Antiinflammatorische Wirksamkeit von 7 Pflanzenextrakten im Ultraviolett-Erythemtest. Eine randomisierte, placebokontrollierte Studie
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Antiinflammatorische Wirksamkeit von 7 Pflanzenextrakten im Ultraviolett-Erythemtest. Eine randomisierte, placebokontrollierte Studie. / Beikert, F C; Schönfeld, B S; Frank, U; Augustin, M.
in: HAUTARZT, Jahrgang 64, Nr. 1, 01.01.2013, S. 40-6.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Antiinflammatorische Wirksamkeit von 7 Pflanzenextrakten im Ultraviolett-Erythemtest. Eine randomisierte, placebokontrollierte Studie
AU - Beikert, F C
AU - Schönfeld, B S
AU - Frank, U
AU - Augustin, M
PY - 2013/1/1
Y1 - 2013/1/1
N2 - BACKGROUND: Phytotherapeutics are widely used in medicine. The aim of this study was the evaluation of the antiinflammatory potential of seven medical plant extracts using the ultraviolet- (UV)-erythema test.PATIENTS AND METHODS: Randomized, placebo-controlled study on 40 healthy subjects. Test areas on the upper back were irradiated with the 1.5 fold UV-B minimal erythema dose (MED). Formulations of Aloe vera, Chamomilla recutita, Hamamelis virginiana, Melissa officinalis, Mentha arvensis, Melaleuca alternifolia, Coriandrum sativum as well as 1% hydrocortisone acetate and 0.1% betamethasone valerate as positive controls and unguentum leniens as vehicle control were applied under occlusion on the irradiated areas and on non-irradiated area on the contralateral side. Photometric assessment of the erythema was performed before the application of the substances (t0), at 24 h (t1) and at 48 h (t2).RESULTS: Aloe vera, Chamomilla recutita, Melissa officinalis, Melaleuca alternifolia and Coriandrum sativum showed an antiinflammatory effect compared to UV-control and unguentum leniens. However, the results were only statistically significant for Aloe vera. All tested plant extracts were well tolerated.CONCLUSION: Aloe vera possesses an antiinflammatory effect on UV-induced erythemas.
AB - BACKGROUND: Phytotherapeutics are widely used in medicine. The aim of this study was the evaluation of the antiinflammatory potential of seven medical plant extracts using the ultraviolet- (UV)-erythema test.PATIENTS AND METHODS: Randomized, placebo-controlled study on 40 healthy subjects. Test areas on the upper back were irradiated with the 1.5 fold UV-B minimal erythema dose (MED). Formulations of Aloe vera, Chamomilla recutita, Hamamelis virginiana, Melissa officinalis, Mentha arvensis, Melaleuca alternifolia, Coriandrum sativum as well as 1% hydrocortisone acetate and 0.1% betamethasone valerate as positive controls and unguentum leniens as vehicle control were applied under occlusion on the irradiated areas and on non-irradiated area on the contralateral side. Photometric assessment of the erythema was performed before the application of the substances (t0), at 24 h (t1) and at 48 h (t2).RESULTS: Aloe vera, Chamomilla recutita, Melissa officinalis, Melaleuca alternifolia and Coriandrum sativum showed an antiinflammatory effect compared to UV-control and unguentum leniens. However, the results were only statistically significant for Aloe vera. All tested plant extracts were well tolerated.CONCLUSION: Aloe vera possesses an antiinflammatory effect on UV-induced erythemas.
KW - Adult
KW - Anti-Inflammatory Agents
KW - Erythema
KW - Feasibility Studies
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Phytotherapy
KW - Placebo Effect
KW - Plant Extracts
KW - Treatment Outcome
KW - Ultraviolet Rays
KW - Young Adult
U2 - 10.1007/s00105-012-2505-x
DO - 10.1007/s00105-012-2505-x
M3 - SCORING: Zeitschriftenaufsatz
C2 - 23337964
VL - 64
SP - 40
EP - 46
JO - HAUTARZT
JF - HAUTARZT
SN - 0017-8470
IS - 1
ER -
