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Anticipatory postural adjustments are modulated by substantia nigra stimulation in people with Parkinson's disease and freezing of gait

Standard

Anticipatory postural adjustments are modulated by substantia nigra stimulation in people with Parkinson's disease and freezing of gait. / Heilbronn, Melanie; Scholten, Marlieke; Schlenstedt, Christian; Mancini, Martina; Schöllmann, Anna; Cebi, Idil; Pötter-Nerger, Monika; Gharabaghi, Alireza; Weiss, Daniel.

in: PARKINSONISM RELAT D, Jahrgang 66, 09.2019, S. 34-39.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heilbronn, M, Scholten, M, Schlenstedt, C, Mancini, M, Schöllmann, A, Cebi, I, Pötter-Nerger, M, Gharabaghi, A & Weiss, D 2019, 'Anticipatory postural adjustments are modulated by substantia nigra stimulation in people with Parkinson's disease and freezing of gait', PARKINSONISM RELAT D, Jg. 66, S. 34-39. https://doi.org/10.1016/j.parkreldis.2019.06.023

APA

Heilbronn, M., Scholten, M., Schlenstedt, C., Mancini, M., Schöllmann, A., Cebi, I., Pötter-Nerger, M., Gharabaghi, A., & Weiss, D. (2019). Anticipatory postural adjustments are modulated by substantia nigra stimulation in people with Parkinson's disease and freezing of gait. PARKINSONISM RELAT D, 66, 34-39. https://doi.org/10.1016/j.parkreldis.2019.06.023

Vancouver

Heilbronn M, Scholten M, Schlenstedt C, Mancini M, Schöllmann A, Cebi I et al. Anticipatory postural adjustments are modulated by substantia nigra stimulation in people with Parkinson's disease and freezing of gait. PARKINSONISM RELAT D. 2019 Sep;66:34-39. https://doi.org/10.1016/j.parkreldis.2019.06.023

Bibtex

@article{a6d3e8cf0ab24e90aa2f58d3246a7cd2,
title = "Anticipatory postural adjustments are modulated by substantia nigra stimulation in people with Parkinson's disease and freezing of gait",
abstract = "BACKGROUND: A precise understanding of the neuronal circuits involved in the control of anticipatory postural adjustments (APAs) for gait initiation is missing. Neurostimulation in Parkinson's disease (PD) provides a method of modulating APAs to gain insight into the underlying circuitry.OBJECTIVE: Our objective was to investigate if APA kinematics for step initiation could be modulated by high frequency stimulation of the subthalamic nucleus (STN) or substantia nigra pars reticulata (SNr) in people with PD and freezing of gait (FoG).METHODS: We studied 14 people with PD and FoG using neurostimulation of the STN and SNr areas after overnight withdrawal of dopaminergic medication on the instrumented stand and walk test. We tested patients in the following randomized conditions: 'off stimulation', 'STN' stimulation (only), and 'SNr' stimulation (only). Patients were blinded to the stimulation condition. The APAs were recorded with inertial sensors and processed offline. Moreover, we assessed clinical scores with respect to motor symptoms, non-motor symptoms, executive function, and FoG.RESULTS: SNr but not STN stimulation modulated the anterio-posterior size of APA. The SNr modulation of APA was associated with the stimulation effect on FoG (trend; r = 0.580, P = 0.102). The APA modulation was not correlated with any other cognitive or clinical measures.CONCLUSION: Neuromodulation of the SNr but not of the STN modulated APAs in PD patients with FoG. The different effects of STN or SNr on the kinematic parameters of APA support the concept of segregate targets in order to address diverse kinematic components of PD gait.",
author = "Melanie Heilbronn and Marlieke Scholten and Christian Schlenstedt and Martina Mancini and Anna Sch{\"o}llmann and Idil Cebi and Monika P{\"o}tter-Nerger and Alireza Gharabaghi and Daniel Weiss",
note = "Copyright {\textcopyright} 2019 Elsevier Ltd. All rights reserved.",
year = "2019",
month = sep,
doi = "10.1016/j.parkreldis.2019.06.023",
language = "English",
volume = "66",
pages = "34--39",
journal = "PARKINSONISM RELAT D",
issn = "1353-8020",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Anticipatory postural adjustments are modulated by substantia nigra stimulation in people with Parkinson's disease and freezing of gait

