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Antigen-specific CD8+ T cell responses in intestinal tissues during murine listeriosis

Standard

Antigen-specific CD8+ T cell responses in intestinal tissues during murine listeriosis. / Kursar, Mischo; Bonhagen, Kerstin; Köhler, Anne; Kamradt, Thomas; Kaufmann, Stefan H E; Mittrücker, Hans Willi; Mittrücker, Hans-Willi.

in: MICROBES INFECT, Jahrgang 6, Nr. 1, 01.01.2004, S. 8-16.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kursar, M, Bonhagen, K, Köhler, A, Kamradt, T, Kaufmann, SHE, Mittrücker, HW & Mittrücker, H-W 2004, 'Antigen-specific CD8+ T cell responses in intestinal tissues during murine listeriosis', MICROBES INFECT, Jg. 6, Nr. 1, S. 8-16.

APA

Kursar, M., Bonhagen, K., Köhler, A., Kamradt, T., Kaufmann, S. H. E., Mittrücker, H. W., & Mittrücker, H-W. (2004). Antigen-specific CD8+ T cell responses in intestinal tissues during murine listeriosis. MICROBES INFECT, 6(1), 8-16.

Vancouver

Kursar M, Bonhagen K, Köhler A, Kamradt T, Kaufmann SHE, Mittrücker HW et al. Antigen-specific CD8+ T cell responses in intestinal tissues during murine listeriosis. MICROBES INFECT. 2004 Jan 1;6(1):8-16.

Bibtex

@article{a60ecb8a5d9648658a2950239989a280,
title = "Antigen-specific CD8+ T cell responses in intestinal tissues during murine listeriosis",
abstract = "Infection of mice with Listeria monocytogenes induces a strong CD8+ T cell response, which is critical for the control of bacteria and for protection against re-infection. We analyzed the CD8+ T cell response in different intestinal tissues following oral and intravenous (i.v.) L. monocytogenes infection. After oral infection, bacterial titers in small intestine and large intestine, and the listeria-specific CD8+ T cell response in the mucosa of both parts of the intestine, were highly correlated. Oral infection of CD28-deficient mice revealed that this response was strictly dependent on CD28 costimulation. Significant listeria-specific CD8+ T cell responses also occurred in all intestinal tissues analyzed after i.v. infection or after DNA vaccination, indicating that the accumulation of listeria-specific CD8+ T cells in these tissues only partially depends on local antigen presentation and inflammation.",
keywords = "Animals, Antigens, CD28, Bacterial Vaccines, CD8-Positive T-Lymphocytes, Disease Models, Animal, Intestinal Mucosa, Listeria monocytogenes, Listeriosis, Mice, Mice, Inbred BALB C, Mice, Knockout, Vaccination, Vaccines, DNA",
author = "Mischo Kursar and Kerstin Bonhagen and Anne K{\"o}hler and Thomas Kamradt and Kaufmann, {Stefan H E} and Mittr{\"u}cker, {Hans Willi} and Hans-Willi Mittr{\"u}cker",
year = "2004",
month = jan,
day = "1",
language = "English",
volume = "6",
pages = "8--16",
journal = "MICROBES INFECT",
issn = "1286-4579",
publisher = "Elsevier Masson SAS",
number = "1",

}

RIS

TY - JOUR

T1 - Antigen-specific CD8+ T cell responses in intestinal tissues during murine listeriosis

AU - Kursar, Mischo

AU - Bonhagen, Kerstin

AU - Köhler, Anne

AU - Kamradt, Thomas

AU - Kaufmann, Stefan H E

AU - Mittrücker, Hans Willi

AU - Mittrücker, Hans-Willi

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Infection of mice with Listeria monocytogenes induces a strong CD8+ T cell response, which is critical for the control of bacteria and for protection against re-infection. We analyzed the CD8+ T cell response in different intestinal tissues following oral and intravenous (i.v.) L. monocytogenes infection. After oral infection, bacterial titers in small intestine and large intestine, and the listeria-specific CD8+ T cell response in the mucosa of both parts of the intestine, were highly correlated. Oral infection of CD28-deficient mice revealed that this response was strictly dependent on CD28 costimulation. Significant listeria-specific CD8+ T cell responses also occurred in all intestinal tissues analyzed after i.v. infection or after DNA vaccination, indicating that the accumulation of listeria-specific CD8+ T cells in these tissues only partially depends on local antigen presentation and inflammation.

AB - Infection of mice with Listeria monocytogenes induces a strong CD8+ T cell response, which is critical for the control of bacteria and for protection against re-infection. We analyzed the CD8+ T cell response in different intestinal tissues following oral and intravenous (i.v.) L. monocytogenes infection. After oral infection, bacterial titers in small intestine and large intestine, and the listeria-specific CD8+ T cell response in the mucosa of both parts of the intestine, were highly correlated. Oral infection of CD28-deficient mice revealed that this response was strictly dependent on CD28 costimulation. Significant listeria-specific CD8+ T cell responses also occurred in all intestinal tissues analyzed after i.v. infection or after DNA vaccination, indicating that the accumulation of listeria-specific CD8+ T cells in these tissues only partially depends on local antigen presentation and inflammation.

KW - Animals

KW - Antigens, CD28

KW - Bacterial Vaccines

KW - CD8-Positive T-Lymphocytes

KW - Disease Models, Animal

KW - Intestinal Mucosa

KW - Listeria monocytogenes

KW - Listeriosis

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Knockout

KW - Vaccination

KW - Vaccines, DNA

M3 - SCORING: Journal article

C2 - 14738888

VL - 6

SP - 8

EP - 16

JO - MICROBES INFECT

JF - MICROBES INFECT

SN - 1286-4579

IS - 1

ER -