMP levels in both mechanosensory submodalities. However, contrasting its role in touch-sensitive neurons, CIRL dampens the response of nociceptors to mechanical stimulation. Consistent with this finding, rat nociceptors display decreased Cirl1 expression during allodynia. Thus, cAMP-downregulation by CIRL exerts opposing effects on low-threshold mechanosensors and high-threshold nociceptors. This intriguing bipolar action facilitates the separation of mechanosensory signals carrying different physiological information.

U2 - 10.7554/eLife.56738

DO - 10.7554/eLife.56738

M3 - SCORING: Journal article

C2 - 32996461

VL - 9

JO - ELIFE

JF - ELIFE

SN - 2050-084X

ER -