AU - Heilbronn, Melanie

AU - Scholten, Marlieke

AU - Schlenstedt, Christian

AU - Mancini, Martina

AU - Schöllmann, Anna

AU - Cebi, Idil

AU - Pötter-Nerger, Monika

AU - Gharabaghi, Alireza

AU - Weiss, Daniel

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2019/9

Y1 - 2019/9

N2 - BACKGROUND: A precise understanding of the neuronal circuits involved in the control of anticipatory postural adjustments (APAs) for gait initiation is missing. Neurostimulation in Parkinson's disease (PD) provides a method of modulating APAs to gain insight into the underlying circuitry.OBJECTIVE: Our objective was to investigate if APA kinematics for step initiation could be modulated by high frequency stimulation of the subthalamic nucleus (STN) or substantia nigra pars reticulata (SNr) in people with PD and freezing of gait (FoG).METHODS: We studied 14 people with PD and FoG using neurostimulation of the STN and SNr areas after overnight withdrawal of dopaminergic medication on the instrumented stand and walk test. We tested patients in the following randomized conditions: 'off stimulation', 'STN' stimulation (only), and 'SNr' stimulation (only). Patients were blinded to the stimulation condition. The APAs were recorded with inertial sensors and processed offline. Moreover, we assessed clinical scores with respect to motor symptoms, non-motor symptoms, executive function, and FoG.RESULTS: SNr but not STN stimulation modulated the anterio-posterior size of APA. The SNr modulation of APA was associated with the stimulation effect on FoG (trend; r = 0.580, P = 0.102). The APA modulation was not correlated with any other cognitive or clinical measures.CONCLUSION: Neuromodulation of the SNr but not of the STN modulated APAs in PD patients with FoG. The different effects of STN or SNr on the kinematic parameters of APA support the concept of segregate targets in order to address diverse kinematic components of PD gait.

AB - BACKGROUND: A precise understanding of the neuronal circuits involved in the control of anticipatory postural adjustments (APAs) for gait initiation is missing. Neurostimulation in Parkinson's disease (PD) provides a method of modulating APAs to gain insight into the underlying circuitry.OBJECTIVE: Our objective was to investigate if APA kinematics for step initiation could be modulated by high frequency stimulation of the subthalamic nucleus (STN) or substantia nigra pars reticulata (SNr) in people with PD and freezing of gait (FoG).METHODS: We studied 14 people with PD and FoG using neurostimulation of the STN and SNr areas after overnight withdrawal of dopaminergic medication on the instrumented stand and walk test. We tested patients in the following randomized conditions: 'off stimulation', 'STN' stimulation (only), and 'SNr' stimulation (only). Patients were blinded to the stimulation condition. The APAs were recorded with inertial sensors and processed offline. Moreover, we assessed clinical scores with respect to motor symptoms, non-motor symptoms, executive function, and FoG.RESULTS: SNr but not STN stimulation modulated the anterio-posterior size of APA. The SNr modulation of APA was associated with the stimulation effect on FoG (trend; r = 0.580, P = 0.102). The APA modulation was not correlated with any other cognitive or clinical measures.CONCLUSION: Neuromodulation of the SNr but not of the STN modulated APAs in PD patients with FoG. The different effects of STN or SNr on the kinematic parameters of APA support the concept of segregate targets in order to address diverse kinematic components of PD gait.

U2 - 10.1016/j.parkreldis.2019.06.023

DO - 10.1016/j.parkreldis.2019.06.023

M3 - SCORING: Journal article

C2 - 31272926

VL - 66

SP - 34

EP - 39

JO - PARKINSONISM RELAT D

JF - PARKINSONISM RELAT D

SN - 1353-8020

ER -